2024
Genetic relations between type 1 diabetes, coronary artery disease and leukocyte counts.
Adebekun J, Nadig A, Saarah P, Asgari S, Kachuri L, Alagpulinsa DA. Genetic relations between type 1 diabetes, coronary artery disease and leukocyte counts. Diabetologia 2024 PMID: 39141130, DOI: 10.1007/s00125-024-06247-9.Peer-Reviewed Original ResearchAssociation of T-cell subtypes with macrophage-specific arterial infiltration in people with HIV
Schnittman S, Talathi R, Wilks M, Hedgire S, Lu M, Fourman L, Alagpulinsa D, Stockman S, White K, Wallis Z, Autissier P, Stanley T, Lee H, Honigberg M, El-Fakhri G, Williams K, Zanni M, Grinspoon S, Toribio M. Association of T-cell subtypes with macrophage-specific arterial infiltration in people with HIV. AIDS 2024, 38: 1940-1946. PMID: 38905489, DOI: 10.1097/qad.0000000000003967.Peer-Reviewed Original ResearchArterial infiltrationCardiovascular diseaseIncreased risk of cardiovascular diseaseHuman immunodeficiency virusT cell subtypesT lymphocyte subpopulationsRisk of cardiovascular diseaseSystemic monocyte activationCardiovascular disease riskImmunodeficiency virusMonocyte activationHIV statusIncreased riskRelevant to atherogenesisHIVInfiltrationGeneral populationPWHEvidence of interactionSubtypesDiseaseSubpopulationsAtherogenesis
2023
Short-term function and immune-protection of microencapsulated adult porcine islets with alginate incorporating CXCL12 in healthy and diabetic non-human primates without systemic immune suppression: A pilot study.
Sremac M, Luo H, Deng H, Parr MFE, Hutcheson J, Verde PS, Alagpulinsa DA, Kitzmann JM, Papas KK, Brauns T, Markmann JF, Lei J, Poznansky MC. Short-term function and immune-protection of microencapsulated adult porcine islets with alginate incorporating CXCL12 in healthy and diabetic non-human primates without systemic immune suppression: A pilot study. Xenotransplantation 2023, e12826. PMID: 37712342, DOI: 10.1111/xen.12826.Peer-Reviewed Original ResearchPlasma osteopontin relates to myocardial fibrosis and steatosis and to immune activation among women with HIV.
Robinson JA, Toribio M, Quinaglia T, Awadalla M, Talathi R, Durbin CG, Alhallak I, Alagpulinsa DA, Fourman LT, Suero-Abreu GA, Nelson MD, Stanley TL, Longenecker CT, Szczepaniak LS, Jerosch-Herold M, Neilan TG, Zanni MV, Burdo TH. Plasma osteopontin relates to myocardial fibrosis and steatosis and to immune activation among women with HIV. AIDS 2023, 37: 305-310. PMID: 36541642, DOI: 10.1097/QAD.0000000000003417.Peer-Reviewed Original Research
2022
Cardiac strain is lower among women with HIV in relation to monocyte activation.
Toribio M, Awadalla M, Drobni ZD, Quinaglia T, Wang M, Durbin CG, Alagpulinsa DA, Fourman LT, Suero-Abreu GA, Nelson MD, Stanley TL, Longenecker CT, Burdo TH, Neilan TG, Zanni MV. Cardiac strain is lower among women with HIV in relation to monocyte activation. PLoS One 2022, 17: e0279913. PMID: 36584183, DOI: 10.1371/journal.pone.0279913.Peer-Reviewed Original ResearchAdvances in understanding the molecular basis of clonal hematopoiesis.
Alagpulinsa DA, Toribio MP, Alhallak I, Shmookler Reis RJ. Advances in understanding the molecular basis of clonal hematopoiesis. Trends Mol Med 2022, 28: 360-377. PMID: 35341686, DOI: 10.1016/j.molmed.2022.03.002.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2021
Metabolomic and transcriptomic analyses of the anti-rheumatoid arthritis potential of xylopic acid in a bioinspired lipoprotein nanoformulation.
