Epidermal growth factor receptor (EGFR) and neuregulin (Neu) activation in human airway epithelial cells exposed to nickel acetate
Giunta S, Castorina A, Scuderi S, Patti C, D’Agata V. Epidermal growth factor receptor (EGFR) and neuregulin (Neu) activation in human airway epithelial cells exposed to nickel acetate. Toxicology In Vitro 2011, 26: 280-287. PMID: 22210268, DOI: 10.1016/j.tiv.2011.12.012.Peer-Reviewed Original ResearchConceptsEpidermal growth factor receptorPhosphorylated proteinsGrowth factor receptorFactor receptorBcl-2Suppression of apoptosisAirway epithelial cellsEpithelial cellsReduced EGFRBax protein expressionApoptosis initiationEpithelial cell lineBEAS-2B cellsCell deathDNA fragmentationDNA damageAirway epithelial cell lineHuman airway epithelial cellsExpression levelsProteinApoptosisProtein expressionCell linesInitiation of carcinogenesisPotential involvement