2019
Transcriptome-wide piRNA profiling in human brains for aging genetic factors.
Mao Q, Fan L, Wang X, Lin X, Cao Y, Zheng C, Zhang Y, Zhang H, Garcia-Milian R, Kang L, Shi J, Yu T, Wang K, Zuo L, Li CR, Guo X, Luo X. Transcriptome-wide piRNA profiling in human brains for aging genetic factors. 2019, 4 PMID: 32149191, PMCID: PMC7059831.Peer-Reviewed Original ResearchPIWI-interacting RNAsTransposable elementsAge-associated genesCritical genetic determinantsGenomic integrityExpression regulationCancer stem cellsMicroarray technologyGenetic determinantsStem cellsExpression levelsRenewal capacityMolecular featuresBiological systemsPotential roleGenetic factorsYears of survivalUnderlying mechanismHuman prefrontal cortexGermlineGenesRNADisease statusMultiple testingPrefrontal cortex
2016
Replicated Risk Nicotinic Cholinergic Receptor Genes for Nicotine Dependence
Zuo L, Garcia-Milian R, Guo X, Zhong C, Tan Y, Wang Z, Wang J, Wang X, Kang L, Lu L, Chen X, Li CR, Luo X. Replicated Risk Nicotinic Cholinergic Receptor Genes for Nicotine Dependence. Genes 2016, 7: 95. PMID: 27827986, PMCID: PMC5126781, DOI: 10.3390/genes7110095.Peer-Reviewed Original ResearchNicotinic cholinergic receptor genesRisk genesRisk variantsCholinergic receptor genesReceptor geneMouse brainGenomic regionsEQTL analysisBioinformatics analysisProtein structureNicotinic acetylcholine receptorsGenesMouse brain samplesGenetic variantsAcetylcholine receptorsIndependent humanExpressionPotential functionVariantsImportant roleSplicingTranscriptionBrain samplesCHRNA5-A3RNA