Welcome to the Levine Research Group at the Yale School of Medicine (LRG@YSM).

The LRG@YSM seeks to understand and intervene in human degenerative diseases using a wide variety of theoretical and experimental techniques. In particular, we work to understand protein aggregation diseases from a biophysical perspective. Many of these conditions involve a toxic accumulation of amyloid proteins and plaques over the lifecourse, leading to degenerative dysfunction and death. By combining molecular models of protein folding and aggregation with solution biophysics techniques, we can deduce and modify thermodynamic landscapes that are distinctly pathological in order to mitigate human diseases. For more information, please visit our research interests and publications pages.