2004
Fibrillar amyloid deposition leads to local synaptic abnormalities and breakage of neuronal branches
Tsai J, Grutzendler J, Duff K, Gan WB. Fibrillar amyloid deposition leads to local synaptic abnormalities and breakage of neuronal branches. Nature Neuroscience 2004, 7: 1181-1183. PMID: 15475950, DOI: 10.1038/nn1335.Peer-Reviewed Original ResearchConceptsFibrillar amyloid depositionAmyloid depositionAlzheimer's diseaseTransgenic mouse modelImportance of preventionFibrillar amyloid depositsSpine lossNearby axonsNeuronal labelingEarly clearanceLarge varicositiesAmyloid plaquesMouse modelNeuronal circuitryAmyloid depositsTwo-photon imagingNeuronal connectionsSynaptic abnormalitiesNeuronal branchesPermanent disruptionPlaquesDiseaseAtrophyVaricositiesPathogenesis
2001
Two modes of radial migration in early development of the cerebral cortex
Nadarajah B, Brunstrom J, Grutzendler J, Wong R, Pearlman A. Two modes of radial migration in early development of the cerebral cortex. Nature Neuroscience 2001, 4: 143-150. PMID: 11175874, DOI: 10.1038/83967.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell MovementCellular SenescenceCerebral CortexEmbryo, MammalianEmbryonic and Fetal DevelopmentIn Vitro TechniquesMiceNeurogliaNeuronsConceptsCerebral cortexAcute cortical slicesCertain genetic mutationsFinal laminar positionSite of originMovement of neuronsCortical slicesCortical neuronsRadial migrationCortical developmentLaminar positionSomal translocationGenetic mutationsCell-type specificDifferential effectsEarly ageCortexNeuronsMarginal zoneLeading processCellsTranslocationEarly developmentTime-lapse imaging