The Mitochondrial Complex V–Associated Large-Conductance Inner Membrane Current Is Regulated by Cyclosporine and Dexpramipexole
Alavian KN, Dworetzky SI, Bonanni L, Zhang P, Sacchetti S, Li H, Signore AP, Smith PJ, Gribkoff VK, Jonas EA. The Mitochondrial Complex V–Associated Large-Conductance Inner Membrane Current Is Regulated by Cyclosporine and Dexpramipexole. Molecular Pharmacology 2014, 87: 1-8. PMID: 25332381, PMCID: PMC4279080, DOI: 10.1124/mol.114.095661.Peer-Reviewed Original ResearchConceptsF1Fo-ATP synthaseInner mitochondrial membraneATP synthaseMitochondrial permeability transition poreSubmitochondrial vesiclesOligomycin sensitivity-conferring protein subunitMitochondrial membraneMitochondrial F1Fo-ATP synthaseMitochondrial matrix calciumFunctional conformational changesCellular energy productionHydrolysis of ATPPermeability transition poreC subunitIon conductanceATP/ADPProtein subunitsEnzyme complexOxidative phosphorylationConformational changesTransition poreComplex VLeak conductanceMatrix calciumEnergy production