2021
An independent, replicable, functional and significant risk variant block at intron 3 of CACNA1C for schizophrenia
Wang Z, Chen W, Cao Y, Dou Y, Fu Y, Zhang Y, Luo X, Kang L, Liu N, Shi YS, Li CR, Xu Y, Guo X, Luo X. An independent, replicable, functional and significant risk variant block at intron 3 of CACNA1C for schizophrenia. Australian & New Zealand Journal Of Psychiatry 2021, 56: 385-397. PMID: 33938268, DOI: 10.1177/00048674211009595.Peer-Reviewed Original ResearchConceptsMessenger RNA expressionGray matter volumeMatter volumeSingle nucleotide polymorphismsRisk allelesRNA expressionPathogenesis of schizophreniaSingle nucleotide polymorphism (SNP) rs1006737Isthmus cingulate cortexMinor allele ARisk single nucleotide polymorphismsBrain cohortCingulate cortexBrain regionsCortical regionsSubcortical structuresSchizophreniaRs1006737Allele ARegulatory effectsRisk genesSignificant risk genesCohortCortexAfrican American sample
2020
Replicated risk CACNA1C variants for major psychiatric disorders may serve as potential therapeutic targets for the shared depressive endophenotype.
Guo X, Fu Y, Zhang Y, Wang T, Lu L, Luo X, Wang K, Huang J, Xie T, Zheng C, Yang K, Tong J, Zuo L, Kang L, Tan Y, Jiang K, Li CR, Luo X. Replicated risk CACNA1C variants for major psychiatric disorders may serve as potential therapeutic targets for the shared depressive endophenotype. 2020, 4 PMID: 34046650, PMCID: PMC8153461.Peer-Reviewed Original ResearchMajor psychiatric disordersGenome-wide association studiesL-type voltage-gated calcium channelsMajor depressive disorderMRNA expression regulationPsychiatric disordersTherapeutic targetBipolar disorderChronic mild stress (CMS) ratsHuman hippocampusExpression regulationDepressive endophenotypeType voltage-gated calcium channelsRole of venlafaxineVoltage-gated calcium channelsPotential therapeutic targetRisk genesSignificant mRNA expressionVenlafaxine treatmentDepressive disorderStress ratsDepressive symptomsIndependent cohortCalcium channelsMRNA expression
2016
Replicated Risk Nicotinic Cholinergic Receptor Genes for Nicotine Dependence
Zuo L, Garcia-Milian R, Guo X, Zhong C, Tan Y, Wang Z, Wang J, Wang X, Kang L, Lu L, Chen X, Li CR, Luo X. Replicated Risk Nicotinic Cholinergic Receptor Genes for Nicotine Dependence. Genes 2016, 7: 95. PMID: 27827986, PMCID: PMC5126781, DOI: 10.3390/genes7110095.Peer-Reviewed Original ResearchNicotinic cholinergic receptor genesRisk genesRisk variantsCholinergic receptor genesReceptor geneMouse brainGenomic regionsEQTL analysisBioinformatics analysisProtein structureNicotinic acetylcholine receptorsGenesMouse brain samplesGenetic variantsAcetylcholine receptorsIndependent humanExpressionPotential functionVariantsImportant roleSplicingTranscriptionBrain samplesCHRNA5-A3RNAAssociations of rare nicotinic cholinergic receptor gene variants to nicotine and alcohol dependence
Zuo L, Tan Y, Li C, Wang Z, Wang K, Zhang X, Lin X, Chen X, Zhong C, Wang X, Wang J, Lu L, Luo X. Associations of rare nicotinic cholinergic receptor gene variants to nicotine and alcohol dependence. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2016, 171: 1057-1071. PMID: 27473937, PMCID: PMC5587505, DOI: 10.1002/ajmg.b.32476.Peer-Reviewed Original ResearchMeSH KeywordsAlcoholismAnimalsBlack or African AmericanCase-Control StudiesDatabases, Nucleic AcidFemaleGene FrequencyGenetic Predisposition to DiseaseGenetic VariationGenome-Wide Association StudyHumansMaleMiceNicotinePolymorphism, Single NucleotideReceptors, NicotinicTobacco Use DisorderWhite PeopleConceptsCHRN genesGenomic regionsNicotine dependenceAD risk genesAlcohol dependenceRare variantsNicotinic cholinergic receptor genesRewarding effectsDistinct subunitsMouse brainGenesMicroarray platformRisk genesNicotine's rewarding effectsCholinergic receptor genesReceptor geneSpecific brain areasDifferent neuropsychiatric disordersIndependent cohortDiscrete regionsWhole mouse brainBrain areasNeuropsychiatric disordersMRNA expressionBrain
2011
Genome-Wide Association Study of Alcohol Dependence Implicates KIAA0040 on Chromosome 1q
Zuo L, Gelernter J, Zhang CK, Zhao H, Lu L, Kranzler HR, Malison RT, Li CS, Wang F, Zhang XY, Deng HW, Krystal JH, Zhang F, Luo X. Genome-Wide Association Study of Alcohol Dependence Implicates KIAA0040 on Chromosome 1q. Neuropsychopharmacology 2011, 37: 557-566. PMID: 21956439, PMCID: PMC3242317, DOI: 10.1038/npp.2011.229.Peer-Reviewed Original ResearchConceptsSignificant risk genesHapMap populationsGenome-wide association analysisExpression quantitative trait loci (eQTL) analysisGenome-wide association study data setsQuantitative trait locus (QTL) analysisAssociation analysisMetabolic pathwaysRisk genesGenome-wide association studiesSNP-expression associationsCis-acting regulatory effectsExtracellular matrix proteinsGene expression levelsNumerous genesSignificant SNPsCausal variantsKIAA0040Risk lociRisk of ADLocus analysisAssociation studiesMatrix proteinsRisk SNPsCell migration