2003
Lack of effect of a single dose of hydrocortisone on serotonin1A receptors in recovered depressed patients measured by positron emission tomography with [11C]WAY-100635
Bhagwagar Z, Montgomery A, Grasby P, Cowen P. Lack of effect of a single dose of hydrocortisone on serotonin1A receptors in recovered depressed patients measured by positron emission tomography with [11C]WAY-100635. Biological Psychiatry 2003, 54: 890-895. PMID: 14573316, DOI: 10.1016/s0006-3223(03)00466-9.Peer-Reviewed Original ResearchConceptsReceptor BPMajor depressionPositron emission tomographySerotonin-1A receptor bindingEmission tomographyPositron emission tomography scanAcute major depressionEmission tomography scanCertain brain areasElevated cortisol levelsLack of effectCortisol hypersecretionAcute administrationSingle doseHydrocortisone treatmentDepressed patientsTomography scanHealthy volunteersBrain areasCrossover designCortisol levelsSerotonin1A receptorsMale subjectsFemale subjectsPatients
2001
PET measurement of the influence of corticosteroids on serotonin-1A receptor number
Montgomery A, Bench C, Young A, Hammers A, Gunn R, Bhagwagar Z, Grasby P. PET measurement of the influence of corticosteroids on serotonin-1A receptor number. Biological Psychiatry 2001, 50: 668-676. PMID: 11704073, DOI: 10.1016/s0006-3223(01)01205-7.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnti-Inflammatory AgentsBinding, CompetitiveDose-Response Relationship, DrugDouble-Blind MethodDrug Administration ScheduleFemaleHippocampusHumansHydrocortisoneHypothalamo-Hypophyseal SystemMaleMiddle AgedPituitary-Adrenal SystemReceptors, SerotoninReceptors, Serotonin, 5-HT1Tomography, Emission-ComputedConceptsPositron emission tomographyReceptor numberReceptor bindingPlacebo-controlled designInfluence of corticosteroidsSingle doseSerotonergic systemPreclinical studiesCorticosteroidsNormal subjectsModulatory effectsAlters 5Corticosteroid levelsBrain regionsEmission tomographyElevated levelsPET measurementsHippocampusHuman brainPatientsHydrocortisoneDoseBrainReceptors