2023
The active zone protein Clarinet regulates synaptic sorting of ATG-9 and presynaptic autophagy
Xuan Z, Yang S, Clark B, Hill S, Manning L, Colón-Ramos D. The active zone protein Clarinet regulates synaptic sorting of ATG-9 and presynaptic autophagy. PLOS Biology 2023, 21: e3002030. PMID: 37053235, PMCID: PMC10101500, DOI: 10.1371/journal.pbio.3002030.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAutophagyCaenorhabditis elegansNeuronsPresynaptic TerminalsProtein TransportSynapsesConceptsATG-9Presynaptic autophagyAdaptor protein complexesZone proteinActive zone proteinsC. elegans neuronsSynaptic vesicle proteinsGenetic screenPeriactive zoneAutophagosome biogenesisCellular homeostasisProtein complexesVesicle proteinsGenetic analysisLong isoformNovel roleSynaptic vesiclesAutophagyDistinct mechanismsProteinVesiclesSortingCLA-1Abnormal accumulationActive zone
2012
Synaptic vesicle clustering requires a distinct MIG-10/Lamellipodin isoform and ABI-1 downstream from Netrin
Stavoe AK, Nelson JC, Martínez-Velázquez LA, Klein M, Samuel AD, Colón-Ramos DA. Synaptic vesicle clustering requires a distinct MIG-10/Lamellipodin isoform and ABI-1 downstream from Netrin. Genes & Development 2012, 26: 2206-2221. PMID: 23028145, PMCID: PMC3465741, DOI: 10.1101/gad.193409.112.Peer-Reviewed Original ResearchConceptsN-terminal domainActin cytoskeletonUnique N-terminal domainNeurodevelopmental programsSpecific subcellular domainsDistinct subcellular compartmentsN-terminal motifSynaptic vesicle clusteringIndividual cellular responsesNetrin signalsThermotaxis behaviorSubcellular compartmentsVesicle clusteringSubcellular domainsCellular responsesSynaptic vesiclesNetrinProtein 1IsoformsPresynaptic regionCytoskeletonMotifPresynaptic sitesVesiclesNeurodevelopmental response