2018
Fibroblast growth factor 2 is necessary for the antidepressant effects of fluoxetine
Simard S, Shail P, MacGregor J, Sayed M, Duman RS, Vaccarino FM, Salmaso N. Fibroblast growth factor 2 is necessary for the antidepressant effects of fluoxetine. PLOS ONE 2018, 13: e0204980. PMID: 30273396, PMCID: PMC6166983, DOI: 10.1371/journal.pone.0204980.Peer-Reviewed Original ResearchConceptsChronic variable stressSelective serotonin reuptake inhibitorsPost-mortem brainsGlucocorticoid receptorTherapeutic effectMood disordersAnxiety behaviorFgf2 knockout miceAnti-depressant effectsSerotonin reuptake inhibitorsEffects of fluoxetineTreatment of depressionHippocampal glucocorticoid receptorsAnti-depressant medicationWild-type miceEffect of CVSAnti-depressive agentsNovel therapeutic targetFGF2 geneFibroblast growth factor-2HPA changesAstroglial functionAntidepressant effectsAntidepressant medicationAntidepressant treatment
2017
Loss of TrkB Signaling in Parvalbumin-Expressing Basket Cells Results in Network Activity Disruption and Abnormal Behavior
Xenos D, Kamceva M, Tomasi S, Cardin JA, Schwartz ML, Vaccarino FM. Loss of TrkB Signaling in Parvalbumin-Expressing Basket Cells Results in Network Activity Disruption and Abnormal Behavior. Cerebral Cortex 2017, 28: 3399-3413. PMID: 28968898, PMCID: PMC6132287, DOI: 10.1093/cercor/bhx173.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBehavior, AnimalCerebral CortexElectrophysiological PhenomenaEvoked PotentialsInterneuronsLearning DisabilitiesMembrane GlycoproteinsMemory DisordersMice, Inbred C57BLMice, KnockoutMovement DisordersNeocortexNeuronsParvalbuminsProtein-Tyrosine KinasesPyramidal CellsSurvival AnalysisConceptsBrain-derived neurotrophic factorCKO miceBasket cellsParvalbumin cellsExcitatory neuronsParvalbumin-expressing (PV-expressing) basket cellsPutative excitatory neuronsParvalbumin-Expressing InterneuronsPrincipal excitatory neuronsInhibitory synaptic connectionsCell-intrinsic roleCortical interneuron developmentConditional knockout miceTrkB receptorsMotor deficitsTrkB SignalingPyramidal neuronsGABAergic systemNeurotrophic factorLocal field potentialsProfound hyperactivityCortical volumeNeuronal activityKnockout miceSensory cortex
2016
Fibroblast Growth Factor 2 Modulates Hypothalamic Pituitary Axis Activity and Anxiety Behavior Through Glucocorticoid Receptors
Salmaso N, Stevens HE, McNeill J, ElSayed M, Ren Q, Maragnoli ME, Schwartz ML, Tomasi S, Sapolsky RM, Duman R, Vaccarino FM. Fibroblast Growth Factor 2 Modulates Hypothalamic Pituitary Axis Activity and Anxiety Behavior Through Glucocorticoid Receptors. Biological Psychiatry 2016, 80: 479-489. PMID: 27133954, PMCID: PMC8009045, DOI: 10.1016/j.biopsych.2016.02.026.Peer-Reviewed Original ResearchConceptsFibroblast growth factor-2Hippocampal glucocorticoid receptor expressionGlucocorticoid receptor expressionAdrenal axis activityKO miceAxis activityAnxiety behaviorReceptor expressionHypothalamic-pituitary axis activityReceptor KO miceFGF2 administrationWild-type miceGrowth factor 2Receptor subtypesTherapeutic effectNeuroendocrine studiesAdult miceGlucocorticoid receptorGR promoter regionsFGF2 levelsMeasures of anxietyMiceMotor behaviorFGF2 geneFactor 2
2015
Altered expression of neuropeptides in FoxG1-null heterozygous mutant mice
