Featured Publications
Angiophagy Prevents Early Embolus Washout But Recanalizes Microvessels Through Embolus Extravasation
Grutzendler J, Murikinati S, Hiner B, Ji L, Lam CK, Yoo T, Gupta S, Hafler BP, Adelman RA, Yuan P, Rodriguez G. Angiophagy Prevents Early Embolus Washout But Recanalizes Microvessels Through Embolus Extravasation. Science Translational Medicine 2014, 6: 226ra31. PMID: 24598589, DOI: 10.1126/scitranslmed.3006585.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainCerebrovascular CirculationCoronary CirculationEmbolismFibrinFibrinolysisFundus OculiGreen Fluorescent ProteinsHemodynamicsHumansKidney TubulesLungMacrophagesMiceMice, TransgenicMicrocirculationMicrogliaMicroscopy, Electron, TransmissionMicrovesselsMonocytesPhagocytosisRetinaRetinal VesselsThrombosisConceptsBlood flow reestablishmentHours of occlusionVascular occlusive disordersDifferent therapeutic strategiesEmbolic occlusionOcclusive disordersVessel recanalizationAlveolar spaceTherapeutic strategiesTherapeutic targetHemodynamic pressureFibrinolytic systemPerivascular spacesEmboliRenal tubulesBlood clotsMicrovascular wallMost human organsOcclusionLungExtravasationKidneyEndotheliumMicrovasculatureWashout
2016
“Small Blood Vessels: Big Health Problems?”: Scientific Recommendations of the National Institutes of Health Workshop
Bosetti F, Galis Z, Bynoe M, Charette M, Cipolla M, del Zoppo G, Gould D, Hatsukami T, Jones T, Koenig J, Lutty G, Maric‐Bilkan C, Stevens T, Tolunay H, Koroshetz W, Participants T, Agalliu D, Antonetti D, Boehm M, Brooks C, Caron K, Chilian W, Daemen M, D'Amato R, Davis T, Ergul A, Faber J, Gomez A, Grayson P, Grumbach I, Grutzendler J, Gu C, Gutterman D, Hallenbeck J, Herman I, Humphrey J, Iadecola C, Inscho E, Kleinfeld D, Lo E, Lopez J, Macknik S, Malik A, Mayadas T, McGavern D, Meininger G, Miller V, Nedergaard M, Nelson M, Peirce‐Cottler S, Ramadan I, Rosenberg G, Schiffrin E, Searson P, Stachenfeld N, Stan R, Suarez Y, Ubogu E, Vexler Z, Weyand C, Zlokovic B. “Small Blood Vessels: Big Health Problems?”: Scientific Recommendations of the National Institutes of Health Workshop. Journal Of The American Heart Association 2016, 5: e004389. PMID: 27815267, PMCID: PMC5210346, DOI: 10.1161/jaha.116.004389.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2013
Perturbed neural activity disrupts cerebral angiogenesis during a postnatal critical period
Whiteus C, Freitas C, Grutzendler J. Perturbed neural activity disrupts cerebral angiogenesis during a postnatal critical period. Nature 2013, 505: 407-411. PMID: 24305053, PMCID: PMC3947100, DOI: 10.1038/nature12821.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornBlood VesselsCapillariesCell ProliferationCerebral CortexCerebrovascular CirculationDendritic SpinesEndothelial CellsFemaleHypoxia, BrainInterneuronsMaleMiceMicrocirculationNeovascularization, PathologicNeovascularization, PhysiologicNeurogliaNeuronsNG-Nitroarginine Methyl EsterNitric OxideNitric Oxide SynthaseOxygenSignal TransductionTime FactorsVibrissae