2024
Specific retinal neurons regulate context-dependent defensive responses to visual threat
Lee T, Weinberg-Wolf H, Zapadka T, Rudenko A, Demb J, Kim I. Specific retinal neurons regulate context-dependent defensive responses to visual threat. PNAS Nexus 2024, 3: pgae423. PMID: 39359403, PMCID: PMC11443969, DOI: 10.1093/pnasnexus/pgae423.Peer-Reviewed Original ResearchRetinal ganglion cellsBehavioral responsesRetinal ganglion cell typesVisual threatAlpha retinal ganglion cellsLooming stimuliThreatening stimuliMature miceGanglion cellsBehavioral reactionsUnique contributionsCell ablationVisual pathwayOutput neuronsEarly visual pathwayStimuliContextual signalsDefense responsesAerial predatorsEnvironmental contextSupermultipotency and unpredictability in the developing superior colliculus
Rudenko A, Kim I. Supermultipotency and unpredictability in the developing superior colliculus. Trends In Neurosciences 2024, 47: 239-240. PMID: 38514350, PMCID: PMC11047761, DOI: 10.1016/j.tins.2024.03.001.Peer-Reviewed Original Research
2023
Brn3b regulates the formation of fear-related midbrain circuits and defensive responses to visual threat
Lee H, Weinberg-Wolf H, Lee H, Lee T, Conte J, Godoy-Parejo C, Demb J, Rudenko A, Kim IJ. Brn3b regulates the formation of fear-related midbrain circuits and defensive responses to visual threat. PLOS Biology 2023, 21: e3002386. PMID: 37983249, PMCID: PMC10695396, DOI: 10.1371/journal.pbio.3002386.Peer-Reviewed Original ResearchConceptsTranscription factor Brn3bLoss of neuronsVisual threatLateral posterior nucleusMutant mice displayDefensive responsesDefensive freezing responsesPosterior nucleusTachykinin 2Mice displayMidbrain circuitVisual circuitsNeural circuitryBrn3bSpecific genetic componentsFreezing responseFear-associated behaviorsSocial isolationTac2Behavioral phenotypesMolecular mechanismsFunctional organizationGenetic componentResponseSimilar mechanism
2021
Optic nerve regeneration screen identifies multiple genes restricting adult neural repair
Lindborg JA, Tran NM, Chenette DM, DeLuca K, Foli Y, Kannan R, Sekine Y, Wang X, Wollan M, Kim IJ, Sanes JR, Strittmatter SM. Optic nerve regeneration screen identifies multiple genes restricting adult neural repair. Cell Reports 2021, 34: 108777. PMID: 33657370, PMCID: PMC8009559, DOI: 10.1016/j.celrep.2021.108777.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAxonsCRISPR-Cas SystemsDependovirusFemaleGene EditingGene Expression RegulationGenetic Association StudiesHEK293 CellsHumansInterleukinsMaleMAP Kinase Kinase KinasesMice, Inbred C57BLMice, TransgenicNerve RegenerationNeurogenesisOptic NerveOptic Nerve InjuriesRetinal Ganglion CellsSignal TransductionSTAT3 Transcription FactorConceptsOptic nerve crushRetinal ganglion cellsRegeneration-associated genesShort hairpin RNAIL-22Neural repairCentral nervous system traumaNeurological deficits persistNervous system traumaNerve crushAxonal damageAxonal regenerationGanglion cellsSystem traumaInflammatory responseCNS regenerationDeficits persistAxonal growthHairpin RNAConcurrent activationTranscription 3Cell-autonomous factorsKinase pathwaySignal transducerRepair
2020
Connectomic analysis reveals an interneuron with an integral role in the retinal circuit for night vision
Park SJ, Lieberman EE, Ke JB, Rho N, Ghorbani P, Rahmani P, Jun NY, Lee HL, Kim IJ, Briggman KL, Demb JB, Singer JH. Connectomic analysis reveals an interneuron with an integral role in the retinal circuit for night vision. ELife 2020, 9: e56077. PMID: 32412412, PMCID: PMC7228767, DOI: 10.7554/elife.56077.Peer-Reviewed Original ResearchConceptsAII amacrine cellsProjection neuronsSingle interneuron typeConnectomic analysisBipolar cell pathwaysNovel neural circuitGABAergic cellsAmacrine cellsCentral neuronsGanglion cellsSynaptic layersRetinal circuitsInterneuron typesSurround inhibitionMouse retinaNight visionON responseExcitatory centerOptogenetic analysesNeural circuitsInhibitory surroundCell pathwaysRod photoreceptorsReceptive fieldsRb pathway