Frullanti E, Amabile S, Lolli MG, Bartolini A, Livide G, Landucci E, Mari F, Vaccarino FM, Ariani F, Massimino L, Renieri A, Meloni I. Altered expression of neuropeptides in FoxG1-null heterozygous mutant mice. European Journal Of Human Genetics 2015, 24: 252-257. PMID: 25966633, PMCID: PMC4717204, DOI: 10.1038/ejhg.2015.79.Peer-Reviewed Original ResearchConceptsBasal gangliaAdult brainParvalbumin-positive GABAergic interneuronsNeonatal brain developmentWild-type littermatesGroup of neuropeptidesHeterozygous mutant miceHippocampal neurogenesisImpaired social interactionCalcium-dependent signalingTotal brainGABAergic interneuronsNeuronal excitabilityControl of movementHippocampal neuronsArginine vasopressinBehavioral impairmentsWhole brainMammalian forebrainHeterozygous miceMutant miceFOXG1 geneBrain developmentBrainAltered expression
2014
Leptin signaling in astrocytes regulates hypothalamic neuronal circuits and feeding
Kim JG, Suyama S, Koch M, Jin S, Argente-Arizon P, Argente J, Liu ZW, Zimmer MR, Jeong JK, Szigeti-Buck K, Gao Y, Garcia-Caceres C, Yi CX, Salmaso N, Vaccarino FM, Chowen J, Diano S, Dietrich MO, Tschöp MH, Horvath TL. Leptin signaling in astrocytes regulates hypothalamic neuronal circuits and feeding. Nature Neuroscience 2014, 17: 908-910. PMID: 24880214, PMCID: PMC4113214, DOI: 10.1038/nn.3725.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAstrocytesCell CountEatingExcitatory Postsynaptic PotentialsGlial Fibrillary Acidic ProteinHypothalamusImmunohistochemistryIn Situ HybridizationLeptinMaleMelanocortinsMiceMice, KnockoutMicroscopy, ElectronNerve NetNeuronsPrimary Cell CulturePro-OpiomelanocortinPulmonary Gas ExchangeReal-Time Polymerase Chain ReactionRNA, MessengerSignal Transduction
2012
Oligodendrocyte Regeneration after Neonatal Hypoxia Requires FoxO1-Mediated p27Kip1 Expression
Jablonska B, Scafidi J, Aguirre A, Vaccarino F, Nguyen V, Borok E, Horvath TL, Rowitch DH, Gallo V. Oligodendrocyte Regeneration after Neonatal Hypoxia Requires FoxO1-Mediated p27Kip1 Expression. Journal Of Neuroscience 2012, 32: 14775-14793. PMID: 23077062, PMCID: PMC3517297, DOI: 10.1523/jneurosci.2060-12.2012.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornCell DifferentiationCells, CulturedCyclin-Dependent Kinase Inhibitor p27Forkhead Box Protein O1Forkhead Transcription FactorsGene Expression Regulation, DevelopmentalHumansHypoxia, BrainInfantInfant, NewbornMiceMice, 129 StrainMice, Inbred C57BLMice, KnockoutMice, TransgenicNerve RegenerationOligodendrogliaConceptsDiffuse white matter injuryNeonatal hypoxiaOligodendrocyte regenerationOligodendrocyte progenitor cell proliferationWhite matter injuryWhite matter lesionsPermanent neurodevelopmental disabilityCritical developmental time windowWhite matter developmentOverexpression of FoxO1Preterm infantsProgenitor cell proliferationDevelopmental time windowMatter lesionsOligodendrocyte deathAbnormal myelinationNeurodevelopmental disabilitiesMouse modelBiphasic effectP27Kip1 expressionNull miceOligodendrogenesisHypoxiaOligodendrocyte differentiationOligodendrocyte developmentLearning and Memory Depend on Fibroblast Growth Factor Receptor 2 Functioning in Hippocampus
Stevens HE, Jiang GY, Schwartz ML, Vaccarino FM. Learning and Memory Depend on Fibroblast Growth Factor Receptor 2 Functioning in Hippocampus. Biological Psychiatry 2012, 71: 1090-1098. PMID: 22541947, PMCID: PMC3371339, DOI: 10.1016/j.biopsych.2012.03.013.Peer-Reviewed Original ResearchConceptsFGF receptor 2Fibroblast growth factorDentate gyrusReceptor 2Embryonic knockoutWater maze probe trialGrowth factor receptor 2Reference memoryFactor receptor 2Spatial reference memoryNeural stem cellsFibroblast growth factor receptor 2Immature neuronsCortical neuronsHippocampal volumeInducible knockout miceParvalbumin interneuronsShort-term learningGranule cellsKnockout miceSeparate cellular componentsHippocampusLong-term reference memoryAdult spatial memoryGrowth factorImpaired motor coordination and disrupted cerebellar architecture in Fgfr1 and Fgfr2 double knockout mice
