2024
Long‐Term Mortality Predictors Using a Machine‐Learning Approach in Patients With Chronic Limb‐Threatening Ischemia After Peripheral Vascular Intervention
Callegari S, Romain G, Cleman J, Scierka L, Jacque F, Smolderen K, Mena‐Hurtado C. Long‐Term Mortality Predictors Using a Machine‐Learning Approach in Patients With Chronic Limb‐Threatening Ischemia After Peripheral Vascular Intervention. Journal Of The American Heart Association 2024, 13: e034477. PMID: 38761075, PMCID: PMC11179837, DOI: 10.1161/jaha.124.034477.Peer-Reviewed Original ResearchConceptsChronic limb-threatening ischemiaPeripheral vascular interventionsHealth careLimb-threatening ischemiaMortality predictorsLong-term mortality riskMultidimensional risk factorsBody mass indexLong-term mortality predictorsImprove individualized careVascular interventionsIndividualized careAssisted careBiopsychosocial modelMortality riskCareMass indexRisk factorsMedical comorbiditiesRisk profileInterventionMortality rateChronic kidney diseaseMortalityPredictive variables
2023
Disparities in Diagnosis, Treatment, and Outcomes of Peripheral Artery Disease JACC Scientific Statement
McDermott M, Ho K, Alabi O, Criqui M, Goodney P, Hamburg N, McNeal D, Pollak A, Smolderen K, Bonaca M. Disparities in Diagnosis, Treatment, and Outcomes of Peripheral Artery Disease JACC Scientific Statement. Journal Of The American College Of Cardiology 2023, 82: 2312-2328. PMID: 38057074, DOI: 10.1016/j.jacc.2023.09.830.Peer-Reviewed Original ResearchConceptsPeripheral arterial diseaseRate of amputationAmputation ratePeripheral arterial disease prevalencePrevalence of peripheral arterial diseaseLower extremity peripheral arterial diseasePeripheral arterial disease outcomesHealth policy changesCulturally appropriate messagesHigher amputation rateOptimal medical careHealth carePatient educationDisparity eliminationMobility lossSocioeconomic statusClinician educationMedical careImprove accessLower extremity revascularizationUnited StatesAtypical symptomsOlder ageDisparitiesAmputationLongitudinal Pathways Between Physical Activity, Depression, and Perceived Stress in Peripheral Artery Disease.
Yazgan I, Bartlett V, Romain G, Cleman J, Petersen-Crair P, Spertus J, Hardt M, Mena-Hurtado C, Smolderen K. Longitudinal Pathways Between Physical Activity, Depression, and Perceived Stress in Peripheral Artery Disease. Circulation Cardiovascular Quality And Outcomes 2023, 16: 544-553. PMID: 37470195, PMCID: PMC10561081, DOI: 10.1161/circoutcomes.122.009840.Peer-Reviewed Original ResearchConceptsPhysical activityPAD diagnosisDepressive symptomsLower physical activity scoresPerceived stressVascular specialty clinicsPeripheral artery diseasePhysical activity scoreSignificant depressive symptomsPatient Health QuestionnaireBehavioral health approachesSubsequent depressive symptomsINTERHEART studySymptomatic PADCardiovascular eventsPAD symptomsArtery diseaseInitial presentationActivity scoreSpecialty clinicHealth QuestionnairePatient's abilityTreatment goalsPAD managementPerceived Stress ScaleComparison of lower extremity bypass and peripheral vascular intervention for chronic limb-threatening ischemia in the Medicare-linked Vascular Quality Initiative
