2015
Regulation of actin polymerization by tropomodulin-3 controls megakaryocyte actin organization and platelet biogenesis
Sui Z, Nowak RB, Sanada C, Halene S, Krause DS, Fowler VM. Regulation of actin polymerization by tropomodulin-3 controls megakaryocyte actin organization and platelet biogenesis. Blood 2015, 126: 520-530. PMID: 25964668, PMCID: PMC4513252, DOI: 10.1182/blood-2014-09-601484.Peer-Reviewed Original ResearchMeSH KeywordsActin CytoskeletonAnimalsApoptosisBlood PlateletsBlotting, WesternCell MembraneCell ProliferationCells, CulturedCytoplasmEmbryo, MammalianFemaleFluorescent Antibody TechniqueHematopoiesisHemorrhageImmunoprecipitationMegakaryocytesMiceMice, KnockoutMicroscopy, ConfocalMicroscopy, Electron, TransmissionMicroscopy, FluorescencePloidiesPolymerizationTropomodulinConceptsPlatelet biogenesisDemarcation membrane systemF-actinTropomodulin-3Organelle distributionProplatelet formationActin polymerizationF-actin cappingF-actin organizationF-actin cytoskeletonWild-type megakaryocytesActin cytoskeletonActin organizationMK differentiationTmod isoformsLarge proplateletsBiogenesisContractile bundlesActin filamentsDMS formationBinds tropomyosinBud sizeMK numberConfocal microscopyCytoskeleton
2009
Fanconi Anemia Complementation Group FANCD2 Protein Serine 331 Phosphorylation Is Important for Fanconi Anemia Pathway Function and BRCA2 Interaction
Zhi G, Wilson JB, Chen X, Krause DS, Xiao Y, Jones NJ, Kupfer GM. Fanconi Anemia Complementation Group FANCD2 Protein Serine 331 Phosphorylation Is Important for Fanconi Anemia Pathway Function and BRCA2 Interaction. Cancer Research 2009, 69: 8775-8783. PMID: 19861535, PMCID: PMC5912675, DOI: 10.1158/0008-5472.can-09-2312.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBRCA2 ProteinCell LineCheckpoint Kinase 1DNA DamageFanconi AnemiaFanconi Anemia Complementation Group D2 ProteinFanconi Anemia Complementation Group ProteinsHumansImmunoblottingImmunoprecipitationMass SpectrometryPhosphorylationProtein KinasesSequence Homology, Amino AcidSerineSignal TransductionConceptsS-phase checkpoint kinaseFanconi anemia DNA repair pathwayFanconi anemia pathwayRegulatory phosphorylation eventsDNA repair pathwaysFANCD1/BRCA2Phosphomimetic mutationBRCA2 interactionsPhosphorylation eventsSerine 331Checkpoint kinaseCancer susceptibility syndromeComplementation groupsRepair pathwaysPathway functionFanconi anemiaBone marrow failurePhosphorylationDownstream playersVivo interactionS331Susceptibility syndromeMarrow failurePathwayMonoubiquitylation