2022
Emerging principles of spacetime in brains: Meeting report on spatial neurodynamics
Grün S, Li J, McNaughton B, Petersen C, McCormick D, Robson D, Buzsáki G, Harris K, Sejnowski T, Mrsic-Flogel T, Lindén H, Roland P. Emerging principles of spacetime in brains: Meeting report on spatial neurodynamics. Neuron 2022, 110: 1894-1898. PMID: 35709696, DOI: 10.1016/j.neuron.2022.05.018.Peer-Reviewed Original Research
2015
Competing Neural Ensembles in Motor Cortex Gate Goal-Directed Motor Output
Zagha E, Ge X, McCormick DA. Competing Neural Ensembles in Motor Cortex Gate Goal-Directed Motor Output. Neuron 2015, 88: 565-577. PMID: 26593093, PMCID: PMC4660255, DOI: 10.1016/j.neuron.2015.09.044.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsGoalsMaleMiceMice, Inbred C57BLMice, TransgenicMotor CortexMovementNerve NetPsychomotor PerformanceConceptsPopulations of neuronsAnticipation of movementMotor cortexCortical neuronsCortical circuitsIntracellular techniquesUnit recordingsNeural ensemblesMotor outputNeuronsSensory stimuliNeural activityMotor representationsSensory detection taskMotor commandsFuture studiesTask-related neural dynamicsCortexMiceCellular activitiesWaking State: Rapid Variations Modulate Neural and Behavioral Responses
McGinley MJ, Vinck M, Reimer J, Batista-Brito R, Zagha E, Cadwell CR, Tolias AS, Cardin JA, McCormick DA. Waking State: Rapid Variations Modulate Neural and Behavioral Responses. Neuron 2015, 87: 1143-1161. PMID: 26402600, PMCID: PMC4718218, DOI: 10.1016/j.neuron.2015.09.012.Peer-Reviewed Original Research
2013
Motor Cortex Feedback Influences Sensory Processing by Modulating Network State
Zagha E, Casale AE, Sachdev RN, McGinley MJ, McCormick DA. Motor Cortex Feedback Influences Sensory Processing by Modulating Network State. Neuron 2013, 79: 567-578. PMID: 23850595, PMCID: PMC3742632, DOI: 10.1016/j.neuron.2013.06.008.Peer-Reviewed Original Research
2012
Warm Body Temperature Facilitates Energy Efficient Cortical Action Potentials
Yu Y, Hill A, McCormick D. Warm Body Temperature Facilitates Energy Efficient Cortical Action Potentials. PLOS Computational Biology 2012, 8: e1002456. PMID: 22511855, PMCID: PMC3325181, DOI: 10.1371/journal.pcbi.1002456.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsBody TemperatureBrainComputer SimulationEnergy TransferHumansModels, NeurologicalNeuronsConceptsAction potentialsFiring rateBody temperatureFunctional brain imaging signalsAction potential durationSingle action potentialCortical action potentialsAction potential generationNormal body temperatureSpike firing rateAverage firing rateSpike afterhyperpolarizationEfficient neural codesPotential durationBrain imaging signalsMarked reductionChannel inactivationPotential generationNeural signal transmissionBrain architectureWarmer body temperaturesImaging signalsNeural codeDurationAfterhyperpolarization
2011
Active Action Potential Propagation But Not Initiation in Thalamic Interneuron Dendrites
Casale A, McCormick D. Active Action Potential Propagation But Not Initiation in Thalamic Interneuron Dendrites. Journal Of Neuroscience 2011, 31: 18289-18302. PMID: 22171033, PMCID: PMC3269759, DOI: 10.1523/jneurosci.4417-11.2011.Peer-Reviewed Original ResearchConceptsDorsal lateral geniculate nucleusLateral geniculate nucleusSomatic current injectionAction potentialsDendritic arborsGeniculate nucleusSynaptic stimulationThalamic interneuronsMouse dorsal lateral geniculate nucleusDendritic neurotransmitter releaseEntire dendritic arborSingle action potentialAxon initial segmentVoltage-gated sodiumProximal dendritesDendritic appendagesInhibitory neurotransmitterExcitatory inputsInhibitory interneuronsVoltage-sensitive dyeSynaptic inputsThalamocortical cellsCalcium transientsCalcium imagingNeurotransmitter release
2010
P/Q and N Channels Control Baseline and Spike-Triggered Calcium Levels in Neocortical Axons and Synaptic Boutons