Cleman J, Romain G, Grubman S, Guzman R, Smolderen K, Mena-Hurtado C. Comparison of lower extremity bypass and peripheral vascular intervention for chronic limb-threatening ischemia in the Medicare-linked Vascular Quality Initiative. Journal Of Vascular Surgery 2023, 78: 745-753.e6. PMID: 37207790, PMCID: PMC10964324, DOI: 10.1016/j.jvs.2023.05.015.Peer-Reviewed Original ResearchConceptsChronic limb-threatening ischemiaLower extremity bypassPeripheral vascular interventionsVascular Quality InitiativeLimb-threatening ischemiaCause mortalityRisk of deathExtremity bypassVascular interventionsQuality InitiativeCox proportional hazards regressionKaplan-Meier survival curvesProportional hazards regressionOverall mean ageLogistic regression modelsComparative effectiveness researchKnee poplitealMedicare registryInfrapopliteal arteriesHazards regressionMean ageThirty-dayHispanic ethnicityOutcome dataTreatment groupsLower extremity symptoms and ankle–brachial index screening as predictors of cardiovascular outcomes in Black adults
Lee M, Smolderen K, Ionescu C, Hillegass W, Romain G, Mena-Hurtado C. Lower extremity symptoms and ankle–brachial index screening as predictors of cardiovascular outcomes in Black adults. Vascular Medicine 2023, 28: 197-204. PMID: 37293738, DOI: 10.1177/1358863x231151729.Peer-Reviewed Original ResearchConceptsPeripheral artery diseaseAbnormal ABILower extremity symptomsNormal ABILeg symptomsHigh riskBlack adultsExtremity symptomsStepwise Cox proportional hazards modelKaplan-Meier survival curvesCox proportional hazards modelAnkle-brachial indexFramingham risk factorsJackson Heart StudyProportional hazards modelCardiovascular outcomesCause mortalityArtery diseaseAsymptomatic diseaseAdverse outcomesMean ageSymptom assessmentAsymptomatic participantsRisk factorsSymptomatic participantsThe use of evidence-based medical therapy in patients with critical limb-threatening ischaemia.
Bager L, Petersen J, Havers-Borgersen E, Resch T, Smolderen K, Mena-Hurtado C, Eiberg J, Køber L, Fosbøl E. The use of evidence-based medical therapy in patients with critical limb-threatening ischaemia. European Journal Of Preventive Cardiology 2023, 30: 1092-1100. PMID: 36708037, DOI: 10.1093/eurjpc/zwad022.Peer-Reviewed Original ResearchConceptsEvidence-based medical therapyARB/ACEILimb-threatening ischaemiaMyocardial infarctionMedical therapyHistory of MIHigh-risk patientsFirst-time hospitalizationUnadjusted odds ratioYears of ageMore comorbiditiesPatients 40Hazard ratioDanish registriesOverall mortalityAdjusted analysisAdverse prognosisOdds ratioPractice patternsPatientsMortality rateACEIIschaemiaTherapyMortality
2022
Derivation and validation of a predictive model for chronic stress in patients with cardiovascular disease
Malik AO, Jones PG, Mena-Hurtado C, Burg MM, Shishehbor MH, Hejjaji V, Tran A, Spertus JA, Smolderen KG. Derivation and validation of a predictive model for chronic stress in patients with cardiovascular disease. PLOS ONE 2022, 17: e0275729. PMID: 36256655, PMCID: PMC9578618, DOI: 10.1371/journal.pone.0275729.Peer-Reviewed Original ResearchConceptsPeripheral artery diseaseCardiovascular diseaseChronic stressWorse outcomesSymptomatic peripheral artery diseaseMyocardial Infarction RegistryLogistic regression modelsPAD patientsProspective registryCurrent smokingArtery diseaseClinical factorsDerivation cohortValidation cohortC-statisticFemale sexPerceived Stress ScalePatientsEconomic burdenMedical careInstrument scoresSocioeconomic statusPotential targetDiseasePSS-4 scoresThe association of depression with mortality and major adverse limb event outcomes in patients with peripheral artery disease: A systematic review and meta-analysis
Scierka LE, Mena-Hurtado C, Ahmed ZV, Yousef S, Arham A, Grimshaw AA, Harris KM, Burg M, Vriens PW, Heyligers J, Lee M, Yazgan I, Smolderen KG. The association of depression with mortality and major adverse limb event outcomes in patients with peripheral artery disease: A systematic review and meta-analysis. Journal Of Affective Disorders 2022, 320: 169-177. PMID: 36179780, DOI: 10.1016/j.jad.2022.09.098.Peer-Reviewed Original ResearchConceptsMajor adverse limb eventsPeripheral artery diseaseAssociation of depressionCause mortalityArtery diseaseDepressive symptomsSystematic reviewAdverse limb eventsAdverse prognostic outcomeCoronary artery diseaseRisk of biasImportant comorbidityPoor outcomeAdverse outcomesPrognostic outcomesPooled resultsRisk factorsObservational studyTreatment statusLimb eventsDepression severityPatientsLarger sample sizeMortalityRisk estimatesReal‐world VASCADE closure device versus manual compression use and outcomes in patients with severe common femoral artery disease
