Diminished gray matter density mediates chemotherapy dosage-related cognitive impairment in breast cancer patients
Li X, Chen H, Lv Y, Chao HH, Gong L, Li CR, Cheng H. Diminished gray matter density mediates chemotherapy dosage-related cognitive impairment in breast cancer patients. Scientific Reports 2018, 8: 13801. PMID: 30218006, PMCID: PMC6138678, DOI: 10.1038/s41598-018-32257-w.Peer-Reviewed Original ResearchConceptsBreast cancer patientsGray matter densityRight middle frontal gyrusBC patientsCancer patientsCognitive impairmentMiddle frontal gyrusChemotherapy cyclesFrontal gyrusWhole brainGray matterMorphometry analysisHealthy control subjectsStructural magnetic resonance imagingDose-response relationshipMagnetic resonance imagingRight fusiform areaFrontal cortical structuresControl subjectsBilateral cerebellumInferior frontal gyrusPatientsLeft inferior frontal gyrusResonance imagingBrain structures