2024
Olfactory Development and Dysfunction - Involvement of Microglia
Meller S, Greer C. Olfactory Development and Dysfunction - Involvement of Microglia. Physiology 2024 PMID: 39499248, DOI: 10.1152/physiol.00037.2024.Peer-Reviewed Original ResearchInvolvement of microgliaPotential involvement of microgliaOlfactory developmentImmune responseOlfactory deficitsEnvironmental insultsResponse to environmental insultsMicroglia-mediated immune responseOlfactory lossOlfactory systemPeriod of neurogenesisNeuronal migrationPotential involvementMicrogliaDiseaseViral diseasesInsultOlfactoryDeficitsInflammatory Response and Defects on Myelin Integrity in the Olfactory System of K18hACE2 Mice Infected with SARS-CoV-2
Martin-Lopez E, Brennan B, Mao T, Spence N, Meller S, Han K, Yahiaoui N, Wang C, Iwasaki A, Greer C. Inflammatory Response and Defects on Myelin Integrity in the Olfactory System of K18hACE2 Mice Infected with SARS-CoV-2. ENeuro 2024, 11: eneuro.0106-24.2024. PMID: 38834299, PMCID: PMC11185043, DOI: 10.1523/eneuro.0106-24.2024.Peer-Reviewed Original ResearchOlfactory bulbOlfactory epitheliumPiriform cortexOlfactory tractOlfactory systemSARS-CoV-2Projection neuronsMyelination defectsOlfactory sensory neuronsLateral olfactory tractLoss of olfactionRespiratory epithelial cellsLamina propria macrophagesSARS-CoV-2 infectionInfected SCDays of infectionIntegrity of myelinOlfactory dysfunctionInfected microgliaSensitive to infectionOlfactory deficitsSensory neuronsSustentacular cellsNasal cavityNeuronal conduction
2015
Dendrodendritic synapses in the mouse olfactory bulb external plexiform layer
Bartel DL, Rela L, Hsieh L, Greer CA. Dendrodendritic synapses in the mouse olfactory bulb external plexiform layer. The Journal Of Comparative Neurology 2015, 523: 1145-1161. PMID: 25420934, PMCID: PMC4390432, DOI: 10.1002/cne.23714.Peer-Reviewed Original ResearchConceptsExternal plexiform layerDendrodendritic synapsesPlexiform layerSynaptic densityOlfactory bulb projection neuronsReciprocal dendrodendritic synapsesGranule cell spinesPostsynaptic scaffolding proteinOdor informationIR punctaProjection neuronsSecondary dendritesInhibitory synapsesT cellsInhibitory inputsCell synapseGranule cellsSynaptic circuitsSynaptic propertiesCell bodiesSynapsesCurrent spreadDendritesSynapseTemporal coding
2014
Segregated labeling of olfactory bulb projection neurons based on their birthdates
Imamura F, Greer CA. Segregated labeling of olfactory bulb projection neurons based on their birthdates. European Journal Of Neuroscience 2014, 41: 147-156. PMID: 25393912, PMCID: PMC4300262, DOI: 10.1111/ejn.12784.Peer-Reviewed Original ResearchConceptsExternal plexiform layerMitral cell layerOlfactory bulb projection neuronsSuperficial external plexiform layerProjection neuronsMitral cellsOlfactory bulbInnervation patternSoma locationOB projection neuronsMain olfactory bulbAccessory olfactory bulbMouse olfactory bulbTiming of neurogenesisSecondary dendritesPlexiform layerCell dendritesBrdU injectionLaminar organizationUtero electroporationNeuronsDistinct subsetsEmbryonic dayCell layerMitralNonsensory target-dependent organization of piriform cortex
Chen CF, Zou DJ, Altomare CG, Xu L, Greer CA, Firestein SJ. Nonsensory target-dependent organization of piriform cortex. Proceedings Of The National Academy Of Sciences Of The United States Of America 2014, 111: 16931-16936. PMID: 25385630, PMCID: PMC4250170, DOI: 10.1073/pnas.1411266111.Peer-Reviewed Original ResearchConceptsPiriform cortexOrbitofrontal cortexMouse piriform cortexOutput neuronsPrimary sensory cortexAssociation fiber systemsFluorescent retrograde tracingLateral orbitofrontal cortexRetrograde tracingEfferent componentsEfferent pathwaysAfferent inputEfferent projectionsOlfactory cortexOlfactory bulbAgranular insulaSensory cortexEfferent circuitsCortexOlfactory learning promotes input-specific synaptic plasticity in adult-born neurons
Lepousez G, Nissant A, Bryant AK, Gheusi G, Greer CA, Lledo PM. Olfactory learning promotes input-specific synaptic plasticity in adult-born neurons. Proceedings Of The National Academy Of Sciences Of The United States Of America 2014, 111: 13984-13989. PMID: 25189772, PMCID: PMC4183341, DOI: 10.1073/pnas.1404991111.Peer-Reviewed Original ResearchConceptsAdult-born granule cellsAdult-born neuronsInput-specific synaptic plasticityOlfactory bulbGranule cellsOlfactory cortexSynaptic plasticityOptogenetic stimulationOlfactory learningSelective optogenetic stimulationOlfactory information processingCircuit remodelingCortical projectionsSpine densityAdult neurogenesisOB neuronsNew neuronsExcitatory inputsInhibitory inputsSynaptic mechanismsDendritic portionsDendritic treeNeuronsFunctional plasticityElectrophysiological analysis
2013
Pax6 regulates Tbr1 and Tbr2 expressions in olfactory bulb mitral cells
