2023
Machine Learning of Functional Connectivity to Biotype Alcohol and Nicotine Use Disorders
Zhu T, Wang W, Chen Y, Kranzler H, Li C, Bi J. Machine Learning of Functional Connectivity to Biotype Alcohol and Nicotine Use Disorders. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2023, 9: 326-336. PMID: 37696489, PMCID: PMC10976073, DOI: 10.1016/j.bpsc.2023.08.010.Peer-Reviewed Original ResearchNicotine use disorderHealthy controlsFunctional connectivity featuresUse disordersMagnetic resonance imagingNUD subjectsVisual cortexResonance imagingClinical metricsFunctional connectivityNoninvasive toolNeural phenotypesSample of individualsMulti-task learningTransdiagnostic approachUK BiobankReplication setGenetic profileMarkersReplication sampleHighest areaDisordersDepressionAUDBody of literature
2021
Lower prefrontal cortical synaptic vesicle binding in cocaine use disorder: An exploratory 11C‐UCB‐J positron emission tomography study in humans
Angarita GA, Worhunsky PD, Naganawa M, Toyonaga T, Nabulsi NB, Li C, Esterlis I, Skosnik PD, Radhakrishnan R, Pittman B, Gueorguieva R, Potenza MN, Finnema SJ, Huang Y, Carson RE, Malison RT. Lower prefrontal cortical synaptic vesicle binding in cocaine use disorder: An exploratory 11C‐UCB‐J positron emission tomography study in humans. Addiction Biology 2021, 27: e13123. PMID: 34852401, PMCID: PMC8891080, DOI: 10.1111/adb.13123.Peer-Reviewed Original ResearchConceptsCocaine use disorderAnterior cingulate cortexRecent cocaine useSynaptic densityMedial orbitofrontal cortexPrefrontal cortexCocaine useOrbitofrontal cortexUse disordersVentromedial prefrontal cortexPositron emission tomography scanPositron emission tomography studyEmission tomography scanSynaptic vesicle glycoprotein 2AHealthy control subjectsVolume of distributionEmission tomography studiesAcute cocaineControl subjectsTomography scanCocaine exposurePreclinical studiesHC subjectsDendritic spinesLifetime cocaine useCognitive dysfunction and cerebral volumetric deficits in individuals with Alzheimer's disease, alcohol use disorder, and dual diagnosis
Zhornitsky S, Chaudhary S, Le TM, Chen Y, Zhang S, Potvin S, Chao HH, van Dyck CH, Li CR. Cognitive dysfunction and cerebral volumetric deficits in individuals with Alzheimer's disease, alcohol use disorder, and dual diagnosis. Psychiatry Research Neuroimaging 2021, 317: 111380. PMID: 34482052, PMCID: PMC8579376, DOI: 10.1016/j.pscychresns.2021.111380.Peer-Reviewed Original ResearchConceptsAlcohol use disorderAlzheimer's diseaseHippocampal formationUse disordersHigher Clinical Dementia Rating Scale-SumVentricular volumeVolumetric deficitsCingulate cortexClinical Dementia Rating Scale SumCoordinating CenterSmaller hippocampal volumesLarger ventricular volumesNational Alzheimer's Coordinating CenterIsthmus cingulate cortexPosterior cingulate cortexMisuse of alcoholSuperior parietal cortexDistinct brain regionsCognitive dysfunctionHippocampal volumeInferior frontal gyrusRegional GMVHigh riskDementia severityDual diagnosisA Multimodal Mobile Sleep Intervention for Young Adults Engaged in Risky Drinking: Protocol for a Randomized Controlled Trial (Preprint)
Fucito LM, Ash GI, DeMartini KS, Pittman B, Barnett NP, Li CR, Redeker NS, O'Malley SS. A Multimodal Mobile Sleep Intervention for Young Adults Engaged in Risky Drinking: Protocol for a Randomized Controlled Trial (Preprint). JMIR Research Protocols 2021, 10: e26557. PMID: 33635276, PMCID: PMC7954653, DOI: 10.2196/26557.Peer-Reviewed Original ResearchSleep hygiene adviceINTERNATIONAL REGISTERED REPORT IDENTIFIERHeavy-drinking young adultsHygiene adviceSleep interventionsYoung adultsAlcohol diaryAlcohol use disorder riskRisky alcohol consumptionAlcohol use disorderLow-cost interventionAlcohol behavior changeControlled TrialsWeb-based sessionsBrief adviceHealth coachesRisk factorsPoor sleepRecent heavy drinkingSleep characteristicsUse disordersAlcohol consumptionAlcohol-related consequencesPriority populationsSecondary aim
