2021
Cell-to-Cell Adhesion and Neurogenesis in Human Cortical Development: A Study Comparing 2D Monolayers with 3D Organoid Cultures
Scuderi S, Altobelli GG, Cimini V, Coppola G, Vaccarino FM. Cell-to-Cell Adhesion and Neurogenesis in Human Cortical Development: A Study Comparing 2D Monolayers with 3D Organoid Cultures. Stem Cell Reports 2021, 16: 264-280. PMID: 33513360, PMCID: PMC7878838, DOI: 10.1016/j.stemcr.2020.12.019.Peer-Reviewed Original Research
2015
Different Retinal Expression Patterns of IL-1α, IL-1β, and Their Receptors in a Rat Model of Type 1 STZ-Induced Diabetes
Scuderi S, D’amico A, Federico C, Saccone S, Magro G, Bucolo C, Drago F, D’Agata V. Different Retinal Expression Patterns of IL-1α, IL-1β, and Their Receptors in a Rat Model of Type 1 STZ-Induced Diabetes. Journal Of Molecular Neuroscience 2015, 56: 431-439. PMID: 25676032, DOI: 10.1007/s12031-015-0505-x.Peer-Reviewed Original ResearchConceptsIL-1 family membersDiabetic retinopathyIL-1αRetinal layersIL-1raIL-1βIL-1RIInvolvement of inflammationGanglion cell layerNew pharmacological approachesRetinal expression patternType 1 diabetesEffects of hyperglycemiaReceptor IL-1RIFamily membersCommon complicationDiabetic patientsDiabetic ratsProinflammatory cytokinesInflammatory processInterleukin-1βIntraperitoneal injectionRat modelInner plexiformIL-1RII
2014
Davunetide (NAP) Protects the Retina Against Early Diabetic Injury by Reducing Apoptotic Death
Scuderi S, D’Amico A, Castorina A, Federico C, Marrazzo G, Drago F, Bucolo C, D’Agata V. Davunetide (NAP) Protects the Retina Against Early Diabetic Injury by Reducing Apoptotic Death. Journal Of Molecular Neuroscience 2014, 54: 395-404. PMID: 24488575, DOI: 10.1007/s12031-014-0244-4.Peer-Reviewed Original ResearchConceptsNAP treatmentRetinas of STZSingle intraocular injectionCaspase-3 expression levelsRetinal degenerative diseasesMAPK/ERK pathwayPhosphatidylinositol-3-kinase/Akt pathwayMitogen-activated protein kinase/extracellular signal-regulated protein kinaseDiabetes inductionDiabetic injuryDiabetic retinaSTZ injectionNeuroprotective effectsDiabetic modelIntraocular injectionPotent neuroprotectionDiabetic retinopathyVivo streptozotocinRetinal expressionProtein kinase/extracellular signal-regulated protein kinaseAmino acid peptideKinase/Akt pathwayP-AktP-ERKApoptosis markers
2013
Increased Hippocampal CREB Phosphorylation in Dopamine D3 Receptor Knockout Mice Following Passive Avoidance Conditioning
D’Amico A, Scuderi S, Leggio G, Castorina A, Drago F, D’Agata V. Increased Hippocampal CREB Phosphorylation in Dopamine D3 Receptor Knockout Mice Following Passive Avoidance Conditioning. Neurochemical Research 2013, 38: 2516-2523. PMID: 24100927, DOI: 10.1007/s11064-013-1164-3.Peer-Reviewed Original ResearchConceptsMitogen-activated protein kinaseCAMP response element-binding proteinNuclear transcription factor cAMP response element-binding proteinTranscription factor cAMP response element-binding proteinExtracellular signal-regulated kinase 1/2C-Jun N-terminal kinaseCREB phosphorylationSignal-regulated kinase 1/2Response element-binding proteinElement-binding proteinProtein kinaseDe novo synthesisKinase 1/2ERK signalingAkt activationBinding proteinPhosphorylationPhosphorylation levelsP38 phosphorylationGenetic backgroundKnockout mice displayNovo synthesisKinaseSynaptic functionAktDopamine D3 receptor deletion increases tissue plasminogen activator (tPA) activity in prefrontal cortex and hippocampus
Castorina A, D’Amico A, Scuderi S, Leggio G, Drago F, D’Agata V. Dopamine D3 receptor deletion increases tissue plasminogen activator (tPA) activity in prefrontal cortex and hippocampus. Neuroscience 2013, 250: 546-556. PMID: 23906635, DOI: 10.1016/j.neuroscience.2013.07.053.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlotting, WesternBrain-Derived Neurotrophic FactorCyclic AMP Response Element-Binding ProteinDopamine and cAMP-Regulated Phosphoprotein 32FibrinolysinGlycogen Synthase Kinase 3Glycogen Synthase Kinase 3 betaHippocampusImmunohistochemistryLearningMaleMemoryMiceMice, KnockoutOncogene Protein v-aktPhosphorylationPrefrontal CortexReal-Time Polymerase Chain ReactionReceptors, Dopamine D3RNA, MessengerRNA, Ribosomal, 18STissue Plasminogen Activator