2015
Different Retinal Expression Patterns of IL-1α, IL-1β, and Their Receptors in a Rat Model of Type 1 STZ-Induced Diabetes
Scuderi S, D’amico A, Federico C, Saccone S, Magro G, Bucolo C, Drago F, D’Agata V. Different Retinal Expression Patterns of IL-1α, IL-1β, and Their Receptors in a Rat Model of Type 1 STZ-Induced Diabetes. Journal Of Molecular Neuroscience 2015, 56: 431-439. PMID: 25676032, DOI: 10.1007/s12031-015-0505-x.Peer-Reviewed Original ResearchConceptsIL-1 family membersDiabetic retinopathyIL-1αRetinal layersIL-1raIL-1βIL-1RIInvolvement of inflammationGanglion cell layerNew pharmacological approachesRetinal expression patternType 1 diabetesEffects of hyperglycemiaReceptor IL-1RIFamily membersCommon complicationDiabetic patientsDiabetic ratsProinflammatory cytokinesInflammatory processInterleukin-1βIntraperitoneal injectionRat modelInner plexiformIL-1RII
2012
Ameliorative effect of PACAP and VIP against increased permeability in a model of outer blood retinal barrier dysfunction
Scuderi S, D’Amico A, Castorina A, Imbesi R, Carnazza M, D’Agata V. Ameliorative effect of PACAP and VIP against increased permeability in a model of outer blood retinal barrier dysfunction. Peptides 2012, 39: 119-124. PMID: 23220033, DOI: 10.1016/j.peptides.2012.11.015.Peer-Reviewed Original ResearchMeSH KeywordsBlood-Retinal BarrierCapillary PermeabilityCell LineClaudin-1DextransDiabetes ComplicationsElectric ImpedanceFluorescein-5-isothiocyanateGene ExpressionGlucoseHumansInterleukin-1betaMacular EdemaOccludinPituitary Adenylate Cyclase-Activating PolypeptideRetinal Pigment EpitheliumTight JunctionsVasoactive Intestinal PeptideZonula Occludens-1 ProteinConceptsDiabetic macular edemaBlood-retinal barrierTransepithelial electrical resistanceBRB functionBlood-retinal barrier dysfunctionOuter blood-retinal barrierEffects of PACAPHuman retinal pigment epithelial cellsFITC-dextran diffusionRetinal pigment epithelial cellsZO-1 expressionTight junctionsPigment epithelial cellsMacular edemaMajor complicationsInflammatory aspectsRetinal barrierRetinal injuryBarrier dysfunctionIL-1βDiabetic retinopathyDiabetic milieuTJ-related proteinsOccludin expressionNormal glucose