2003
Reversibility of severe metabolic stress in stored platelets after in vitro plasma rescue or in vivo transfusion: restoration of secretory function and maintenance of platelet survival
Rinder HM, Snyder EL, Tracey JB, Dincecco D, Wang C, Baril L, Rinder CS, Smith BR. Reversibility of severe metabolic stress in stored platelets after in vitro plasma rescue or in vivo transfusion: restoration of secretory function and maintenance of platelet survival. Transfusion 2003, 43: 1230-1237. PMID: 12919425, DOI: 10.1046/j.1537-2995.2003.00484.x.Peer-Reviewed Original ResearchConceptsGlycoprotein IIb/IIIaAlpha-granule releaseAdverse metabolic conditionsIIb/IIIaPlatelet recoveryPlatelet concentratesMetabolic conditionsVivo platelet recoveryPlatelet secretory responseSevere metabolic stressOsmotic recoveryAgonist-induced bindingAutologous transfusionTransient derangementSecretory responseFunctional derangementFunctional abnormalitiesMembrane phosphatidylserine exposureMetabolic rescueNormal volunteersPlatelet survivalPosttransfusion recoveryPlatelet aggregationImproved functionSecretory function
2002
Reticulated platelets predict platelet count recovery following chemotherapy
Wang C, Smith BR, Ault KA, Rinder HM. Reticulated platelets predict platelet count recovery following chemotherapy. Transfusion 2002, 42: 368-374. PMID: 11961244, DOI: 10.1046/j.1537-2995.2002.00040.x.Peer-Reviewed Original ResearchConceptsPlatelet count recoveryPercentage of RPProphylactic platelet transfusionsCount recoveryPlatelet transfusionsPlatelet recoveryStress thrombopoiesisPlatelet count increaseIdiopathic thrombocytopenic purpuraPlatelet count nadirsChemotherapy-induced thrombocytopeniaNegative predictive valueEvaluable patientsMarrow suppressionThrombocytopenic purpuraChemotherapy patientsThrombocytopenia patientsLower percentagePatientsPredictive valueReproducible indexThrombocytopeniaTransfusionChemotherapyIncreased percentage