2023
IL-6 trans-signaling in a humanized mouse model of scleroderma
Odell I, Agrawal K, Sefik E, Odell A, Caves E, Kirkiles-Smith N, Horsley V, Hinchcliff M, Pober J, Kluger Y, Flavell R. IL-6 trans-signaling in a humanized mouse model of scleroderma. Proceedings Of The National Academy Of Sciences Of The United States Of America 2023, 120: e2306965120. PMID: 37669366, PMCID: PMC10500188, DOI: 10.1073/pnas.2306965120.Peer-Reviewed Original ResearchConceptsBone marrow-derived immune cellsIL-6Human hematopoietic stem cellsImmune cellsT cellsScleroderma skinSoluble IL-6 receptorCD8 T cellsHumanized mouse modelPathogenesis of sclerodermaMesenchymal cellsFibroblast-derived IL-6IL-6 receptorIL-6 signalingT cell activationHuman IL-6Human T cellsExpression of collagenFibrosis improvementPansclerotic morpheaHuman endothelial cellsHumanized miceReduced markersSkin graftsHuman CD4
2010
Human Thrombopoietin Knockin Mice Efficiently Support Human Hematopoiesis In Vivo
Rongvaux A, Willinger T, Takizawa H, Rathinam C, Eynon E, Stevens S, Manz M, Flavell R. Human Thrombopoietin Knockin Mice Efficiently Support Human Hematopoiesis In Vivo. Blood 2010, 116: 403. DOI: 10.1182/blood.v116.21.403.403.Peer-Reviewed Original ResearchHematopoietic stem cellsHuman hematopoietic stemHematopoietic stemSelf-renewal capacityHuman hematopoiesisHuman cellsMultilineage differentiationHematopoietic cellsField of hematopoiesisLong-term hematopoietic stem cellsHuman CD34Progenitor cell biologyStem cellsProgenitor cellsHuman hematopoietic cellsHuman hematopoietic stem cellsHuman thrombopoietinHuman homologuePopulation of cellsCell biologyEnhanced self-renewal capacityFunctional analysisSecondary recipientsLymphoid lineageXenogeneic environment