2024
Neuroinflammation in Alzheimer disease
Heneka M, van der Flier W, Jessen F, Hoozemanns J, Thal D, Boche D, Brosseron F, Teunissen C, Zetterberg H, Jacobs A, Edison P, Ramirez A, Cruchaga C, Lambert J, Laza A, Sanchez-Mut J, Fischer A, Castro-Gomez S, Stein T, Kleineidam L, Wagner M, Neher J, Cunningham C, Singhrao S, Prinz M, Glass C, Schlachetzki J, Butovsky O, Kleemann K, De Jaeger P, Scheiblich H, Brown G, Landreth G, Moutinho M, Grutzendler J, Gomez-Nicola D, McManus R, Andreasson K, Ising C, Karabag D, Baker D, Liddelow S, Verkhratsky A, Tansey M, Monsonego A, Aigner L, Dorothée G, Nave K, Simons M, Constantin G, Rosenzweig N, Pascual A, Petzold G, Kipnis J, Venegas C, Colonna M, Walter J, Tenner A, O’Banion M, Steinert J, Feinstein D, Sastre M, Bhaskar K, Hong S, Schafer D, Golde T, Ransohoff R, Morgan D, Breitner J, Mancuso R, Riechers S. Neuroinflammation in Alzheimer disease. Nature Reviews Immunology 2024, 1-32. PMID: 39653749, DOI: 10.1038/s41577-024-01104-7.Peer-Reviewed Original ResearchAlzheimer's diseasePathogenesis of Alzheimer's diseaseMultiple lines of informationGenetic studiesInfluence of geneticsLines of informationCell typesDisease developmentDementia-causing diseasesStages of Alzheimer's diseasePathological roleMultiple linesTherapeutic strategiesImmune processesPreclinical stage of Alzheimer's diseaseCellsAdaptive immune activationTargeting neuroinflammationPathological mechanismsLifestyle factorsGenetics
2022
Oligodendroglial macroautophagy is essential for myelin sheath turnover to prevent neurodegeneration and death
Aber ER, Griffey CJ, Davies T, Li AM, Yang YJ, Croce KR, Goldman JE, Grutzendler J, Canman JC, Yamamoto A. Oligodendroglial macroautophagy is essential for myelin sheath turnover to prevent neurodegeneration and death. Cell Reports 2022, 41: 111480. PMID: 36261002, PMCID: PMC9639605, DOI: 10.1016/j.celrep.2022.111480.Peer-Reviewed Original ResearchConceptsCell typesLive-cell imagingNeurodegenerative disease pathophysiologySuch cell typesMouse geneticsAdult-onset neurodegenerative diseaseMacroautophagyCell imagingNeurodegenerative diseasesMyelin proteinsNeurodegenerationDisease pathophysiologyTurnoverMature oligodendrocytesCentral nervous systemAmphisomesMyelin sheath structureNeural functionNervous systemMyelin turnoverGeneticsMyelin sheathProgressive motor declineProteinHomeostasis