2024
Neural correlates of proactive avoidance deficits and alcohol use motives in problem drinking
Le T, Oba T, Couch L, McInerney L, Li C. Neural correlates of proactive avoidance deficits and alcohol use motives in problem drinking. Translational Psychiatry 2024, 14: 336. PMID: 39168986, PMCID: PMC11339324, DOI: 10.1038/s41398-024-03039-y.Peer-Reviewed Original ResearchConceptsAvoidance deficitNegative emotionsDrinking motivesAlcohol useNeural correlatesProblem drinkingRight anterior insula activityAssociated with greater alcohol useAnterior insula activityAlcohol use motivesGreater alcohol useProblem drinking groupInfluence alcohol usePhysical painInsula activationDrinking severityGo/NoGo taskNeural underpinningsPutamen responseSocial drinkersBehavioral measuresAvoidance performanceBehavioral resultsFunctional connectivityDrinking behaviorRelationship between plasma TNF-α levels and agitation symptoms in first episode patients with schizophrenia
Wang X, Chen W, Gou M, Li W, Li N, Tong J, Zhou Y, Xie T, Yu T, Feng W, Li Y, Chen S, Tian B, Tan S, Wang Z, Pan S, Luo X, Zhang P, Huang J, Tian L, Li C, Tan Y. Relationship between plasma TNF-α levels and agitation symptoms in first episode patients with schizophrenia. BMC Psychiatry 2024, 24: 480. PMID: 38956509, PMCID: PMC11218378, DOI: 10.1186/s12888-024-05796-y.Peer-Reviewed Original ResearchConceptsPositive and Negative Syndrome ScalePlasma TNF-a levelsAgitation symptomsPANSS-ECEpisode patientsTNF-a levelsPositive and Negative Syndrome Scale total scorePANSS-EC scoreNegative Syndrome ScaleSymptoms of schizophreniaPathophysiology of schizophreniaEnzyme-linked immunosorbent assayTNF-aR1 levelSyndrome ScalePlasma levels of tumor necrosis factor-alphaLevels of tumor necrosis factor-alphaSchizophreniaTotal scoreTumor necrosis factor-alphaNecrosis factor-alphaPlasma TNF-aHealthy controlsFEPImmune abnormalitiesLigand‐gated ion channels as potential biomarkers for ADT‐mediated cognitive decline in prostate cancer patients
Verma S, Singh V, Nagampalli V, Ponsky L, Li C, Chao H, Gupta S. Ligand‐gated ion channels as potential biomarkers for ADT‐mediated cognitive decline in prostate cancer patients. Molecular Carcinogenesis 2024, 63: 1051-1063. PMID: 38482990, PMCID: PMC11096008, DOI: 10.1002/mc.23708.Peer-Reviewed Original ResearchConceptsAndrogen deprivation therapyN-methyl-D-aspartate receptorsGamma-aminobutyric acidLigand-gated ion channelsType 1 angiotensin II receptorGlial cellsAndrogen signaling inhibitorsProstate cancer cell culture modelHigher risk of cognitive dysfunctionProstate cancer patientsPotential biomarkersBrain-derived neurotrophic factorCognitive dysfunctionIon channelsProtein-protein interaction network analysisAngiotensin II receptorsNuclear receptor subfamily 3 group C member 1Real-time polymerase chain reaction assayBrain glial cellsCytokine-cytokine receptor interactionCancer cell culture modelsAnalysis of genesGene-disease associationsInteraction network analysisPolymerase chain reaction assayNeurogenetic underpinnings of nicotine use severity: Integrating the brain transcriptomes and GWAS variants via network approaches
Yang B, Xiang B, Wang T, Ma S, Li C. Neurogenetic underpinnings of nicotine use severity: Integrating the brain transcriptomes and GWAS variants via network approaches. Psychiatry Research 2024, 334: 115815. PMID: 38422867, PMCID: PMC11017751, DOI: 10.1016/j.psychres.2024.115815.Peer-Reviewed Original ResearchConceptsMediodorsal nucleus of the thalamusMedial prefrontal cortexPrefrontal cortexNeurogenetic underpinningsDorsolateral prefrontal cortexBrain transcriptomeDrug memoryOrbitofrontal cortexInhibitory controlSmoking severityAssociated with CPDHuman brain transcriptomeMediodorsal nucleusWhole-brainNeurogenetic mechanismsPrimary motor cortexMechanisms of individual variationCortexHub proteinsGenetic riskAmygdalaStriatumMotor cortexOPFCHippocampusThe Neural Correlates of Individual Differences in Reinforcement Learning during Pain Avoidance and Reward Seeking