Smith K, Williamson TL, Schwartz ML, Vaccarino FM. Impaired motor coordination and disrupted cerebellar architecture in Fgfr1 and Fgfr2 double knockout mice. Brain Research 2012, 1460: 12-24. PMID: 22578469, PMCID: PMC3361544, DOI: 10.1016/j.brainres.2012.04.002.Peer-Reviewed Original ResearchConceptsFibroblast growth factor receptorHuman GFAP promoterInner granule cell layerDKO miceGranule cell numberGranule cell progenitorsRadial glial stem cellsMidline glial structuresImpaired motor coordinationCerebellar sizeGranule cell layerDouble knockout miceGlial precursor cellsGlial stem cellsCell numberGranule neuron precursorsGrowth factor receptorGABA interneuronsGranule cell migrationCerebral cortexExternal granular layerMolecular layerMotor coordinationGranule cellsKnockout mice
2010
Fgfr2 Is Required for the Development of the Medial Prefrontal Cortex and Its Connections with Limbic Circuits
Stevens HE, Smith KM, Maragnoli ME, Fagel D, Borok E, Shanabrough M, Horvath TL, Vaccarino FM. Fgfr2 Is Required for the Development of the Medial Prefrontal Cortex and Its Connections with Limbic Circuits. Journal Of Neuroscience 2010, 30: 5590-5602. PMID: 20410112, PMCID: PMC2868832, DOI: 10.1523/jneurosci.5837-09.2010.Peer-Reviewed Original ResearchConceptsMedial prefrontal cortexCerebral cortexFibroblast growth factor receptorCKO miceExcitatory neuronsPrefrontal cortexCortical neuron developmentEntire cerebral cortexRadial glial cellsSpecific fibroblast growth factor receptorsGrowth factor receptorGABAergic neuronsLimbic circuitsCortical neuronsGlial cellsSubcortical stationsBed nucleusCortical developmentLimbic systemStria terminalisSynaptic terminalsSecondary decreaseNeuronal precursorsVentricular zoneNeuron development
2008
Decrease in excitatory neurons, astrocytes and proliferating progenitors in the cerebral cortex of mice lacking exon 3 from the Fgf2 gene
Chen K, Ohkubo Y, Shin D, Doetschman T, Sanford LP, Li H, Vaccarino FM. Decrease in excitatory neurons, astrocytes and proliferating progenitors in the cerebral cortex of mice lacking exon 3 from the Fgf2 gene. BMC Neuroscience 2008, 9: 94. PMID: 18826624, PMCID: PMC2577114, DOI: 10.1186/1471-2202-9-94.Peer-Reviewed Original Research
2007
Notch regulates cell fate and dendrite morphology of newborn neurons in the postnatal dentate gyrus
Breunig JJ, Silbereis J, Vaccarino FM, Šestan N, Rakic P. Notch regulates cell fate and dendrite morphology of newborn neurons in the postnatal dentate gyrus. Proceedings Of The National Academy Of Sciences Of The United States Of America 2007, 104: 20558-20563. PMID: 18077357, PMCID: PMC2154470, DOI: 10.1073/pnas.0710156104.Peer-Reviewed Original ResearchConceptsAbrogation of NotchCell cycle exitNeuronal fate determinationPrecursor cellsTransit-amplifying cellsFate determinationInducible gainCell fateCycle exitNeural precursor cellsModulates SurvivalMolecular controlPostnatal progenitor cellsLifelong additionHippocampal morphogenesisDifferentiation statePostnatal dentate gyrusNewborn granule cellsMembrane receptorsNeural stemGenetic ablationExpression of Notch1Structural plasticityProgenitor cellsEnvironmental modulatorsDeficiency in Inhibitory Cortical Interneurons Associates with Hyperactivity in Fibroblast Growth Factor Receptor 1 Mutant Mice