Yu Y, Maureira C, Liu X, McCormick D. P/Q and N Channels Control Baseline and Spike-Triggered Calcium Levels in Neocortical Axons and Synaptic Boutons. Journal Of Neuroscience 2010, 30: 11858-11869. PMID: 20810905, PMCID: PMC2947942, DOI: 10.1523/jneurosci.2651-10.2010.Peer-Reviewed Original ResearchConceptsAxon initial segmentNeuronal excitabilityPyramidal cellsCalcium concentrationPresynaptic terminalsWhole-cell patch-clamp recordingsPrefrontal cortical pyramidal cellsOmega-agatoxin IVAOmega-conotoxin GVIACortical pyramidal cellsPatch-clamp recordingsBaseline calcium concentrationAction potential repolarizationAction potential generationNeocortical axonsVoltage-activated ion channelsCalcium currentCortical axonsSynaptic terminalsCalcium levelsCalcium channelsSynaptic boutonsSuprathreshold depolarizationElectrophysiological propertiesSubthreshold depolarization
2009
Spatial and Temporal Features of Synaptic to Discharge Receptive Field Transformation in Cat Area 17
Nowak L, Sanchez-Vives M, McCormick D. Spatial and Temporal Features of Synaptic to Discharge Receptive Field Transformation in Cat Area 17. Journal Of Neurophysiology 2009, 103: 677-697. PMID: 19906874, PMCID: PMC2822677, DOI: 10.1152/jn.90946.2008.Peer-Reviewed Original Research
2008
Cortical Action Potential Backpropagation Explains Spike Threshold Variability and Rapid-Onset Kinetics
Yu Y, Shu Y, McCormick DA. Cortical Action Potential Backpropagation Explains Spike Threshold Variability and Rapid-Onset Kinetics. Journal Of Neuroscience 2008, 28: 7260-7272. PMID: 18632930, PMCID: PMC2664555, DOI: 10.1523/jneurosci.1613-08.2008.Peer-Reviewed Original ResearchConceptsAxon initial segmentAction potentialsAction potential backpropagationAction potential outputAction potential responsesThreshold variabilityInitial segmentCortical neuronsSynaptic activitySynaptic inputsSomatic recordingsCortical ensemblesSensorimotor integrationRate variabilityAction potential eventsSpike initiationAmplitude-time courseTime courseHigh rateTrial variabilityNeurons
2007
State Changes Rapidly Modulate Cortical Neuronal Responsiveness
Hasenstaub A, Sachdev RN, McCormick DA. State Changes Rapidly Modulate Cortical Neuronal Responsiveness. Journal Of Neuroscience 2007, 27: 9607-9622. PMID: 17804621, PMCID: PMC6672966, DOI: 10.1523/jneurosci.2184-07.2007.Peer-Reviewed Original ResearchConceptsNeuronal responsivenessWhisker stimulationWhisker stimuliCircuit activityCortical neuronal responsivenessLocal circuit activityNetwork activityAction potential responsesLocal network activityRodent somatosensory cortexPostsynaptic potentialsSomatosensory cortexCortical neuronsIntracellular injectionWhisker deflectionCortical stateWhisker movementsPotential responsivenessAbility of stimuliSensory stimuliInhibitory mechanismStimulationResponsivenessSpontaneous alterationUp statesLack of Orientation and Direction Selectivity in a Subgroup of Fast-Spiking Inhibitory Interneurons: Cellular and Synaptic Mechanisms and Comparison with Other Electrophysiological Cell Types
Nowak L, Sanchez-Vives M, McCormick D. Lack of Orientation and Direction Selectivity in a Subgroup of Fast-Spiking Inhibitory Interneurons: Cellular and Synaptic Mechanisms and Comparison with Other Electrophysiological Cell Types. Cerebral Cortex 2007, 18: 1058-1078. PMID: 17720684, PMCID: PMC3136126, DOI: 10.1093/cercor/bhm137.Peer-Reviewed Original ResearchSelective control of cortical axonal spikes by a slowly inactivating K+ current
