2008
Cortical Action Potential Backpropagation Explains Spike Threshold Variability and Rapid-Onset Kinetics
Yu Y, Shu Y, McCormick DA. Cortical Action Potential Backpropagation Explains Spike Threshold Variability and Rapid-Onset Kinetics. Journal Of Neuroscience 2008, 28: 7260-7272. PMID: 18632930, PMCID: PMC2664555, DOI: 10.1523/jneurosci.1613-08.2008.Peer-Reviewed Original ResearchConceptsAxon initial segmentAction potentialsAction potential backpropagationAction potential outputAction potential responsesThreshold variabilityInitial segmentCortical neuronsSynaptic activitySynaptic inputsSomatic recordingsCortical ensemblesSensorimotor integrationRate variabilityAction potential eventsSpike initiationAmplitude-time courseTime courseHigh rateTrial variabilityNeurons
2007
State Changes Rapidly Modulate Cortical Neuronal Responsiveness
Hasenstaub A, Sachdev RN, McCormick DA. State Changes Rapidly Modulate Cortical Neuronal Responsiveness. Journal Of Neuroscience 2007, 27: 9607-9622. PMID: 17804621, PMCID: PMC6672966, DOI: 10.1523/jneurosci.2184-07.2007.Peer-Reviewed Original ResearchConceptsNeuronal responsivenessWhisker stimulationWhisker stimuliCircuit activityCortical neuronal responsivenessLocal circuit activityNetwork activityAction potential responsesLocal network activityRodent somatosensory cortexPostsynaptic potentialsSomatosensory cortexCortical neuronsIntracellular injectionWhisker deflectionCortical stateWhisker movementsPotential responsivenessAbility of stimuliSensory stimuliInhibitory mechanismStimulationResponsivenessSpontaneous alterationUp states