Le T, Oba T, Couch L, McInerney L, Li C. The Neural Correlates of Individual Differences in Reinforcement Learning during Pain Avoidance and Reward Seeking. ENeuro 2024, 11: eneuro.0437-23.2024. PMID: 38365840, PMCID: PMC10901196, DOI: 10.1523/eneuro.0437-23.2024.Peer-Reviewed Original ResearchConceptsSuperior frontal gyrusReward-seekingCingulate cortexNeural correlatesPain avoidanceAction biasDorsal anterior cingulate cortexLeft posterior cingulate cortexAction-outcome associationsGo/No-Go taskAnterior cingulate cortexPosterior cingulate cortexImpact of outcomesHigher learning rateReward trialsFrontal gyrusAvoidance learningMidcingulate cortexNeural substratesAssociative learningAction tendenciesPre-SMAAssociated with activationPrecentral gyrusPostcentral gyrusSex differences in the effects of individual anxiety state on regional responses to negative emotional scenes
Chaudhary S, Wong H, Chen Y, Zhang S, Li C. Sex differences in the effects of individual anxiety state on regional responses to negative emotional scenes. Biology Of Sex Differences 2024, 15: 15. PMID: 38351045, PMCID: PMC10863151, DOI: 10.1186/s13293-024-00591-6.Peer-Reviewed Original ResearchConceptsMedial prefrontal cortexState-Trait Anxiety InventoryFunctional magnetic resonance imagingState-Trait Anxiety Inventory scoresSuperior frontal gyrusGeneralized psychophysiological interactionEmotional processingFrontal gyrusLingual gyrusMedial prefrontal cortex connectivityMedial prefrontal cortex activationSex differencesRight inferior frontal gyrusResponse to negative emotionsRight superior frontal gyrusFunctional magnetic resonance imaging dataReaction timeImpact emotional processingNegative emotion processingInferior frontal gyrusLeft parahippocampal gyrusNegative emotional scenesMarkers of anxietyRepeated-measures analysis of covarianceLevels of anxiety
2023
Role of the immune-kynurenine pathway in treatment-resistant schizophrenia
Chen W, Tian Y, Gou M, Wang L, Tong J, Zhou Y, Feng W, Li Y, Chen S, Liu Y, Wang Z, Pan S, Zhang P, Huang J, Yang X, Li C, Tian L, Hong L, Tan Y. Role of the immune-kynurenine pathway in treatment-resistant schizophrenia. Progress In Neuro-Psychopharmacology And Biological Psychiatry 2023, 130: 110926. PMID: 38147973, DOI: 10.1016/j.pnpbp.2023.110926.Peer-Reviewed Original ResearchConceptsImmune-inflammatory response systemTreatment-resistant schizophreniaQUIN/KYNA ratioNon-TRS patientsHealthy controlsKynurenine pathwayKP metabolismKP activationKynurenic acidQuinolinic acidInflammation-related effectsPeripheral immune responseAnti-inflammatory cytokinesPro-inflammatory cytokinesBinary logistic regression analysisPathophysiology of schizophreniaLogistic regression analysisAge of onsetLower kynurenineKP metabolitesKYNA levelsIllness onsetPlasma levelsRisk factorsNMDA receptorsA 2-year mental health follow-up study subsequent to COVID-19
Hu K, Hu Y, Godfrey K, Li Q, Li C. A 2-year mental health follow-up study subsequent to COVID-19. Psychiatry Research 2023, 333: 115684. PMID: 38219344, DOI: 10.1016/j.psychres.2023.115684.Peer-Reviewed Original ResearchConceptsAcademic difficultiesCollege studentsMeasures of lonelinessPandemic onsetPandemic-induced stressMental health impactsPsychological symptomsSex differencesHeightened fearEmotional statesMental healthLearning difficultiesParticipants' fearLonelinessFearStudentsEducation of college studentsDifficultiesResilienceMid-2022HappinessOnsetSymptomsUnited StatesParticipantsSleep Deficits Inter-Link Lower Basal Forebrain–Posterior Cingulate Connectivity and Perceived Stress and Anxiety Bidirectionally in Young Men
