2022
Integrative genome-wide analysis reveals EIF3A as a key downstream regulator of translational repressor protein Musashi 2 (MSI2)
Karmakar S, Ramirez O, Paul KV, Gupta AK, Kumari V, Botti V, de los Mozos IR, Neuenkirchen N, Ross RJ, Karanicolas J, Neugebauer KM, Pillai MM. Integrative genome-wide analysis reveals EIF3A as a key downstream regulator of translational repressor protein Musashi 2 (MSI2). NAR Cancer 2022, 4: zcac015. PMID: 35528200, PMCID: PMC9070473, DOI: 10.1093/narcan/zcac015.Peer-Reviewed Original ResearchRNA binding proteinMusashi-2Functional targetIntegrative genome-wide analysisGenome-wide analysisIndividual-nucleotide resolutionAsymmetric cell divisionCell fate decisionsThousands of mRNAsKey downstream regulatorProtein Musashi-2Polysome profilingFate decisionsEukaryotic translation initiation factor 3aNucleotide resolutionCell divisionDirect RNATranslational inductionCancer stem cellsDownstream regulatorsUntranslated regionIndirect targetsBinding proteinDirect targetMere binding
2016
Integrative Analysis of RNA-Interactome and Translatome Reveal Functional Targets of MSI2 in Myeloid Leukemia
Ramirez O, Kesarwani A, Abhishek G, Minella A, Pillai M. Integrative Analysis of RNA-Interactome and Translatome Reveal Functional Targets of MSI2 in Myeloid Leukemia. Blood 2016, 128: 1881. DOI: 10.1182/blood.v128.22.1881.1881.Peer-Reviewed Original ResearchRNA binding proteinPolysome profilingCell cycle regulatorsTranscription factorsMusashi-2RNA interactomeTarget mRNAsFunctional targetAsymmetric cell divisionSpecific cellular functionsThousands of transcriptsDNA damage responseRBP-RNA complexesMinimal sequence motifSequence-specific fashionPrecise molecular mechanismsTranslational repressionTranslatome profilingCell fateTranslatome analysisCellular functionsSequence motifsDamage responseCell divisionNext-generation sequencing