Smith K, Fagel DM, Stevens HE, Rabenstein RL, Maragnoli ME, Ohkubo Y, Picciotto MR, Schwartz ML, Vaccarino FM. Deficiency in Inhibitory Cortical Interneurons Associates with Hyperactivity in Fibroblast Growth Factor Receptor 1 Mutant Mice. Biological Psychiatry 2007, 63: 953-962. PMID: 17988653, DOI: 10.1016/j.biopsych.2007.09.020.Peer-Reviewed Original ResearchMeSH KeywordsAmphetamineAnimalsBehavior, AnimalBiogenic MonoaminesCell CountCentral Nervous System StimulantsCerebral CortexDisease Models, AnimalDopamine AgentsExploratory BehaviorFibroblast Growth Factor 1Glutamate DecarboxylaseHyperkinesisLocomotionMaleMethylphenidateMiceMice, KnockoutMotor ActivityNerve Tissue ProteinsNeural InhibitionNeuronsSignal TransductionConceptsInhibitory cortical circuitsCortical pyramidal neuronsD2 receptor antagonistGrowth factor receptor 1Spontaneous locomotor hyperactivityFibroblast growth factor receptor 1Factor receptor 1Inhibitory neuronal subtypesLocomotor hyperactivityDopamine agonistsCerebral cortexPyramidal neuronsBasal gangliaMotor hyperactivityReceptor antagonistInhibitory interneuronsTyrosine hydroxylaseCortical circuitsPsychiatric disordersLocomotor responseNeuronal subtypesReceptor 1Mutant miceDopamine transporterSpatial learning
2006
Midline radial glia translocation and corpus callosum formation require FGF signaling
Smith KM, Ohkubo Y, Maragnoli ME, Rašin M, Schwartz ML, Šestan N, Vaccarino FM. Midline radial glia translocation and corpus callosum formation require FGF signaling. Nature Neuroscience 2006, 9: 787-797. PMID: 16715082, DOI: 10.1038/nn1705.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAstrocytesCell MovementCell ShapeCerebral CortexCorpus CallosumDown-RegulationFemaleFibroblast Growth Factor 8Fibroblast Growth FactorsGrowth ConesMaleMiceMice, KnockoutMice, TransgenicNeurogliaReceptor, Fibroblast Growth Factor, Type 1Receptor, Fibroblast Growth Factor, Type 2RNA InterferenceSignal TransductionConceptsRadial glial cellsGlial cellsSomal translocationRadial gliaCorpus callosum formationReceptor 1 geneCallosal dysgenesisCerebral cortexFibroblast growth factor receptor 1 (FGFR1) geneIndusium griseumDorsomedial cortexDorsolateral cortexKnockout miceCortexAstrogliaApical endfeetFGFR1 geneAstrocytesGliaAxon guidanceDorsal midlinePrecise targetingCellsUnexpected roleFGF
2004
Fibroblast Growth Factor 2 Is Required for Maintaining the Neural Stem Cell Pool in the Mouse Brain Subventricular Zone
Zheng W, Nowakowski RS, Vaccarino FM. Fibroblast Growth Factor 2 Is Required for Maintaining the Neural Stem Cell Pool in the Mouse Brain Subventricular Zone. Developmental Neuroscience 2004, 26: 181-196. PMID: 15711059, DOI: 10.1159/000082136.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiomarkersBrainCell Cycle ProteinsCell DifferentiationCell DivisionCell LineageCell ProliferationCerebral CortexDown-RegulationImmunohistochemistryLateral VentriclesMiceMice, KnockoutNeurogliaNeuronsOlfactory BulbReceptor Protein-Tyrosine KinasesReceptor, Fibroblast Growth Factor, Type 2Receptors, Fibroblast Growth FactorStem CellsConceptsStem cell poolNeural stem cellsFgf2 knockout miceSlower cell cycle kineticsProgenitor cell populationsSubventricular zoneCell poolNeural stem cell poolGene productsProgenitor populationsFibroblast growth factor-2Olfactory bulbKnockout miceCell cycleOlfactory bulb neurogenesisMolecular markersSmaller olfactory bulbsGrowth factor 2Brain subventricular zoneAnterior subventricular zoneReceptor proteinGlial fibrillary acidic proteinCell cycle kineticsStem cellsFibrillary acidic protein