Li G, Zhong D, Li B, Chen Y, Yang L, Li C. Sleep Deficits Inter-Link Lower Basal Forebrain–Posterior Cingulate Connectivity and Perceived Stress and Anxiety Bidirectionally in Young Men. The International Journal Of Neuropsychopharmacology 2023, 26: 879-889. PMID: 37924270, PMCID: PMC10726414, DOI: 10.1093/ijnp/pyad062.Peer-Reviewed Original ResearchThe effects of cocaine use severity and abstinence on behavioral performance and neural processes of response inhibition
Li G, Zhang Z, Zhang Y, Tang X, Li C. The effects of cocaine use severity and abstinence on behavioral performance and neural processes of response inhibition. Psychiatry Research Neuroimaging 2023, 336: 111734. PMID: 37871409, DOI: 10.1016/j.pscychresns.2023.111734.Peer-Reviewed Original ResearchConceptsDays of abstinenceStop-signal reaction timeHealthy controlsCocaine dependenceSuperior temporal gyrusCocaine use severityStop-signal taskCocaine useResponse inhibitionUse severityBilateral superior temporal gyrusFunctional magnetic resonanceWhole-brain regressionNeural processesPoor response inhibitionInhibition dysfunctionCerebral markersTemporal gyrusSTG activityAbstinenceSuccess trialsSeverityNeural mechanismsInhibitionBehavioral performanceRegional Homogeneity in schizophrenia patients with tardive dyskinesia: a resting-state fMRI study
Yu T, Li Y, Li N, Huang J, Fan F, Luo X, Tan S, Yang F, Tian B, Tian L, Li C, Tan Y. Regional Homogeneity in schizophrenia patients with tardive dyskinesia: a resting-state fMRI study. Psychiatry Research Neuroimaging 2023, 335: 111724. PMID: 37871408, DOI: 10.1016/j.pscychresns.2023.111724.Peer-Reviewed Original ResearchConceptsAbnormal Involuntary Movement ScaleTardive dyskinesiaInferior semilunar lobuleSchizophrenia patientsCourse of TDRegional homogeneityResting-state functional magnetic resonance imagingResting-state fMRI studySeverity of TDCerebral regional homogeneityUpper limb scoreNegative Syndrome ScaleNon-TD groupMedial frontal gyrusFunctional magnetic resonance imagingMagnetic resonance imagingLower ReHoReHo valuesHigher ReHoLimb scoreNeuronal degenerationHealthy controlsFunctional abnormalitiesMovement ScaleLeft supramarginal gyrusSleep dysfunction mediates the relationship between hypothalamic-insula connectivity and anxiety-depression symptom severity bidirectionally in young adults
Li G, Chen Y, Chaudhary S, Li C, Hao D, Yang L, Li C. Sleep dysfunction mediates the relationship between hypothalamic-insula connectivity and anxiety-depression symptom severity bidirectionally in young adults. NeuroImage 2023, 279: 120340. PMID: 37611815, DOI: 10.1016/j.neuroimage.2023.120340.Peer-Reviewed Original ResearchConceptsPittsburgh Sleep Quality IndexRight insulaSymptom severityMediation analysisSleep dysfunctionWhole-brain regressionHuman Connectome Project datasetSubjective mood stateYoung adultsState functional connectivityDepression symptom severityNegative emotionsCognitive performanceEmotional deficitsEmotional statesPotential sex differencesAffective functionsDrinking severityMood statesMotivated behaviorFunctional connectivityPoor sleep qualityRSFCSleep Quality IndexSleep qualityResting-State Functional Connectivity of the Dorsal and Ventral Striatum, Impulsivity, and Severity of Use in Recently Abstinent Cocaine-Dependent Individuals
