2024
Thrombolytic Therapy for Venous Thromboembolism in the Pediatric Population: A Systematic Review and Meta-Analysis
Kawtharany H, Azzam M, Monagle P, Bercovitz R, Alkhader A, Hamarsha Q, Zeid H, Mansour R, Tabak C, Patel P, Baghdadi S, Betensky M, Bhat R, Biss T, Branchford B, Brandao L, Chan A, Faustino E, Jaffray J, Jones S, Kerlin B, Kucine N, Kumar R, Male C, Pelland-Marcotte M, Raffini L, Raulji C, Sartain S, Takemoto C, Tarango C, Van Ommen H, Velez M, Vesely S, Wiernikowski J, Williams S, Wilson H, Woods G, Zia A, Mustafa R. Thrombolytic Therapy for Venous Thromboembolism in the Pediatric Population: A Systematic Review and Meta-Analysis. Blood 2024, 144: 2633. DOI: 10.1182/blood-2024-212166.Peer-Reviewed Original ResearchRate of thrombus resolutionAbsolute riskRisk of biasCertainty of evidenceMassive PEThrombolytic therapyPediatric patientsOutcome of thrombolysisAC groupPulmonary embolismSystematic reviewThrombus resolutionCovidence systematic review softwareRisk of thrombosis recurrenceThrombolysis groupMeta-analysisConcerns related to riskSystematic review softwareSubmassive pulmonary embolismChronic pulmonary hypertensionManagement of VTERestoring venous patencyRisk of progressionCochrane Central Register of Controlled TrialsCentral Register of Controlled TrialsConsiderations for instituting pediatric pulmonary embolism response teams: A tool kit
Rajpurkar M, Rosovsky R, Williams S, Chan A, van Ommen C, Faustino E, White M, Parikh M, Sirachainan N, Biss T, Goldenberg N. Considerations for instituting pediatric pulmonary embolism response teams: A tool kit. Thrombosis Research 2024, 236: 97-107. PMID: 38417301, DOI: 10.1016/j.thromres.2024.02.019.Peer-Reviewed Original ResearchPulmonary Embolism Response TeamPediatric pulmonary embolismPediatric PETime to diagnosisIndividual physician's experiencePulmonary embolismDefinitive managementPE patientsResponse teamCritical care pathwayEpidemiological featuresCare pathwaysPhysician experiencePractice guidelinesPE outcomesDiagnosisCritical pathways
2023
Hospital-acquired venous thromboembolism during invasive mechanical ventilation in children: a single-center, retrospective cohort study
Havlicek E, Goldman Z, Faustino E, Ignjatovic V, Goldenberg N, Sochet A. Hospital-acquired venous thromboembolism during invasive mechanical ventilation in children: a single-center, retrospective cohort study. Journal Of Thrombosis And Haemostasis 2023, 21: 3145-3152. PMID: 37423387, DOI: 10.1016/j.jtha.2023.06.035.Peer-Reviewed Original ResearchConceptsHospital-acquired venous thromboembolismInvasive mechanical ventilationRetrospective cohort studyVenous thromboembolismMechanical ventilationEndotracheal intubationCohort studyIll childrenRisk factorsGeneral pediatric intensive care unit populationPediatric intensive care unit populationConcurrent central venous cathetersIntensive care unit populationExtremity deep venous thrombosisPediatric intensive care unitHypercoagulability risk factorsDeep venous thrombosisCentral venous cathetersIntensive care unitEligible encountersIMV durationPulmonary embolismSecondary outcomesVenous cathetersPrimary outcome
2022
Mechanical Ventilation and Hospital-Acquired Venous Thromboembolism Among Critically Ill Children.
Sochet A, Havlicek E, Faustino E, Goldenberg N. Mechanical Ventilation and Hospital-Acquired Venous Thromboembolism Among Critically Ill Children. Hospital Pediatrics 2022, 12: 1099-1109. PMID: 36349533, DOI: 10.1542/hpeds.2022-006697.Peer-Reviewed Original ResearchConceptsHospital-acquired venous thromboembolismDeep venous thrombosisMechanical ventilationMultivariable logistic regressionIll childrenVenous thromboembolismCohort studyVenous thrombosisRegistry-based cohort studyExtremity deep venous thrombosisLogistic regressionHA-VTE eventsInvasive mechanical ventilationRetrospective cohort studyVTE risk factorsCentral venous catheterizationYears of ageHospital dischargePulmonary embolismPrimary outcomeVenous catheterizationRisk factorsClinical trialsProspective validationSystem registry