Antigen modulation as a potential mechanism of anti-KEL immunoprophylaxis in mice
Liu J, Santhanakrishnan M, Natarajan P, Gibb DR, Eisenbarth SC, Tormey CA, Siddon AJ, Stowell SR, Branch DR, Hendrickson JE. Antigen modulation as a potential mechanism of anti-KEL immunoprophylaxis in mice. Blood 2016, 128: 3159-3168. PMID: 27688803, PMCID: PMC5201095, DOI: 10.1182/blood-2016-06-724732.Peer-Reviewed Original ResearchConceptsMechanism of actionKO miceRed blood cell alloimmunizationGlycoprotein antigenMurine RBCsHuman KEL glycoproteinRh immune globulinSingle knockout miceWild-type recipientsImmunoprophylaxis programKO recipientsPrevent alloimmunizationImmune globulinSerious complicationsAntigen modulationMurine modelImmunoprophylaxisFcγ receptorsKEL antigenAlloimmunizationFlow cytometryRapid clearanceWestern blotMiceAntigenCD8+ T cells mediate antibody-independent platelet clearance in mice
Arthur CM, Patel SR, Sullivan HC, Winkler AM, Tormey CA, Hendrickson JE, Stowell SR. CD8+ T cells mediate antibody-independent platelet clearance in mice. Blood 2016, 127: 1823-1827. PMID: 26787734, PMCID: PMC4825415, DOI: 10.1182/blood-2015-10-673426.Peer-Reviewed Original ResearchConceptsPlatelet clearancePlatelet removalImportant therapeutic interventionPlatelet transfusionsNonimmune mechanismsT cellsTherapeutic outcomesAlloantibodiesTherapeutic interventionsAppropriate managementTransfusionClearanceSole mediatorPatientsVariety of mechanismsComplete absenceNumerous studiesCD8Clear mechanismCellsAbsenceMiceIndividualsPrevention