2019
Rorβ regulates selective axon-target innervation in the mammalian midbrain
Byun H, Lee HL, Liu H, Forrest D, Rudenko A, Kim IJ. Rorβ regulates selective axon-target innervation in the mammalian midbrain. Development 2019, 146: dev171926. PMID: 31332038, PMCID: PMC6679361, DOI: 10.1242/dev.171926.Peer-Reviewed Original ResearchConceptsDorsal lateral geniculate nucleusLateral posterior nucleusLong-range neuronal connectionsSuperior colliculusNeuronal connectionsMammalian midbrainLateral geniculate nucleusThalamic nucleiAxonal projectionsGeniculate nucleusMidbrain centerPosterior nucleusMammalian brainInnervationRORβMidbrainDevelopmental mediatorTranscription factorsColliculusOpposite phenotypeNeuronsBrain
2018
Convergence and Divergence of CRH Amacrine Cells in Mouse Retinal Circuitry
Park SJH, Pottackal J, Ke JB, Jun NY, Rahmani P, Kim IJ, Singer JH, Demb JB. Convergence and Divergence of CRH Amacrine Cells in Mouse Retinal Circuitry. Journal Of Neuroscience 2018, 38: 3753-3766. PMID: 29572434, PMCID: PMC5895998, DOI: 10.1523/jneurosci.2518-17.2018.Peer-Reviewed Original ResearchConceptsAlpha ganglion cellsGanglion cell typesAmacrine cellsGanglion cellsCRH cellsAlpha cellsGABAergic synapsesInhibitory interneuronsExcitation/inhibition balanceCorticotropin-releasing hormoneCre transgenic miceFire action potentialsTonic excitatory driveCell typesBalance of excitationGABA releaseExcitatory circuitsRetinal circuitryExcitatory driveInhibition balanceInhibitory inputsMammalian retinaMouse retinaAction potentialsOptogenetic analyses
2017
Identification of Intrinsic Axon Growth Modulators for Intact CNS Neurons after Injury
Fink KL, López-Giráldez F, Kim IJ, Strittmatter SM, Cafferty WB. Identification of Intrinsic Axon Growth Modulators for Intact CNS Neurons after Injury. Cell Reports 2017, 18: 2687-2701. PMID: 28297672, PMCID: PMC5389739, DOI: 10.1016/j.celrep.2017.02.058.Peer-Reviewed Original ResearchConceptsSpinal cord injuryCentral nervous systemFunctional recoveryIntact neuronsAdult mammalian central nervous systemPartial spinal cord injuryInjury-induced sproutingUnilateral brainstem lesionsGreater functional recoverySpontaneous functional recoveryCorticospinal motor neuronsCorticospinal tract axonsMammalian central nervous systemWild-type miceNew synapse formationGrowth modulatorsAdjacent injuryBrainstem lesionsCord injuryFunctional deficitsIntact circuitryCNS neuronsMotor neuronsCircuit plasticityNervous system
2016
Molecular features distinguish ten neuronal types in the mouse superficial superior colliculus
Byun H, Kwon S, Ahn HJ, Liu H, Forrest D, Demb JB, Kim IJ. Molecular features distinguish ten neuronal types in the mouse superficial superior colliculus. The Journal Of Comparative Neurology 2016, 524: 2300-2321. PMID: 26713509, PMCID: PMC4892959, DOI: 10.1002/cne.23952.Peer-Reviewed Original ResearchConceptsSpecific cell typesCell typesMolecular markersEts variant gene 1Distinct expression patternsSuperior colliculusMouse SSCsTranscription factorsCadherin-7Retinoid-related orphan receptor βContactin-3Cell adhesion moleculeProtein 3BNeuronal typesSSC neuronsExpression patternsGene expressionMolecular mechanismsProtocadherin 20Gene 1Binding proteinCadherin-6Netrin-G2Calcium binding proteinMolecular families
2015
