Bcl-xL induces Drp1-dependent synapse formation in cultured hippocampal neurons
Li H, Chen Y, Jones AF, Sanger RH, Collis LP, Flannery R, McNay EC, Yu T, Schwarzenbacher R, Bossy B, Bossy-Wetzel E, Bennett MV, Pypaert M, Hickman JA, Smith PJ, Hardwick JM, Jonas EA. Bcl-xL induces Drp1-dependent synapse formation in cultured hippocampal neurons. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 2169-2174. PMID: 18250306, PMCID: PMC2542873, DOI: 10.1073/pnas.0711647105.Peer-Reviewed Original ResearchConceptsBcl-xL proteinBcl-xLVesicle clustersDynamin-related protein 1Synapse formationOverexpression of Drp1Mitochondrial fission proteinSynaptic vesicle clustersMitochondrial localizationFission proteinsGTPase activityDrp1Cultured hippocampal neuronsMitochondrial functionHippocampal neuronsNeuronal synapsesRecombinant systemsABT-737Protein 1ProteinTissue lysatesAdult neuronsSpontaneous miniature synaptic currentsOverexpressionMiniature synaptic currents