2023
Neonatal loss of FGFR2 in astroglial cells affects locomotion, sociability, working memory, and glia-neuron interactions in mice
Stevens H, Scuderi S, Collica S, Tomasi S, Horvath T, Vaccarino F. Neonatal loss of FGFR2 in astroglial cells affects locomotion, sociability, working memory, and glia-neuron interactions in mice. Translational Psychiatry 2023, 13: 89. PMID: 36906620, PMCID: PMC10008554, DOI: 10.1038/s41398-023-02372-y.Peer-Reviewed Original ResearchConceptsFibroblast growth factor receptor 2Anxiety-like behaviorAttention deficit hyperactivity disorderAstroglial cellsGrowth factor receptor 2Reduced anxiety-like behaviorGlia-neuron interactionsAstroglial cell functionEarly postnatal periodFactor receptor 2Early postnatal lossPostnatal mouse brainWeeks of ageDeficit hyperactivity disorderGlial cellsGlutamine synthetase expressionBehavioral deficitsPostnatal periodReceptor 2Floxed miceHGFAP-CreMouse brainNeonatal lossPostnatal astrogliaPostnatal loss
2014
Alternative Splicing Generates Different Parkin Protein Isoforms: Evidences in Human, Rat, and Mouse Brain
Scuderi S, La Cognata V, Drago F, Cavallaro S, D′Agata V. Alternative Splicing Generates Different Parkin Protein Isoforms: Evidences in Human, Rat, and Mouse Brain. BioMed Research International 2014, 2014: 690796. PMID: 25136611, PMCID: PMC4124806, DOI: 10.1155/2014/690796.Peer-Reviewed Original ResearchConceptsExtensive alternative splicingParkinson protein 2Parkin isoformsAutosomal recessive early-onset Parkinson's diseaseTranscriptomic diversificationRecessive early-onset Parkinson's diseaseEncoded proteinsAlternative splicingPrimary transcriptGene mutationsExpression patternsGene transcriptsHuman pathologiesSplice variantsParkin deficiencyAmino acidsProtein 2Early-onset Parkinson's diseaseSporadic Parkinson's diseaseIsoformsElectrophoretic mobilityOnset Parkinson's diseaseTranscriptsProteinJuvenile Parkinson's diseaseNAP Reduces Murine Microvascular Endothelial Cells Proliferation Induced by Hyperglycemia
D’Amico A, Scuderi S, Maugeri G, Cavallaro S, Drago F, D’Agata V. NAP Reduces Murine Microvascular Endothelial Cells Proliferation Induced by Hyperglycemia. Journal Of Molecular Neuroscience 2014, 54: 405-413. PMID: 24874579, DOI: 10.1007/s12031-014-0335-2.Peer-Reviewed Original ResearchConceptsProtein kinase/extracellular signal-regulated protein kinaseExtracellular signal-regulated protein kinaseMitogen-activated protein kinase/extracellular signal-regulated protein kinaseSignal-regulated protein kinaseKinase/Akt pathwayEndothelial cell proliferationPhosphatidylinositol-3-kinase/Akt pathwayCell proliferationProtein expression analysisProtein kinaseExpression analysisBiological roleAkt pathwayPhosphorylation levelsTime-dependent mannerHigh glucoseMurine microvascular endothelial cellsMicrovascular endothelial cell proliferationMicrovascular endothelial cellsEndothelial cellsProliferationMTT assayCells
2013
Increased Hippocampal CREB Phosphorylation in Dopamine D3 Receptor Knockout Mice Following Passive Avoidance Conditioning
D’Amico A, Scuderi S, Leggio G, Castorina A, Drago F, D’Agata V. Increased Hippocampal CREB Phosphorylation in Dopamine D3 Receptor Knockout Mice Following Passive Avoidance Conditioning. Neurochemical Research 2013, 38: 2516-2523. PMID: 24100927, DOI: 10.1007/s11064-013-1164-3.Peer-Reviewed Original ResearchConceptsMitogen-activated protein kinaseCAMP response element-binding proteinNuclear transcription factor cAMP response element-binding proteinTranscription factor cAMP response element-binding proteinExtracellular signal-regulated kinase 1/2C-Jun N-terminal kinaseCREB phosphorylationSignal-regulated kinase 1/2Response element-binding proteinElement-binding proteinProtein kinaseDe novo synthesisKinase 1/2ERK signalingAkt activationBinding proteinPhosphorylationPhosphorylation levelsP38 phosphorylationGenetic backgroundKnockout mice displayNovo synthesisKinaseSynaptic functionAktDopamine D3 receptor deletion increases tissue plasminogen activator (tPA) activity in prefrontal cortex and hippocampus
Castorina A, D’Amico A, Scuderi S, Leggio G, Drago F, D’Agata V. Dopamine D3 receptor deletion increases tissue plasminogen activator (tPA) activity in prefrontal cortex and hippocampus. Neuroscience 2013, 250: 546-556. PMID: 23906635, DOI: 10.1016/j.neuroscience.2013.07.053.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlotting, WesternBrain-Derived Neurotrophic FactorCyclic AMP Response Element-Binding ProteinDopamine and cAMP-Regulated Phosphoprotein 32FibrinolysinGlycogen Synthase Kinase 3Glycogen Synthase Kinase 3 betaHippocampusImmunohistochemistryLearningMaleMemoryMiceMice, KnockoutOncogene Protein v-aktPhosphorylationPrefrontal CortexReal-Time Polymerase Chain ReactionReceptors, Dopamine D3RNA, MessengerRNA, Ribosomal, 18STissue Plasminogen Activator