Expression of the Voltage-Gated Sodium Channel NaV1.5 in the Macrophage Late Endosome Regulates Endosomal Acidification
Carrithers MD, Dib-Hajj S, Carrithers LM, Tokmoulina G, Pypaert M, Jonas EA, Waxman SG. Expression of the Voltage-Gated Sodium Channel NaV1.5 in the Macrophage Late Endosome Regulates Endosomal Acidification. The Journal Of Immunology 2007, 178: 7822-7832. PMID: 17548620, DOI: 10.4049/jimmunol.178.12.7822.Peer-Reviewed Original ResearchConceptsVoltage-gated sodium channelsEndosomal acidificationLate endosomesPlasma membraneDistinct subcellular localizationPrimary human monocyte-derived macrophagesSodium channelsHuman monocyte-derived macrophagesSubcellular localizationSodium channel Nav1.5Human monocytic cell lineMonocyte-derived macrophagesMonocytic cell lineCardiac voltage-gated sodium channelNovel mechanismCell linesEndosomesMembrane potentialChannel Nav1.5Endosomal pHTHP-1Neuronal channelsMacrophage functionMembraneAcidification