Function and Circuitry of VIP+ Interneurons in the Mouse Retina
Park SJ, Borghuis BG, Rahmani P, Zeng Q, Kim IJ, Demb JB. Function and Circuitry of VIP+ Interneurons in the Mouse Retina. Journal Of Neuroscience 2015, 35: 10685-10700. PMID: 26224854, PMCID: PMC4518048, DOI: 10.1523/jneurosci.0222-15.2015.Peer-Reviewed Original ResearchConceptsGanglion cell layerAmacrine cell typesInner nuclear layerAmacrine cellsGanglion cellsINL cellsON pathwayGanglion cell dendritesGanglion cell typesBipolar cell terminalsWhole-cell recordingsCell typesNervous system functionSpatial tuningBipolar cell pathwaysTransgenic mouse lineGCL cellsOptic nerveGABAergic interneuronsRetinal functionCell dendritesRetinal circuitryInhibitory interneuronsNuclear layerBipolar interneuronsSubtype-Specific Regeneration of Retinal Ganglion Cells following Axotomy: Effects of Osteopontin and mTOR Signaling
Duan X, Qiao M, Bei F, Kim IJ, He Z, Sanes JR. Subtype-Specific Regeneration of Retinal Ganglion Cells following Axotomy: Effects of Osteopontin and mTOR Signaling. Neuron 2015, 85: 1244-1256. PMID: 25754821, PMCID: PMC4391013, DOI: 10.1016/j.neuron.2015.02.017.Peer-Reviewed Original ResearchConceptsRetinal ganglion cellsDownregulation of PTENGanglion cellsInsulin-like growth factor-1Mouse retinal ganglion cellsAdministration of osteopontinAbility of RGCsSubtype-specific differencesGrowth factor-1Effect of osteopontinAxonal regenerationIGF-1High mTORSurvival rateΑRGCsMTOR pathwayPromising agentAxotomyMTOR signalingDistinct subsetsFactor 1Existence of subpopulationsInjuryOsteopontinDownregulation
2012
The most numerous ganglion cell type of the mouse retina is a selective feature detector
Zhang Y, Kim IJ, Sanes JR, Meister M. The most numerous ganglion cell type of the mouse retina is a selective feature detector. Proceedings Of The National Academy Of Sciences Of The United States Of America 2012, 109: e2391-e2398. PMID: 22891316, PMCID: PMC3437843, DOI: 10.1073/pnas.1211547109.Peer-Reviewed Original ResearchConceptsGanglion cellsBipolar cellsMouse retinaW3 cellsGanglion cell typesRetinal ganglion cellsStrong lateral inhibitionReceptive field sizeDifferent visual inputsHuman retinaRetinaNeural imagesCell poolCommon visual stimuliReceptive fieldsVisual stimuliVisual inputCell typesUnusual conditionVisual sceneResponse propertiesCellsLateral inhibitionDistinct populationsNaturalistic stimuli
2010
Laminar Restriction of Retinal Ganglion Cell Dendrites and Axons: Subtype-Specific Developmental Patterns Revealed with Transgenic Markers
Kim IJ, Zhang Y, Meister M, Sanes JR. Laminar Restriction of Retinal Ganglion Cell Dendrites and Axons: Subtype-Specific Developmental Patterns Revealed with Transgenic Markers. Journal Of Neuroscience 2010, 30: 1452-1462. PMID: 20107072, PMCID: PMC2822471, DOI: 10.1523/jneurosci.4779-09.2010.Peer-Reviewed Original ResearchConceptsRetinal ganglion cellsEarly postnatal stagesRGC subsetsSuperior colliculusSubset of RGCsRetinal ganglion cell dendritesPostnatal stagesGanglion cell dendritesInner plexiform layerLateral geniculate nucleusDevelopment of RGCsSpecific sublaminaeDistinct functional signaturesSubpial zoneGanglion cellsPlexiform layerCell dendritesAxonal projectionsDendritic arborsGeniculate nucleusSubtype-specific featuresAxonal arborsRetinorecipient layersMouse transgenic linesDiffuse pattern
2008
Molecular identification of a retinal cell type that responds to upward motion
Kim IJ, Zhang Y, Yamagata M, Meister M, Sanes JR. Molecular identification of a retinal cell type that responds to upward motion. Nature 2008, 452: 478-482. PMID: 18368118, DOI: 10.1038/nature06739.Peer-Reviewed Original Research