Nagpal S, Scierka LE, Castro‐Dominguez Y, Kansal D, Kunnirickal S, Hussain Y, Love K, Aboian E, Smolderen KG, Mena‐Hurtado C. Real‐world VASCADE closure device versus manual compression use and outcomes in patients with severe common femoral artery disease. Catheterization And Cardiovascular Interventions 2022, 100: 776-784. PMID: 36129818, DOI: 10.1002/ccd.30405.Peer-Reviewed Original ResearchConceptsPeripheral vascular interventionsManual compressionClosure deviceCommon femoral artery diseaseVascular Quality Initiative databaseFemoral artery diseasePropensity-matched cohortPseudoaneurysm rateRetroperitoneal bleedingArtery diseaseRetrospective reviewMean ageBaseline variablesInstitutional databaseNonsignificant reductionNonsignificant decreaseVascular interventionsMortality ratePatientsCompression useCollagen plugDiseaseInitiative databaseProcedural metricsDevice useA Narrative Review of the Association Between Depression and Heart Disease Among Women: Prevalence, Mechanisms of Action, and Treatment
Rome D, Sales A, Leeds R, Usseglio J, Cornelius T, Monk C, Smolderen KG, Moise N. A Narrative Review of the Association Between Depression and Heart Disease Among Women: Prevalence, Mechanisms of Action, and Treatment. Current Atherosclerosis Reports 2022, 24: 709-720. PMID: 35751731, PMCID: PMC9398966, DOI: 10.1007/s11883-022-01048-0.Peer-Reviewed Original ResearchConceptsCoronary heart diseaseCardiovascular diseaseMechanism of actionHeart diseaseNarrative reviewManagement of depressionPrevalence of depressionRecent FindingsWomenCardiovascular outcomesAutonomic factorsDepression treatmentComorbid depressionTreatment inertiaGreater prevalenceTherapeutic targetPrevalenceStrong associationWomenDepressionDiseaseGreater mortalityTreatment effectsAssociationMenTreatmentVariability in 30-day major amputation rates following endovascular peripheral vascular intervention for critical limb ischemia
Provance JB, Spertus JA, Jones PG, Hoffman MA, Bunte MC, Vogel TR, Mena-Hurtado C, Smolderen KG. Variability in 30-day major amputation rates following endovascular peripheral vascular intervention for critical limb ischemia. Vascular Medicine 2022, 27: 350-357. PMID: 35603755, DOI: 10.1177/1358863x221098097.Peer-Reviewed Original ResearchConceptsPeripheral vascular interventionsCritical limb ischemiaMedian risk ratioEndovascular peripheral vascular interventionsMajor amputation ratePatient-level factorsAmputation ratePVI procedureLimb ischemiaRisk ratioVascular interventionsNational electronic health record databaseElectronic health record databasePredictors of amputationRate of amputationMixed effects Poisson regression modelHealth record databaseEffects Poisson regression modelPoisson regression modelsCLI carePrevious amputationClinical factorsCLI treatmentBlack raceDiagnosis codesOne-Year Health Status Outcomes Following Early Invasive and Noninvasive Treatment in Symptomatic Peripheral Artery Disease
