Effects of microRNA-181b-5p on cognitive deficits in first-episode patients with schizophrenia: Mediated by BCL-2
Gou M, Pan S, Tong J, Zhou Y, Han J, Xie T, Yu T, Feng W, Li Y, Chen S, Cui Y, Tian B, Tan MDS, Wang Z, Luo X, Li CR, Zhang P, Huang J, Hong LE, Tan Y, Tian L. Effects of microRNA-181b-5p on cognitive deficits in first-episode patients with schizophrenia: Mediated by BCL-2. Journal Of Psychiatric Research 2021, 136: 358-365. PMID: 33636692, DOI: 10.1016/j.jpsychires.2021.02.003.Peer-Reviewed Original ResearchConceptsFirst-episode patientsBcl-2 mRNAEnzyme Linked Immunosorbent AssayMATRICS Consensus Cognitive BatteryQuantitative real-time PCRCognitive deficitsCognitive functionGender-matched healthy controlsBcl-2Pathogenesis of schizophreniaPeripheral whole bloodExpression levelsNegative Syndrome ScaleBcl-2 protein expressionLinked Immunosorbent AssayBcl-2 protein levelsPeripheral bloodHealthy controlsBcl-2 mRNA levelsReal-time PCRTarget genes Bcl-2Consensus Cognitive BatterySchizophrenia patientsSyndrome ScaleGene Bcl-2