2002
Fibroblast Growth Factor 2 Is Necessary for the Growth of Glutamate Projection Neurons in the Anterior Neocortex
Korada S, Zheng W, Basilico C, Schwartz ML, Vaccarino FM. Fibroblast Growth Factor 2 Is Necessary for the Growth of Glutamate Projection Neurons in the Anterior Neocortex. Journal Of Neuroscience 2002, 22: 863-875. PMID: 11826116, PMCID: PMC6758485, DOI: 10.1523/jneurosci.22-03-00863.2002.Peer-Reviewed Original ResearchConceptsCerebral cortexParietal cortexAnterior cerebral cortexGlutamatergic pyramidal neuronsGABA receptor agonistsGlutamatergic neuronal populationsDuration of sleepAnterior cortical regionsBasic fibroblast growth factorCell numberNull mutant miceGranule cell numberFibroblast growth factor-2Fibroblast growth factorGABA interneuronsGrowth factor 2Fgf2-/- micePyramidal neuronsInhibitory neurotransmissionProjection neuronsAnterior neocortexReceptor agonistPyramidal cellsOccipital cortexNeuronal populations
2000
Basic Fibroblast Growth Factor (Fgf2) Is Necessary for Cell Proliferation and Neurogenesis in the Developing Cerebral Cortex
Raballo R, Rhee J, Lyn-Cook R, Leckman J, Schwartz M, Vaccarino F. Basic Fibroblast Growth Factor (Fgf2) Is Necessary for Cell Proliferation and Neurogenesis in the Developing Cerebral Cortex. Journal Of Neuroscience 2000, 20: 5012-5023. PMID: 10864959, PMCID: PMC6772267, DOI: 10.1523/jneurosci.20-13-05012.2000.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisCell DivisionCerebral CortexChoroid PlexusEmbryonic and Fetal DevelopmentFibroblast Growth Factor 2Gene Expression Regulation, DevelopmentalGerm-Line MutationGestational AgeMiceMice, KnockoutProsencephalonReceptor Protein-Tyrosine KinasesReceptor, Fibroblast Growth Factor, Type 1Receptors, Fibroblast Growth FactorTelencephalonConceptsFgf2 knockout micePseudostratified ventricular epitheliumKnockout miceCerebral cortexCortical neuronsFrontal cerebral cortexDeep cortical layersBasic fibroblast growth factorEnd of neurogenesisCortical neuron numberNeuronal progenitor cellsNull mutant miceBasic fibroblast growth factor (bFGF) geneFibroblast growth factorDegree of apoptosisLarge neuronsBasal gangliaCortical layersFgf2 knockoutGrowth factor geneMutant miceVentricular epitheliumGermline mutationsNeuron numberNeurogenesis
1999
Changes in cerebral cortex size are governed by fibroblast growth factor during embryogenesis
Vaccarino F, Schwartz M, Raballo R, Nilsen J, Rhee J, Zhou M, Doetschman T, Coffin J, Wyland J, Hung Y. Changes in cerebral cortex size are governed by fibroblast growth factor during embryogenesis. Nature Neuroscience 1999, 2: 246-253. PMID: 10195217, DOI: 10.1038/6350.Peer-Reviewed Original ResearchConceptsPseudostratified ventricular epitheliumFibroblast growth factor-2Number of gliaAdult cerebral cortexEnd of neurogenesisCerebral cortex sizeFibroblast growth factorGrowth factor 2Cerebral cortexCerebral ventricleSingle microinjectionCortical neuronsBrdU studiesCortical progenitorsVentricular epitheliumCortex sizeGrowth factorRat embryosFGF2 geneEarly neurogenesisFGF receptorsFactor 2GliaNeurogenesisCell cycle length