Dong X, Zhornitsky S, Wang W, Le T, Chen Y, Chaudhary S, Li C, Zhang S. Resting-State Functional Connectivity of the Dorsal and Ventral Striatum, Impulsivity, and Severity of Use in Recently Abstinent Cocaine-Dependent Individuals. The International Journal Of Neuropsychopharmacology 2023, 26: 627-638. PMID: 37579016, PMCID: PMC10519818, DOI: 10.1093/ijnp/pyac019.Peer-Reviewed Original ResearchConceptsResting-state functional connectivityInferior frontal cortexCocaine-dependent individualsHealthy controlsVentral striatumCocaine useDorsal striatumAbstinent cocaine-dependent individualsCocaine misuseFunctional connectivityYears of drinkingLeft orbitofrontal cortexBIS-11 scoresRecent cocaine useLeft inferior frontal cortexDopaminergic deficitCortex connectivityFrontal cortexSeparate cohortHuman studiesSeverity of useAnimal studiesSecond cohortOrbitofrontal cortexBarratt Impulsivity ScaleImmune-Inflammatory Response And Compensatory Immune-Regulatory Reflex Systems And White Matter Integrity in Schizophrenia
Gou M, Chen W, Li Y, Chen S, Feng W, Pan S, Luo X, Tan S, Tian B, Li W, Tong J, Zhou Y, Li H, Yu T, Wang Z, Zhang P, Huang J, Kochunov P, Tian L, Li C, Hong L, Tan Y. Immune-Inflammatory Response And Compensatory Immune-Regulatory Reflex Systems And White Matter Integrity in Schizophrenia. Schizophrenia Bulletin 2023, 50: 199-209. PMID: 37540273, PMCID: PMC10754202, DOI: 10.1093/schbul/sbad114.Peer-Reviewed Original ResearchConceptsImmune-inflammatory response systemWhite matter integrityNegative symptom scoresFractional anisotropySymptom scoresAffected white matter tractsImmune inflammatory responsePanel of cytokinesWhite matter impairmentEnzyme-linked immunosorbentWhite matter tractsAverage fractional anisotropyWhite matter componentsPeripheral inflammationNeuroinflammatory conditionsPathophysiological mechanismsHealthy controlsCorpus callosumNegative symptomsReflex systemSchizophreniaOligodendrocyte differentiationConsistent findingComposite scoreUnderlying mechanismBrain volumes in alcohol use disorder: Do females and males differ? A whole‐brain magnetic resonance imaging mega‐analysis
Maggioni E, Rossetti M, Allen N, Batalla A, Bellani M, Chye Y, Cousijn J, Goudriaan A, Hester R, Hutchison K, Li C, Martin‐Santos R, Momenan R, Sinha R, Schmaal L, Solowij N, Suo C, van Holst R, Veltman D, Yücel M, Thompson P, Conrod P, Mackey S, Garavan H, Brambilla P, Lorenzetti V. Brain volumes in alcohol use disorder: Do females and males differ? A whole‐brain magnetic resonance imaging mega‐analysis. Human Brain Mapping 2023, 44: 4652-4666. PMID: 37436103, PMCID: PMC10400785, DOI: 10.1002/hbm.26404.Peer-Reviewed Original ResearchRelationships of in vivo brain norepinephrine transporter and age, BMI, and gender
Koohsari S, Sadabad F, Pittman B, Gallezot J, Carson R, van Dyck C, Li C, Potenza M, Matuskey D. Relationships of in vivo brain norepinephrine transporter and age, BMI, and gender. Synapse 2023, 77: e22279. PMID: 37382240, PMCID: PMC10416616, DOI: 10.1002/syn.22279.Peer-Reviewed Original ResearchConceptsBody mass indexMultilinear reference tissue model 2Gender-related differencesBrain norepinephrine transportersNorepinephrine transporterAge-related declineStructural MR scansBrain regionsReference tissue model 2Mass indexRaphe nucleusLocus coeruleusOccipital cortexBMI relationshipHealthy adultsHigh-resolution research tomographAvailable radiotracersHealthy participantsMR scansAgeAnatomic templateReference regionNegative associationNet availabilityPotential ageAge-related reduction in trait anxiety: Behavioral and neural evidence of automaticity in negative facial emotion processing
