Inhibiting Free Fatty Acid Transport to Improve CAR-T Cell Therapy of Relapsed B-Cell Acute Lymphoblastic Leukemia
Garcia C, Lyons K, Liu T, Iacobucci I, Novak A, Argabright A, Donnelly A, Grandvallet Contreras J, Geng H, Smith S, Zhou X, Müschen M, Dick J, Haines J, D'Alessandro A, Mullighan C, Phang T, Kohler M, Witkowski M. Inhibiting Free Fatty Acid Transport to Improve CAR-T Cell Therapy of Relapsed B-Cell Acute Lymphoblastic Leukemia. Blood 2024, 144: 1446-1446. DOI: 10.1182/blood-2024-201015.Peer-Reviewed Original ResearchB-cell acute lymphoblastic leukemiaB-ALL cell linesCAR-TCAR-T therapyB-ALL cellsAcute lymphoblastic leukemiaHuman B-ALL cell linesTP53-MUTLoss-of-function mutationsTP53 mutationsLymphoblastic leukemiaCD19-directed chimeric antigen receptor T cellsB-ALL diagnosisRelapsed B-ALLRelapsed B-cell acute lymphoblastic leukemiaRelapsed/refractory B-cell acute lymphoblastic leukemiaFree fatty acid transportB cell acute lymphoblastic leukemia cellsChimeric antigen receptor T cellsCD19 CAR-T therapyHigh-risk genetic featuresCAR-T cell therapyAssociated with chemotherapy resistanceResistant to conventional chemotherapyPediatric B-ALL patients