2024
Spatiotemporal Organization of Prefrontal Norepinephrine Influences Neuronal Activity
Glaeser-Khan S, Savalia N, Cressy J, Feng J, Li Y, Kwan A, Kaye A. Spatiotemporal Organization of Prefrontal Norepinephrine Influences Neuronal Activity. ENeuro 2024, 11: eneuro.0252-23.2024. PMID: 38702188, PMCID: PMC11134306, DOI: 10.1523/eneuro.0252-23.2024.Peer-Reviewed Original ResearchTwo-photon imagingLocus coeruleusPrefrontal cortexOptical flow analysisIn vivo two-photon imagingInfluence neuronal activityVesicle exocytosisControl of cortical activityNE releaseGPCR-based sensorsNE dynamicsLocal fieldNeuronal calciumNeuronal firingCell firingNE roleNorepinephrineHomogeneous fieldNeuronal activitySpatiotemporal activity patternsNeurotransmitter functionSensorLight-sheet imagingAxonal dynamicsSpatial scalesFrontal Norepinephrine Represents a Threat Prediction Error Under Uncertainty
Basu A, Yang J, Yu A, Glaeser-Khan S, Rondeau J, Feng J, Krystal J, Li Y, Kaye A. Frontal Norepinephrine Represents a Threat Prediction Error Under Uncertainty. Biological Psychiatry 2024, 96: 256-267. PMID: 38316333, PMCID: PMC11269024, DOI: 10.1016/j.biopsych.2024.01.025.Peer-Reviewed Original ResearchPrediction error signalsResponses to conditioned stimuliThreat prediction errorsReinforcement learning modelThreat learningAnticipation of dangerAversive learningMemory strengthConditioned stimulusNoradrenergic signalingDefensive behaviorError signalPrediction errorAuditory stimuliTask structureNorepinephrine releaseNorepinephrineLearning modelsPredictive signalsStimuliFootshockDopamineLearningRewardErrorPsilocybin and other Psychedelics
Kaye A, Kelmendi B, Rivera M, Pittenger C. Psilocybin and other Psychedelics. 2024 DOI: 10.1016/b978-0-323-95702-1.00178-0.Peer-Reviewed Original ResearchPsychedelic drugsSerotonin 5-HT2A receptorsHuman neuroimaging studiesAlcohol use disorderPatterns of activityTransdiagnostic efficacyDepressive disorderPsychedelic agentsClassic psychedelicsNeuroimaging studiesMode networkUse disorderPsychedelic propertiesPsychotherapeutic supportAssociation cortexPsilocybinPsychological effectsPsychedelicsDifferential effectsHealing contextControlled Substances ActDisordersPotential therapeutic useControlled studiesSerotonin
2023
Circuit- and Behavioral- Level Investigation of Plasticity After Administration of Entactogens in Mice
Kaye A, Kwan A, Pittenger C, Yu A, Yang J. Circuit- and Behavioral- Level Investigation of Plasticity After Administration of Entactogens in Mice. Biological Psychiatry 2023, 93: s57. DOI: 10.1016/j.biopsych.2023.02.156.Peer-Reviewed Original Research