Shu Y, Yu Y, Yang J, McCormick D. Selective control of cortical axonal spikes by a slowly inactivating K+ current. Proceedings Of The National Academy Of Sciences Of The United States Of America 2007, 104: 11453-11458. PMID: 17581873, PMCID: PMC2040919, DOI: 10.1073/pnas.0702041104.Peer-Reviewed Original ResearchConceptsSpike durationLayer 5 pyramidal cellsWhole-cell recordingsIntracortical processingPyramidal cellsIntracortical axonsLow dosesDistal axonsAxonal spikesRepetitive dischargesAxonsMembrane potential changesRemarkable differential expressionSomaDifferential expressionAlpha subunitIonic channelsSmall increaseKv1.2 alpha subunitsDurationNeuronsDosesEnhancement of Visual Responsiveness by Spontaneous Local Network Activity In Vivo
Haider B, Duque A, Hasenstaub A, Yu Y, McCormick D. Enhancement of Visual Responsiveness by Spontaneous Local Network Activity In Vivo. Journal Of Neurophysiology 2007, 97: 4186-4202. PMID: 17409168, DOI: 10.1152/jn.01114.2006.Peer-Reviewed Original ResearchConceptsPostsynaptic potentialsVisual responsivenessSpontaneous depolarizationsNetwork activityNeocortical network activityInhibitory synaptic potentialsPrimary visual cortexLocal network activityAction potential generationContrast response functionsCortical neuronsSynaptic potentialsSynaptic transmissionSpontaneous activityMembrane potential depolarizationKetamine-xylazineExtracellular recordingsVisual cortexAction potentialsLocal circuitsIntegrative propertiesSensory responsesPotential depolarizationSlow oscillationsPotential generation
2006
Properties of Action-Potential Initiation in Neocortical Pyramidal Cells: Evidence From Whole Cell Axon Recordings
Shu Y, Duque A, Yu Y, Haider B, McCormick D. Properties of Action-Potential Initiation in Neocortical Pyramidal Cells: Evidence From Whole Cell Axon Recordings. Journal Of Neurophysiology 2006, 97: 746-760. PMID: 17093120, DOI: 10.1152/jn.00922.2006.Peer-Reviewed Original ResearchConceptsCortical pyramidal cellsAction potential initiationAxon initial segmentPyramidal cellsAction potentialsSynaptic activityLayer 5 pyramidal neuronsSimultaneous whole-cell recordingsWhole-cell recordingsNeocortical pyramidal cellsRecurrent network activityAction potential generationInitial segmentIntradendritic injectionPyramidal neuronsApical dendritesEpileptiform activityCortical neuronsEpileptiform dischargesIntracortical axonsEpileptic seizuresSynaptic bombardmentCell recordingsDistal axonsSynaptic barragesNeocortical Network Activity In Vivo Is Generated through a Dynamic Balance of Excitation and Inhibition
Haider B, Duque A, Hasenstaub A, McCormick D. Neocortical Network Activity In Vivo Is Generated through a Dynamic Balance of Excitation and Inhibition. Journal Of Neuroscience 2006, 26: 4535-4545. PMID: 16641233, PMCID: PMC6674060, DOI: 10.1523/jneurosci.5297-05.2006.Peer-Reviewed Original ResearchConceptsCerebral cortexNeocortical network activityReversal potentialUp statesPersistent network activityNetwork activityDepolarized reversal potentialSpontaneous network activityField potential recordingsLocal cortical circuitsLocal field potential recordingsNeuronal responsivenessCortical functionRecurrent excitatoryCortical circuitsSynaptic currentsPotential recordingsRecurrent excitationExcitatory conductancePrefrontal cortexInhibitory connectionsCortexStable network statesSlow oscillationsInhibitionModulation of intracortical synaptic potentials by presynaptic somatic membrane potential
Shu Y, Hasenstaub A, Duque A, Yu Y, McCormick D. Modulation of intracortical synaptic potentials by presynaptic somatic membrane potential. Nature 2006, 441: 761-765. PMID: 16625207, DOI: 10.1038/nature04720.Peer-Reviewed Original ResearchConceptsIntracortical synaptic potentialsSomatic membrane potentialCerebral cortexMembrane potentialPostsynaptic potentialsSynaptic potentialsSynaptic activityEpileptic seizuresAction potentialsSensory stimulationNeuronal communicationMembrane potential changesNeuronal signalsRecording pointsSole formPossible alternative mechanismSeizuresCortexAxonsNeurons
2005
Inhibitory Postsynaptic Potentials Carry Synchronized Frequency Information in Active Cortical Networks