Imamura F, Greer CA. Pax6 regulates Tbr1 and Tbr2 expressions in olfactory bulb mitral cells. Molecular And Cellular Neuroscience 2013, 54: 58-70. PMID: 23353076, PMCID: PMC3622182, DOI: 10.1016/j.mcn.2013.01.002.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDNA-Binding ProteinsDopaminergic NeuronsEye ProteinsGABAergic NeuronsGene Expression Regulation, DevelopmentalHomeodomain ProteinsInterneuronsMiceMitosisNeural Stem CellsNeurogenesisNeurogliaOlfactory BulbPaired Box Transcription FactorsPAX6 Transcription FactorRepressor ProteinsT-Box Domain ProteinsConceptsExogenous expressionRegulation of Pax6Expression of Tbr1Mitral cell developmentCell precursorsFate determinationCell fateRadial glial cellsMitral cellsCell developmentTbr2 expressionPax6Embryonic olfactory bulbCortical projection neuronsOlfactory bulb mitral cellsPostmitotic precursorsPrecursor cellsUtero electroporationVentricular zoneNumber of cellsDopaminergic interneuronsTbr1Projection neuronsExpressionGlial cells
2011
Timing of neurogenesis is a determinant of olfactory circuitry
Imamura F, Ayoub AE, Rakic P, Greer CA. Timing of neurogenesis is a determinant of olfactory circuitry. Nature Neuroscience 2011, 14: 331-337. PMID: 21297629, PMCID: PMC3046046, DOI: 10.1038/nn.2754.Peer-Reviewed Original Research
2010
Developmental Dynamics of Piriform Cortex
Sarma AA, Richard MB, Greer CA. Developmental Dynamics of Piriform Cortex. Cerebral Cortex 2010, 21: 1231-1245. PMID: 21041199, PMCID: PMC3140179, DOI: 10.1093/cercor/bhq199.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAnalysis of VarianceAnimalsAnimals, NewbornBromodeoxyuridineCell DifferentiationCerebral CortexEmbryo, MammalianFemaleGene Expression Regulation, DevelopmentalGlutamate DecarboxylaseGreen Fluorescent ProteinsIndolesMiceMice, TransgenicNerve Tissue ProteinsNeuronsNonlinear DynamicsPregnancyRatsConceptsAnterior piriform cortexPiriform cortexPyramidal cellsLayers IIPostnatal developmentCortical sensory processingNumber of interneuronsMolecular maturationCortical laminationInhibitory synapsesPostnatal eventsInhibitory networksSensory processingOdor codingPaleocortexCortexMorphological basisCellsMaturationInterneuronsNeocortexSynapsesAge-induced disruption of selective olfactory bulb synaptic circuits
Richard MB, Taylor SR, Greer CA. Age-induced disruption of selective olfactory bulb synaptic circuits. Proceedings Of The National Academy Of Sciences Of The United States Of America 2010, 107: 15613-15618. PMID: 20679234, PMCID: PMC2932573, DOI: 10.1073/pnas.1007931107.Peer-Reviewed Original ResearchConceptsMouse OBLayer-specific alterationsAfferent synaptic inputExternal plexiform layerPrimary sensory cortexAge-related alterationsAge-related cognitive deficitsNeuronal lossOlfactory bulb circuitryProjection neuronsPlexiform layerOB glomeruliQuantitative morphometric analysisSynaptic densityGlomerular layerInterneuron subpopulationsOlfactory functionOSN axonsSynaptic inputsSensory cortexOB layersSynaptic circuitsSensory functionOB circuitryCognitive deficits
2009
Dendritic Branching of Olfactory Bulb Mitral and Tufted Cells: Regulation by TrkB
Imamura F, Greer CA. Dendritic Branching of Olfactory Bulb Mitral and Tufted Cells: Regulation by TrkB. PLOS ONE 2009, 4: e6729. PMID: 19707543, PMCID: PMC2727791, DOI: 10.1371/journal.pone.0006729.Peer-Reviewed Original ResearchConceptsMitral/TrkB activationOlfactory bulbApical dendritesDendritic developmentLateral dendriteDendritic branchingExternal plexiform layerReciprocal dendrodendritic synapsesEarly postnatal daysOlfactory bulb mitralTrkB neurotrophin receptorMammalian olfactory bulbSame odor receptorOlfactory sensory neuronsTufted CellsDendrodendritic synapsesTrkB receptorsDendritic differentiationOB neuronsProjection neuronsPlexiform layerNeurotrophin receptorPostnatal daySensory neurons
2007
Synaptic Integration of Adult-Generated Olfactory Bulb Granule Cells: Basal Axodendritic Centrifugal Input Precedes Apical Dendrodendritic Local Circuits
Whitman MC, Greer CA. Synaptic Integration of Adult-Generated Olfactory Bulb Granule Cells: Basal Axodendritic Centrifugal Input Precedes Apical Dendrodendritic Local Circuits. Journal Of Neuroscience 2007, 27: 9951-9961. PMID: 17855609, PMCID: PMC6672649, DOI: 10.1523/jneurosci.1633-07.2007.Peer-Reviewed Original ResearchConceptsExternal plexiform layerGranule cell layerAdult-generated granule cellsGranule cellsOlfactory bulbSynaptic integrationLocal circuitsOlfactory bulb granule cellsNew granule cellsSubventricular zone migrateAdult mammalian olfactory bulbMammalian olfactory bulbElaborate dendritic arborsBasal dendritesPostsynaptic markersAxon collateralsSynaptic markersPlexiform layerPeriglomerular cellsDendritic arborsMitral/Spine increasesDendritic spinesNew interneuronsD postinfection