2018
Mega-Analysis of Gray Matter Volume in Substance Dependence: General and Substance-Specific Regional Effects
Mackey S, Allgaier N, Chaarani B, Spechler P, Orr C, Bunn J, Allen NB, Alia-Klein N, Batalla A, Blaine S, Brooks S, Caparelli E, Chye YY, Cousijn J, Dagher A, Desrivieres S, Feldstein-Ewing S, Foxe JJ, Goldstein RZ, Goudriaan AE, Heitzeg MM, Hester R, Hutchison K, Korucuoglu O, Li CR, London E, Lorenzetti V, Luijten M, Martin-Santos R, May A, Momenan R, Morales A, Paulus MP, Pearlson G, Rousseau ME, Salmeron BJ, Schluter R, Schmaal L, Schumann G, Sjoerds Z, Stein DJ, Stein EA, Sinha R, Solowij N, Tapert S, Uhlmann A, Veltman D, van Holst R, Whittle S, Wiers R, Wright M, Yücel M, Zhang S, Yurgelun-Todd D, Hibar D, Jahanshad N, Evans A, Thompson P, Glahn D, Conrod P, Garavan H. Mega-Analysis of Gray Matter Volume in Substance Dependence: General and Substance-Specific Regional Effects. American Journal Of Psychiatry 2018, 176: 119-128. PMID: 30336705, PMCID: PMC6427822, DOI: 10.1176/appi.ajp.2018.17040415.Peer-Reviewed Original ResearchConceptsRegional brain volumesControl subjectsSubstance dependenceBrain volumeBrain regionsLower brain volumeAlcohol use disorderGray matter volumeTotal intracranial volumeMedial orbitofrontal cortexCommon neural substrateCortical thicknessUse disordersUseful biomarkerMatter volumeSubcortical volumesImaging biomarkersAlcohol dependenceIntracranial volumeOrbitofrontal cortexRegional volumesBrain structuresRelevant imaging biomarkersLow volumeNeural substratesThalamic Cortical Error–Related Responses in Adult Social Drinkers: Sex Differences and Problem Alcohol Use
Ide JS, Zhornitsky S, Chao HH, Zhang S, Hu S, Wang W, Krystal JH, Li CR. Thalamic Cortical Error–Related Responses in Adult Social Drinkers: Sex Differences and Problem Alcohol Use. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2018, 3: 868-877. PMID: 29859929, PMCID: PMC6177312, DOI: 10.1016/j.bpsc.2018.04.008.Peer-Reviewed Original ResearchConceptsWhole-brain linear regressionError-related activationSex differencesBilateral dorsal anterior cingulate cortexAlcohol Use Disorders Identification Test (AUDIT) scoresSocial drinkersDorsal anterior cingulate cortexSubstance use disordersAnterior cingulate cortexFunctional magnetic resonance imagingMagnetic resonance imagingSuperior temporal cortexStatistical parametric mappingProblem alcohol useBilateral thalamusAlcohol drinkersAdult social drinkersStop-signal taskMale social drinkersTemporal cortexUse disordersCerebral activationIndependent sample t-testCingulate cortexSubcortical regions
2007
Neural Correlates of Impulse Control During Stop Signal Inhibition in Cocaine-Dependent Men
Li CS, Huang C, Yan P, Bhagwagar Z, Milivojevic V, Sinha R. Neural Correlates of Impulse Control During Stop Signal Inhibition in Cocaine-Dependent Men. Neuropsychopharmacology 2007, 33: 1798-1806. PMID: 17895916, PMCID: PMC2731999, DOI: 10.1038/sj.npp.1301568.Peer-Reviewed Original ResearchConceptsRostral anterior cingulate cortexCocaine-dependent menFunctional magnetic resonance imagingCocaine dependenceResponse inhibitionNeural correlatesHealthy control subjectsRisk of relapsePre-supplementary motor areaSubstance use disordersAnterior cingulate cortexImpulse controlSignal inhibitionMagnetic resonance imagingUseful neural markersStop-signal inhibitionRelative hypoactivationMale patientsControl subjectsSignal reaction timeMotor areaYears of educationUse disordersCingulate cortexResonance imaging