Growth-Promoting Interaction of IGF-II with the Insulin Receptor during Mouse Embryonic Development
Louvi A, Accili D, Efstratiadis A. Growth-Promoting Interaction of IGF-II with the Insulin Receptor during Mouse Embryonic Development. Developmental Biology 1997, 189: 33-48. PMID: 9281335, DOI: 10.1006/dbio.1997.8666.Peer-Reviewed Original ResearchConceptsInsulin receptorGrowth-promoting interactionsMouse embryonic developmentMouse embryonic growthLigand/receptor interactionsGrowth-promoting functionEmbryonic day 13.5IGF-IINull mutantsTargeted MutagenesisGrowth of embryosMouse embryogenesisDouble mutantTriple mutantEmbryonic developmentGenetic evidenceIGF1R resultsOrgan hypoplasiaGenetic analysisMutantsEmbryonic growthType 1 IGF receptorDay 13.5Receptor interactionEmbryosInsulin-like growth factor II stimulates cell proliferation through the insulin receptor
Morrione A, Valentinis B, Xu S, Yumet G, Louvi A, Efstratiadis A, Baserga R. Insulin-like growth factor II stimulates cell proliferation through the insulin receptor. Proceedings Of The National Academy Of Sciences Of The United States Of America 1997, 94: 3777-3782. PMID: 9108054, PMCID: PMC20517, DOI: 10.1073/pnas.94.8.3777.Peer-Reviewed Original ResearchConceptsInsulin receptorSerum-free mediumType 1 insulin-like growth factor receptorCell proliferationInsulin-like growth factor receptorR cellsIGF-IIWild-type counterpartsGrowth factor receptorGrowth factor supplementationInsulin-like growth factor IITargeted disruptionFactor receptorGrowth factor IIFactor supplementationGrowth factorPlasmidAdditional plasmidsCellsReceptorsFactor IIProliferationGenesIGF1RFibroblasts