2018
The temporal organization of mouse ultrasonic vocalizations
Castellucci G, Calbick D, McCormick D. The temporal organization of mouse ultrasonic vocalizations. PLOS ONE 2018, 13: e0199929. PMID: 30376572, PMCID: PMC6207298, DOI: 10.1371/journal.pone.0199929.Peer-Reviewed Original ResearchConceptsUltrasonic vocalizationsAdult male C57BL/6J miceMale C57BL/6J miceMouse ultrasonic vocalizationsUSV productionC57BL/6J miceMale miceMouse modelRespiratory patternCommon biological mechanismsMiceMale ultrasonic vocalizationsAdults reliesBiological mechanismsRhythmic seriesTemporal organizationVocalization productionAdult malesHuman diseasesSpectrotemporal featuresFirst reportArticulatory patternsMammalian species
2015
Waking State: Rapid Variations Modulate Neural and Behavioral Responses
McGinley MJ, Vinck M, Reimer J, Batista-Brito R, Zagha E, Cadwell CR, Tolias AS, Cardin JA, McCormick DA. Waking State: Rapid Variations Modulate Neural and Behavioral Responses. Neuron 2015, 87: 1143-1161. PMID: 26402600, PMCID: PMC4718218, DOI: 10.1016/j.neuron.2015.09.012.Peer-Reviewed Original Research
2007
State Changes Rapidly Modulate Cortical Neuronal Responsiveness
Hasenstaub A, Sachdev RN, McCormick DA. State Changes Rapidly Modulate Cortical Neuronal Responsiveness. Journal Of Neuroscience 2007, 27: 9607-9622. PMID: 17804621, PMCID: PMC6672966, DOI: 10.1523/jneurosci.2184-07.2007.Peer-Reviewed Original ResearchConceptsNeuronal responsivenessWhisker stimulationWhisker stimuliCircuit activityCortical neuronal responsivenessLocal circuit activityNetwork activityAction potential responsesLocal network activityRodent somatosensory cortexPostsynaptic potentialsSomatosensory cortexCortical neuronsIntracellular injectionWhisker deflectionCortical stateWhisker movementsPotential responsivenessAbility of stimuliSensory stimuliInhibitory mechanismStimulationResponsivenessSpontaneous alterationUp states
2004
Slow Adaptation in Fast-Spiking Neurons of Visual Cortex
Descalzo V, Nowak L, Brumberg J, McCormick D, Sanchez-Vives M. Slow Adaptation in Fast-Spiking Neurons of Visual Cortex. Journal Of Neurophysiology 2004, 93: 1111-1118. PMID: 15385594, DOI: 10.1152/jn.00658.2004.Peer-Reviewed Original ResearchConceptsFS neuronsSpike frequency adaptationSlower time courseShort-duration action potentialsTime courseNeuron's functional propertiesPostadaptation periodSlow afterhyperpolarizationCortical slicesNeuron dischargeAfferent inputInhibitory interneuronsVisual cortexAction potentialsNeuronsSlow adaptationPrevious studiesAfterhyperpolarizationInterneuronsExcitabilityCortexDischarge
2003
Adaptation and Temporal Decorrelation by Single Neurons in the Primary Visual Cortex
Wang X, Liu Y, Sanchez-Vives M, McCormick D. Adaptation and Temporal Decorrelation by Single Neurons in the Primary Visual Cortex. Journal Of Neurophysiology 2003, 89: 3279-3293. PMID: 12649312, DOI: 10.1152/jn.00242.2003.Peer-Reviewed Original ResearchConceptsPrimary visual cortical neuronsVisual cortical slicesCellular mechanismsVisual cortical neuronsIntrinsic membrane propertiesPrimary visual cortexPossible cellular mechanismsSensory inputSlow afterhyperpolarizationIntrinsic ionic currentsCortical slicesLayer 2/3Cortical neuronsNeocortical neuronsIntracellular injectionV1 neuronsNeuronal responsesVisual cortexEfficient neural codingModel neuronsReal-world sensory inputsNeuronsIonic currentsProlonged changesSingle neurons
1995
Synaptic and membrane mechanisms underlying synchronized oscillations in the ferret lateral geniculate nucleus in vitro.