Angraal S, Hejjaji V, Tang Y, Gosch KL, Patel MR, Heyligers J, White CJ, Nolthenius R, Mena-Hurtado C, Aronow HD, Moneta GL, Fitridge R, Soukas PA, Abbott JD, Secemsky EA, Spertus JA, Smolderen KG. One-Year Health Status Outcomes Following Early Invasive and Noninvasive Treatment in Symptomatic Peripheral Artery Disease. Circulation Cardiovascular Interventions 2022, 15: e011506. PMID: 35579010, PMCID: PMC11299756, DOI: 10.1161/circinterventions.121.011506.Peer-Reviewed Original ResearchConceptsHealth status outcomesPropensity-matched sampleEarly invasiveHealth statusEarly revascularizationStatus outcomesSymptomatic peripheral artery diseaseDisease-specific health statusNoninvasive management strategiesPeripheral Artery QuestionnaireTreatment-resistant symptomsEarly invasive managementPeripheral artery diseaseBaseline health statusEarly invasive treatmentHealth status trajectoriesHealth status improvementReal-world evidencePORTRAIT registryArtery diseaseInvasive managementNoninvasive managementPatient preferencesInvasive treatmentLifestyle changesThe Nevada peripheral artery disease screening effort in a Medicare Advantage population and subsequent mortality and major adverse cardiovascular event risk
Smolderen KG, Heath K, Scherr T, Bauzon SR, Howell AN, Mena-Hurtado C. The Nevada peripheral artery disease screening effort in a Medicare Advantage population and subsequent mortality and major adverse cardiovascular event risk. Journal Of Vascular Surgery 2022, 75: 2054-2064.e3. PMID: 35181520, DOI: 10.1016/j.jvs.2022.01.134.Peer-Reviewed Original ResearchConceptsMajor adverse cardiovascular eventsPeripheral artery diseaseUnadjusted hazard ratioLower extremity peripheral artery diseaseHazard ratioMedicare Advantage beneficiariesCause mortalityElectronic medical recordsArtery diseaseMajor adverse cardiovascular event riskAdverse cardiovascular eventsAtherosclerotic risk factorsMedicare Advantage populationCardiovascular event riskAnnual health assessmentPrimary care providersPatients' electronic medical recordsRisk of mortalityScreening resultsPositive screening resultsMACE ratePAD screeningCardiovascular eventsMultivariable adjustmentScreening statusAssociation of Disease‐Specific Health Status With Long‐Term Survival in Peripheral Artery Disease
Tran AT, Spertus JA, Mena‐Hurtado C, Jones PG, Aronow HD, Safley DM, Malik AO, Peri‐Okonny P, Shishehbor MH, Labrosciano C, Smolderen KG. Association of Disease‐Specific Health Status With Long‐Term Survival in Peripheral Artery Disease. Journal Of The American Heart Association 2022, 11: e022232. PMID: 35132874, PMCID: PMC9245831, DOI: 10.1161/jaha.121.022232.Peer-Reviewed Original ResearchConceptsPeripheral artery diseasePAD-specific health statusHealth statusPAD symptomsArtery diseaseHierarchical Cox regression modelsDisease-specific health statusLong-term mortality riskTime of diagnosisCox regression modelLong-term survivalPORTRAIT registryCardiovascular morbidityCause mortalityResults PatientsKaplan-MeierMortality riskUnadjusted modelsSummary scoresUS sitesPatientsMortalityBaselineSymptomsDisease
2021
Patient representativeness of a peripheral artery disease cohort in a randomized control trial versus a real-world cohort: The CLEVER trial versus the PORTRAIT registry
Scierka LE, Jelani QU, Smolderen KG, Gosch K, Spertus JA, Mena-Hurtado C, Jones P, Dreyer RP. Patient representativeness of a peripheral artery disease cohort in a randomized control trial versus a real-world cohort: The CLEVER trial versus the PORTRAIT registry. Contemporary Clinical Trials 2021, 112: 106624. PMID: 34793986, DOI: 10.1016/j.cct.2021.106624.Peer-Reviewed Original ResearchConceptsOptimal medical therapyPeripheral artery diseasePatient characteristicsBaseline patient characteristicsPAD cohortPAD populationPORTRAIT registryExercise therapyPAD patientsPAD symptomsArtery diseaseFinal cohortMedical therapyProspective studyBurdensome diseaseControl trialHealth statusPatientsTherapyCohortCLEVER studyDiseaseMulticenterRevascularizationRCTsIncreasing Prevalence of Critical Limb Ischemia Hospitalizations With Distinct Mental Health Burden Among Younger Adults