Chaudhary S, Zhang S, Zhornitsky S, Chen Y, Chao H, Li C. Age-related reduction in trait anxiety: Behavioral and neural evidence of automaticity in negative facial emotion processing. NeuroImage 2023, 276: 120207. PMID: 37263454, PMCID: PMC10330646, DOI: 10.1016/j.neuroimage.2023.120207.Peer-Reviewed Original ResearchConceptsFaster reaction timesNegative emotionsAge-related declineEmotional stimuliTrait anxietyAge-related reductionReaction timeEmotion regulation literatureSalient emotional stimuliPositive emotional stimuliFacial emotion processingPrefrontal cortical responsesRostral anterior cingulate cortexWhole-brain regressionAnterior cingulate activityDefault mode networkAnterior cingulate cortexEmotion regulationNeural evidenceEmotion processingDorsolateral PFCStimulus registrationDiminished anxietyPsychophysiological interactionEmotional circuitsOvernight Abstinence, Ventrostriatal-Insular Connectivity, and Tridimensional Personality Traits in Cigarette Smokers
Chen Y, Li C. Overnight Abstinence, Ventrostriatal-Insular Connectivity, and Tridimensional Personality Traits in Cigarette Smokers. Journal Of Integrative Neuroscience 2023, 22: 66. PMID: 37258442, DOI: 10.31083/j.jin2203066.Peer-Reviewed Original ResearchConceptsPersonality traitsOvernight abstinenceTridimensional Personality QuestionnaireState functional magnetic resonance imaging scansFunctional magnetic resonance imaging (fMRI) scansPersonality risk factorsIndividual personality traitsMagnetic resonance imaging (MRI) scansState functional connectivityShort-term abstinenceResonance imaging scansRisk of smokingInter-regional connectivityNicotine deprivationHarm avoidanceConnectivity correlatesNeural markersCigarette smokingFunctional connectivityCigarette smokersPersonality QuestionnaireImaging scansRisk factorsDorsal striatumNicotine dependenceThe effects of age on the severity of problem drinking: Mediating effects of positive alcohol expectancy and neural correlates
Chaudhary S, Chen Y, Zhornitsky S, Le T, Zhang S, Chao H, Dominguez J, Li C. The effects of age on the severity of problem drinking: Mediating effects of positive alcohol expectancy and neural correlates. Addiction Biology 2023, 28: e13278. PMID: 37252876, DOI: 10.1111/adb.13278.Peer-Reviewed Original ResearchConceptsPositive alcohol expectanciesAlcohol Use Disorders Identification TestAlcohol expectanciesAlcohol use disorderNeural correlatesCue responsesPath analysisProblem drinkingAlcohol misuseEffect of ageAUDIT scoresRostral anterior cingulate cortexWhole-brain regressionAlcohol cue exposureMiddle occipital cortexModerate alcohol use disorderAlcohol Expectancy QuestionnaireAnterior cingulate cortexAlcohol use severityBilateral rostral anterior cingulate cortexPsychological mechanismsBilateral parahippocampal gyrusCue exposureNeural processesSeverity of problemsInflammatory disequilibrium and lateral ventricular enlargement in treatment-resistant schizophrenia
Chen W, Gou M, Wang L, Li N, Li W, Tong J, Zhou Y, Xie T, Yu T, Feng W, Li Y, Chen S, Tian B, Tan S, Wang Z, Pan S, Luo X, Zhang P, Huang J, Tian L, Li C, Tan Y. Inflammatory disequilibrium and lateral ventricular enlargement in treatment-resistant schizophrenia. European Neuropsychopharmacology 2023, 72: 18-29. PMID: 37058967, DOI: 10.1016/j.euroneuro.2023.03.014.Peer-Reviewed Original ResearchConceptsAnti-inflammatory cytokinesInflammatory disequilibriumImmune-inflammatory response systemPlasma cytokine levelsTreatment-resistant schizophreniaLateral ventricular enlargementLarger lateral ventricle volumesPro-inflammatory cytokinesLateral ventricle volumeNegative Syndrome ScalePotential pathophysiological processesEnzyme-linked immunosorbentHigher PANSS scoresImmune imbalanceCytokine levelsT helperInflammatory imbalanceImmune biomarkersVentricular enlargementClinical manifestationsRegulatory cytokinesHealthy controlsPANSS scoresTh-17Subcortical volumes