Alolga RN, Opoku-Damoah Y, Alagpulinsa DA, Huang FQ, Ma G, Chavez Leon MASC, Kudzai C, Yin X, Ding Y. Metabolomic and transcriptomic analyses of the anti-rheumatoid arthritis potential of xylopic acid in a bioinspired lipoprotein nanoformulation. Biomaterials 2021, 268: 120482. PMID: 33307367, DOI: 10.1016/j.biomaterials.2020.120482.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2020
Genomic Instability in Multiple Myeloma.
Alagpulinsa DA, Szalat RE, Poznansky MC, Shmookler Reis RJ. Genomic Instability in Multiple Myeloma. Trends Cancer 2020, 6: 858-873. PMID: 32487486, DOI: 10.1016/j.trecan.2020.05.006.Peer-Reviewed Original Research
2019
Amplification and overexpression of E2 ubiquitin conjugase UBE2T promotes homologous recombination in multiple myeloma.
Alagpulinsa D, Kumar S, Talluri S, Nanjappa P, Buon L, Chakraborty C, Samur M, Szalat R, Shammas M, Munshi N. Amplification and overexpression of E2 ubiquitin conjugase UBE2T promotes homologous recombination in multiple myeloma. Blood Advances 2019, 3: 3968-3972. PMID: 31805191, PMCID: PMC6963244, DOI: 10.1182/bloodadvances.2019000181.Peer-Reviewed Original ResearchAlginate-microencapsulation of human stem cell-derived β cells with CXCL12 prolongs their survival and function in immunocompetent mice without systemic immunosuppression.
Alagpulinsa DA, Cao JJL, Driscoll RK, Sîrbulescu RF, Penson MFE, Sremac M, Engquist EN, Brauns TA, Markmann JF, Melton DA, Poznansky MC. Alginate-microencapsulation of human stem cell-derived β cells with CXCL12 prolongs their survival and function in immunocompetent mice without systemic immunosuppression. Am J Transplant 2019, 19: 1930-1940. PMID: 30748094, DOI: 10.1111/ajt.15308.Peer-Reviewed Original ResearchHarnessing CXCL12 signaling to protect and preserve functional β-cell mass and for cell replacement in type 1 diabetes.
Alagpulinsa DA, Cao JJL, Sobell D, Poznansky MC. Harnessing CXCL12 signaling to protect and preserve functional β-cell mass and for cell replacement in type 1 diabetes. Pharmacol Ther 2019, 193: 63-74. PMID: 30149101, DOI: 10.1016/j.pharmthera.2018.08.011.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2016
A Cyclin-Dependent Kinase Inhibitor, Dinaciclib, Impairs Homologous Recombination and Sensitizes Multiple Myeloma Cells to PARP Inhibition.
Alagpulinsa DA, Ayyadevara S, Yaccoby S, Shmookler Reis RJ. A Cyclin-Dependent Kinase Inhibitor, Dinaciclib, Impairs Homologous Recombination and Sensitizes Multiple Myeloma Cells to PARP Inhibition. Mol Cancer Ther 2016, 15: 241-50. PMID: 26719576, DOI: 10.1158/1535-7163.MCT-15-0660.Peer-Reviewed Original Research
2015
A peptide nucleic acid targeting nuclear RAD51 sensitizes multiple myeloma cells to melphalan treatment.
Alagpulinsa DA, Yaccoby S, Ayyadevara S, Shmookler Reis RJ. A peptide nucleic acid targeting nuclear RAD51 sensitizes multiple myeloma cells to melphalan treatment. Cancer Biol Ther 2015, 16: 976-86. PMID: 25996477, DOI: 10.1080/15384047.2015.1040951.Peer-Reviewed Original Research
2014
A Small-Molecule Inhibitor of RAD51 Reduces Homologous Recombination and Sensitizes Multiple Myeloma Cells to Doxorubicin.
Alagpulinsa DA, Ayyadevara S, Shmookler Reis RJ. A Small-Molecule Inhibitor of RAD51 Reduces Homologous Recombination and Sensitizes Multiple Myeloma Cells to Doxorubicin. Front Oncol 2014, 4: 289. PMID: 25401086, DOI: 10.3389/fonc.2014.00289.Peer-Reviewed Original Research