2003
Reversibility of severe metabolic stress in stored platelets after in vitro plasma rescue or in vivo transfusion: restoration of secretory function and maintenance of platelet survival
Rinder HM, Snyder EL, Tracey JB, Dincecco D, Wang C, Baril L, Rinder CS, Smith BR. Reversibility of severe metabolic stress in stored platelets after in vitro plasma rescue or in vivo transfusion: restoration of secretory function and maintenance of platelet survival. Transfusion 2003, 43: 1230-1237. PMID: 12919425, DOI: 10.1046/j.1537-2995.2003.00484.x.Peer-Reviewed Original ResearchConceptsGlycoprotein IIb/IIIaAlpha-granule releaseAdverse metabolic conditionsIIb/IIIaPlatelet recoveryPlatelet concentratesMetabolic conditionsVivo platelet recoveryPlatelet secretory responseSevere metabolic stressOsmotic recoveryAgonist-induced bindingAutologous transfusionTransient derangementSecretory responseFunctional derangementFunctional abnormalitiesMembrane phosphatidylserine exposureMetabolic rescueNormal volunteersPlatelet survivalPosttransfusion recoveryPlatelet aggregationImproved functionSecretory function
1994
In vitro characteristics of white cell‐reduced single‐unit platelet concentrates stored in syringes
Pisciotto PT, Snyder EL, Snyder JA, Frattaroli S, Hopfer SM, Rinder HM, Smith BR. In vitro characteristics of white cell‐reduced single‐unit platelet concentrates stored in syringes. Transfusion 1994, 34: 407-411. PMID: 8191565, DOI: 10.1046/j.1537-2995.1994.34594249052.x.Peer-Reviewed Original ResearchConceptsWBC filtrationP-selectin positivityPremature infantsDrug Administration requirementsPlatelet functionPlatelet activationPlatelet lossStudy designWhite cellsAdverse effectsPlatelet concentratesLactate productionTransfusionDegrees CVitro characteristicsAdministration requirementsSingle unitPlatelet propertiesLog10 reductionHoursSyringesConsumption of glucoseInfantsWBC
1991
Storage of platelet concentrates after high‐dose ultraviolet B irradiation
Snyder EL, Beardsley DS, Smith BR, Horne W, Johnson R, Wooten T, Napychank PA, Male P, Buchholz DH. Storage of platelet concentrates after high‐dose ultraviolet B irradiation. Transfusion 1991, 31: 491-496. PMID: 1853440, DOI: 10.1046/j.1537-2995.1991.31691306243.x.Peer-Reviewed Original ResearchConceptsUltraviolet B irradiationPlatelet concentratesUVB irradiationB irradiationWhite cell countGPIIb/IIIaHLA alloimmunizationPlatelet countBeta-thromboglobulinClinical trialsHours of storageUVB doseCell countBlood centersMembrane glycoprotein IbLactate dehydrogenaseSignificant decreaseControl platelet concentratesMorphology scorePlatelet deteriorationPlatelet proteinsDoseGlycoprotein IbOsmotic recoveryHours