Bal T, von Krosigk M, McCormick D. Synaptic and membrane mechanisms underlying synchronized oscillations in the ferret lateral geniculate nucleus in vitro. The Journal Of Physiology 1995, 483: 641-663. PMID: 7776249, PMCID: PMC1157808, DOI: 10.1113/jphysiol.1995.sp020612.Peer-Reviewed Original ResearchConceptsInhibitory postsynaptic potentialsLGNd relay cellsLateral geniculate nucleusPerigeniculate nucleusRelay cellsGABAB receptorsSpindle wavesPGN neuronsGeniculate nucleusBicuculline-sensitive inhibitory postsynaptic potentialsExcitatory amino acid transmissionDorsal lateral geniculate nucleusFerret dorsal lateral geniculate nucleusFerret lateral geniculate nucleusAmino acid transmissionReversal potentialIntracellular recording techniquesLow-threshold Ca2Vitro. 2Mean reversal potentialSingle-unit activityLocal electrical stimulationKCl-filled microelectrodesPharmacological antagonismBicuculline methiodide
1994
Enhanced activation of NMDA receptor responses at the immature retinogeniculate synapse
Ramoa A, McCormick D. Enhanced activation of NMDA receptor responses at the immature retinogeniculate synapse. Journal Of Neuroscience 1994, 14: 2098-2105. PMID: 7908957, PMCID: PMC6577156, DOI: 10.1523/jneurosci.14-04-02098.1994.Peer-Reviewed Original ResearchMeSH Keywords2-Amino-5-phosphonovalerate6-Cyano-7-nitroquinoxaline-2,3-dioneAfferent PathwaysAgingAnimalsBicucullineElectric StimulationEvoked PotentialsFerretsGeniculate BodiesIn Vitro TechniquesKineticsNeuronsQuinoxalinesReceptors, N-Methyl-D-AspartateRetinaSynapsesSynaptic TransmissionTime FactorsVisual PathwaysConceptsNMDA receptorsBicuculline methiodideNMDA-EPSCsPostnatal monthPostnatal weekGABAA receptor-mediated IPSPsAMPA/kainate receptorsOptic tract stimulationReceptor-mediated IPSPsExcitatory postsynaptic currentsNMDA receptor responsesFirst postnatal monthSecond postnatal weekVoltage-clamp recordingsDorsal LGNEPSC durationRetinogeniculate transmissionD-APVSlow EPSPTract stimulationExcitatory transmissionGABAergic inhibitionNeonatal ageRetinogeniculate synapsePostsynaptic currentsDevelopmental changes in electrophysiological properties of LGNd neurons during reorganization of retinogeniculate connections
Ramoa A, McCormick D. Developmental changes in electrophysiological properties of LGNd neurons during reorganization of retinogeniculate connections. Journal Of Neuroscience 1994, 14: 2089-2097. PMID: 8158259, PMCID: PMC6577110, DOI: 10.1523/jneurosci.14-04-02089.1994.Peer-Reviewed Original ResearchConceptsLGNd neuronsImmature neuronsAction potentialsElectrophysiological propertiesLittle spike frequency adaptationDependent action potentialsAction potential activityEarly postnatal lifeWhole-cell recordingsEarly postnatal developmentPatch-clamp techniqueSpike frequency adaptationHigh input resistanceDorsal LGNImmature synapsesCritical developmental periodRetinogeniculate connectionsMembrane potentialPostnatal weekIntracellular injectionPostnatal lifePostnatal developmentNeuronsInput resistanceFrequency adaptation
1993
A model for 8–10 Hz spindling in interconnected thalamic relay and reticularis neurons
Destexhe A, McCormick D, Sejnowski T. A model for 8–10 Hz spindling in interconnected thalamic relay and reticularis neurons. Biophysical Journal 1993, 65: 2473-2477. PMID: 8312485, PMCID: PMC1225988, DOI: 10.1016/s0006-3495(93)81297-9.Peer-Reviewed Original ResearchConceptsReticular cellsReticular thalamic cellsInhibitory postsynaptic potentialsIntrinsic oscillatory propertiesReticularis neuronsSpindle rhythmicityPostsynaptic potentialsInhibitory synapsesThalamic cellsThalamic relayThalamocortical cellsSilent periodSynaptic interactionsSpindle oscillationsRhythmic oscillationsCells
1992
Simulation of the currents involved in rhythmic oscillations in thalamic relay neurons
Huguenard J, McCormick D. Simulation of the currents involved in rhythmic oscillations in thalamic relay neurons. Journal Of Neurophysiology 1992, 68: 1373-1383. PMID: 1279135, DOI: 10.1152/jn.1992.68.4.1373.Peer-Reviewed Original Research
1986
Mechanisms of action of acetylcholine in the guinea‐pig cerebral cortex in vitro.
McCormick D, Prince D. Mechanisms of action of acetylcholine in the guinea‐pig cerebral cortex in vitro. The Journal Of Physiology 1986, 375: 169-194. PMID: 2879035, PMCID: PMC1182754, DOI: 10.1113/jphysiol.1986.sp016112.Peer-Reviewed Original ResearchConceptsNon-pyramidal cellsSlow excitatory responsesPyramidal neuronesMechanism of actionAction potentialsExcitatory responsesInhibitory responsesACh applicationGuinea pig cerebral cortexLayer V pyramidal cellsInhibitory post-synaptic potentialsGABAergic synaptic transmissionRelease of GABAShort-latency excitationSlow depolarizing responseApparent input resistanceACh-induced hyperpolarizationApplication of acetylcholineGamma-aminobutyric acidGuinea pig neocortexPost-synaptic potentialsAverage reversal potentialBarrages of excitatoryMinimum onset latencyAction potential generation