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Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma
The Krauthammer Lab has conducted the bioinformatics analysis for a recent Nature Genetics study on the sequencing of nearly 150 melanoma exomes. See the original article here. Highlights of the article include the discovery of a recurrent and activating mutation (P29S) in RAC1, and frequent mutations in PPP6C and other phosphatases. See related press releases: Yale, USNews, Herald Sun, Science Editor Choice.
Source: Nature Genetics