2024
Support vector machine prediction of individual Autism Diagnostic Observation Schedule (ADOS) scores based on neural responses during live eye-to-eye contact
Zhang X, Noah J, Singh R, McPartland J, Hirsch J. Support vector machine prediction of individual Autism Diagnostic Observation Schedule (ADOS) scores based on neural responses during live eye-to-eye contact. Scientific Reports 2024, 14: 3232. PMID: 38332184, PMCID: PMC10853508, DOI: 10.1038/s41598-024-53942-z.Peer-Reviewed Original ResearchConceptsAutism Diagnostic Observation ScheduleAutism spectrum disorderAutism Diagnostic Observation Schedule scoresEye-to-eye contactSocial difficultiesNeural processesNeural responsesObservation ScheduleSymptoms of autism spectrum disorderBehavioural symptoms of autism spectrum disorderNeural activity patternsLive interaction paradigmTD groupSupport vector machineNeural mechanismsSymptom severityADOS scoresBehavioral symptomsSpectrum disorderASD diagnosisNeural dataActivity patternsAutismClassification methodMultivariate classification methods
2022
Neural correlates of eye contact and social function in autism spectrum disorder
Hirsch J, Zhang X, Noah J, Dravida S, Naples A, Tiede M, Wolf J, McPartland J. Neural correlates of eye contact and social function in autism spectrum disorder. PLOS ONE 2022, 17: e0265798. PMID: 36350848, PMCID: PMC9645655, DOI: 10.1371/journal.pone.0265798.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderDorsal parietal regionsNeural correlatesEye contactLive eyesNeural responsesSpectrum disorderAutism Diagnostic Observation ScheduleUnderlying neural correlatesSocial Responsiveness ScaleGold standard measureCentral diagnostic criterionDiagnostic criteriaDiagnostic biomarkersSRS-2ADOS-2Responsiveness ScaleObservation ScheduleParietal regionsPupillometry dataNeural systemsEyesNatural interactionDisordersCorrelates
2020
Autism Spectrum Disorder and Schizophrenia Are Better Differentiated by Positive Symptoms Than Negative Symptoms
Trevisan DA, Foss-Feig JH, Naples AJ, Srihari V, Anticevic A, McPartland JC. Autism Spectrum Disorder and Schizophrenia Are Better Differentiated by Positive Symptoms Than Negative Symptoms. Frontiers In Psychiatry 2020, 11: 548. PMID: 32595540, PMCID: PMC7301837, DOI: 10.3389/fpsyt.2020.00548.Peer-Reviewed Original ResearchAutism spectrum disorderSpectrum disorderNegative symptomsAutism Diagnostic Observation SchedulePositive symptomsGold standard diagnostic assessmentHeterogenous neurodevelopmental disorderAnalysis of covarianceDSM-5 criteriaStereotyped languageTD adultsASD symptomsTypical developmentObservation ScheduleRepetitive behaviorsCommunicative behaviorNegative Syndrome ScaleStandardized measuresSZ groupSymptom domainsGroup differencesParticipant groupsSymptom overlapSZ symptomsNeurodevelopmental disorders