Harris KM, Mena-Hurtado C, Arham A, Burg MM, Freedland KE, Sinha R, Alabi O, Smolderen KG. Increasing Prevalence of Critical Limb Ischemia Hospitalizations With Distinct Mental Health Burden Among Younger Adults. Journal Of The American College Of Cardiology 2021, 78: 2126-2128. PMID: 34794693, DOI: 10.1016/j.jacc.2021.09.025.Peer-Reviewed Original ResearchGuideline-Directed Medical Therapy in Patients with Chronic Kidney Disease Undergoing Peripheral Vascular Intervention
Jelani QU, Llanos-Chea F, Bogra P, Trejo-Paredes C, Huang J, Provance JB, Turner J, Anantha-Narayanan M, Sheikh AB, Smolderen KG, Mena-Hurtado C. Guideline-Directed Medical Therapy in Patients with Chronic Kidney Disease Undergoing Peripheral Vascular Intervention. American Journal Of Nephrology 2021, 52: 845-853. PMID: 34706363, DOI: 10.1159/000519484.Peer-Reviewed Original ResearchConceptsComorbid chronic kidney diseaseGuideline-directed medical therapyPeripheral vascular interventionsCritical limb ischemiaMedian odds ratioMedical therapyPrescription ratesVascular interventionsHigh riskUse of GDMTAdjusted median odds ratioVascular Quality Initiative databaseAngiotensin-converting enzyme inhibitorAngiotensin receptor blockersChronic kidney diseaseLower prescription ratesPoor clinical outcomeCKD groupCKD statusAntiplatelet therapyReceptor blockersLimb ischemiaLimb outcomesClinical outcomesMedical managementPeripheral Artery Disease and COVID-19 Outcomes: Insights from the Yale DOM-CovX Registry
Smolderen KG, Lee M, Arora T, Simonov M, Mena-Hurtado C. Peripheral Artery Disease and COVID-19 Outcomes: Insights from the Yale DOM-CovX Registry. Current Problems In Cardiology 2021, 47: 101007. PMID: 34627824, PMCID: PMC8496926, DOI: 10.1016/j.cpcardiol.2021.101007.Peer-Reviewed Original ResearchConceptsPeripheral arterial diseaseSARS-CoV-2Myocardial infarctionMajor adverse cardiovascular eventsAdverse cardiovascular eventsPeripheral artery diseaseOdds of mortalityCOVID-19 infectionCOVID-19 outcomesLogistic regression modelsCardiovascular eventsArtery diseaseArterial diseaseMean ageRisk factorsWorse outcomesPatientsMinority raceMortalityRegistryStrokeDiseaseMACERegression modelsOutcomesAssociation of sleep apnea with outcomes in peripheral artery disease: Insights from the PORTRAIT study
Jelani QU, Mena-Hurtado C, Gosch K, Mohammed M, Labrosciano C, Regan C, Scierka LE, Spertus JA, Nagpal S, Smolderen KG. Association of sleep apnea with outcomes in peripheral artery disease: Insights from the PORTRAIT study. PLOS ONE 2021, 16: e0256933. PMID: 34506511, PMCID: PMC8432750, DOI: 10.1371/journal.pone.0256933.Peer-Reviewed Original ResearchConceptsPeripheral artery diseasePeripheral Artery QuestionnaireSleep apneaHealth statusArtery diseaseSummary scoresDisease-specific Peripheral Artery QuestionnaireFive-year survival curvesHigh ankle-brachial indexPAQ summary scoreVascular specialty clinicsAnkle-brachial indexLog-rank testSleep apnea statusHealth status outcomesWorse health statusQuality of lifeBetter health statusCause mortalityMultivariable adjustmentPAD symptomsCoronary diseasePeripheral interventionsUS patientsMean ageTELEHEALTH CARE BEFORE AND DURING COVID-19: TRENDS AND QUALITY IN A LARGE HEALTH SYSTEM
Luna P, Lee M, DeLucia N, London Y, Hoffman P, Burg M, Harris K, Spatz E, Hurtado C, Smolderen K. TELEHEALTH CARE BEFORE AND DURING COVID-19: TRENDS AND QUALITY IN A LARGE HEALTH SYSTEM. Journal Of The American College Of Cardiology 2021, 77: 3229. PMID: 34167649, PMCID: PMC8091376, DOI: 10.1016/s0735-1097(21)04583-6.Peer-Reviewed Original Research