Hasenstaub A, Shu Y, Haider B, Kraushaar U, Duque A, McCormick D. Inhibitory Postsynaptic Potentials Carry Synchronized Frequency Information in Active Cortical Networks. Neuron 2005, 47: 423-435. PMID: 16055065, DOI: 10.1016/j.neuron.2005.06.016.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsCerebral CortexCortical SynchronizationExcitatory Postsynaptic PotentialsFerretsIn Vitro TechniquesInterneuronsMaleMembrane PotentialsNerve NetNeural InhibitionNeuronsOscillometryPyramidal CellsReaction TimeRefractory Period, ElectrophysiologicalSynapsesSynaptic TransmissionConceptsInhibitory postsynaptic potentialsHigh-frequency activityPostsynaptic potentialsPyramidal cellsCortical pyramidal cellsAction potential propertiesRecurrent network activityAction potential generationActive cortical networkInhibitory interneuronsCortical functionIntracellular injectionNearby neuronsStrong barragesInhibitory networksCortical networksField potentialsSynaptic conductancesIPSPsInhibitory potentialPotential generationNetwork activitySpike timingMore synchronyVivoExcitatory Effects of Thyrotropin-Releasing Hormone in the Thalamus
Broberger C, McCormick D. Excitatory Effects of Thyrotropin-Releasing Hormone in the Thalamus. Journal Of Neuroscience 2005, 25: 1664-1673. PMID: 15716402, PMCID: PMC6725920, DOI: 10.1523/jneurosci.3198-04.2005.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsBicucullineCalcium SignalingEpilepsyFemaleFerretsGABA AntagonistsGamma-Aminobutyric AcidGeniculate BodiesIn Vitro TechniquesInterneuronsIon TransportMaleMethacholine ChlorideMuscarinic AgonistsPatch-Clamp TechniquesPotassiumPotassium ChannelsReceptors, GABA-AThalamusThyrotropin-Releasing HormoneWakefulnessConceptsThyrotropin-releasing hormoneThalamocortical cellsApplication of TRHNeuropeptide thyrotropin-releasing hormoneRapid eye movement (REM) sleepRhythmic burst firingAnti-epileptic effectsEye movement sleepApplication of bicucullineLateral geniculate nucleusSlow-wave sleepThalamocortical network activityAction potential generationSingle-spike modeNonspecific currentsPerigeniculate neuronsExcitatory effectsGABAergic neuronsMovement sleepPGN neuronsBath applicationBurst firingGeniculate nucleusIntracellular recordingsDirect depolarizationRole of Synaptic and Intrinsic Membrane Properties in Short-Term Receptive Field Dynamics in Cat Area 17
Nowak L, Sanchez-Vives M, McCormick D. Role of Synaptic and Intrinsic Membrane Properties in Short-Term Receptive Field Dynamics in Cat Area 17. Journal Of Neuroscience 2005, 25: 1866-1880. PMID: 15716423, PMCID: PMC6725929, DOI: 10.1523/jneurosci.3897-04.2005.Peer-Reviewed Original ResearchConceptsHigh-contrast stimulationMembrane potential hyperpolarizationPotential hyperpolarizationCat primary visual cortexRole of synapticIntrinsic membrane propertiesPrimary visual cortexCat area 17Significant reductionHigh-contrast stimuliGray screenArea 17Synaptic mechanismsLack of stimulationVisual cortexArtificial scotomaRF sizeReceptive field dynamicsSine-wave gratingsSingle neuronsStimulationStrong visual stimuliHigh-contrast sine-wave gratingsHyperpolarizationVisual stimuli
2004
Slow Adaptation in Fast-Spiking Neurons of Visual Cortex
Descalzo V, Nowak L, Brumberg J, McCormick D, Sanchez-Vives M. Slow Adaptation in Fast-Spiking Neurons of Visual Cortex. Journal Of Neurophysiology 2004, 93: 1111-1118. PMID: 15385594, DOI: 10.1152/jn.00658.2004.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAdaptation, PhysiologicalAnimalsCatsFemaleFerretsIn Vitro TechniquesMaleNeuronsTime FactorsVisual CortexConceptsFS neuronsSpike frequency adaptationSlower time courseShort-duration action potentialsTime courseNeuron's functional propertiesPostadaptation periodSlow afterhyperpolarizationCortical slicesNeuron dischargeAfferent inputInhibitory interneuronsVisual cortexAction potentialsNeuronsSlow adaptationPrevious studiesAfterhyperpolarizationInterneuronsExcitabilityCortexDischarge