2004
Increased Brain GABA Concentrations Following Acute Administration of a Selective Serotonin Reuptake Inhibitor
Bhagwagar Z, Wylezinska M, Taylor M, Jezzard P, Matthews P, Cowen P. Increased Brain GABA Concentrations Following Acute Administration of a Selective Serotonin Reuptake Inhibitor. American Journal Of Psychiatry 2004, 161: 368-370. PMID: 14754790, DOI: 10.1176/appi.ajp.161.2.368.Peer-Reviewed Original ResearchConceptsGamma-aminobutyric acidBrain GABA concentrationsAcute administrationGABA concentrationSelective serotonin reuptake inhibitor citalopramSelective serotonin reuptake inhibitorsSerotonin reuptake inhibitor citalopramCortical gamma-aminobutyric acidActions of SSRIsGABA/creatine ratiosReuptake inhibitor citalopramSerotonin reuptake inhibitorsGABA neuronsSSRI treatmentReuptake inhibitorsIntravenous citalopramDepressed patientsCreatine ratioHealthy volunteersCortical levelOccipital cortexCrossover designMean increaseMagnetic resonance spectroscopyMood improvementNormalization of Enhanced Fear Recognition by Acute SSRI Treatment in Subjects With a Previous History of Depression
Bhagwagar Z, Cowen P, Goodwin G, Harmer C. Normalization of Enhanced Fear Recognition by Acute SSRI Treatment in Subjects With a Previous History of Depression. American Journal Of Psychiatry 2004, 161: 166-168. PMID: 14702268, DOI: 10.1176/appi.ajp.161.1.166.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAdultCitalopramDepressive Disorder, MajorDiagnostic and Statistical Manual of Mental DisordersDouble-Blind MethodFacial ExpressionFearFemaleHumansMiddle AgedRecognition, PsychologySelective Serotonin Reuptake Inhibitors
2003
Contrasting effects of citalopram and reboxetine on waking salivary cortisol
Harmer C, Bhagwagar Z, Shelley N, Cowen P. Contrasting effects of citalopram and reboxetine on waking salivary cortisol. Psychopharmacology 2003, 167: 112-114. PMID: 12605289, DOI: 10.1007/s00213-003-1417-y.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic Uptake InhibitorsAdultCircadian RhythmCitalopramFemaleHumansHydrocortisoneHypothalamo-Hypophyseal SystemMaleMorpholinesPituitary-Adrenal SystemReboxetineSalivaSelective Serotonin Reuptake InhibitorsWakefulnessConceptsHPA axis activitySalivary cortisolAxis activitySelective noradrenaline re-uptake inhibitorNoradrenaline re-uptake inhibitorSelective serotonin re-uptake inhibitor citalopramConclusionsShort-term treatmentDifferent antidepressant medicationsHPA axis functionEffect of citalopramRe-uptake inhibitorsDouble-blind designShort-term treatmentBasal salivary cortisol levelsDiurnal salivary cortisolSalivary free cortisolSalivary cortisol levelsAntidepressant administrationRationaleAcute administrationReboxetine treatmentAntidepressant medicationAntidepressant treatmentAxis functionHPA axisAdrenal axisAcute SSRI Administration Affects the Processing of Social Cues in Healthy Volunteers
Harmer C, Bhagwagar Z, Perrett D, Völlm B, Cowen P, Goodwin G. Acute SSRI Administration Affects the Processing of Social Cues in Healthy Volunteers. Neuropsychopharmacology 2003, 28: 148-152. PMID: 12496951, DOI: 10.1038/sj.npp.1300004.Peer-Reviewed Original ResearchMeSH KeywordsAdultAffectAnxietyCitalopramCuesDouble-Blind MethodEmotionsFacial ExpressionFemaleHumansMiddle AgedSelective Serotonin Reuptake InhibitorsSocial PerceptionConceptsEmotional processingFacial expressionsFacial expression recognition taskExpression recognition taskAcute SSRI administrationBasic emotionsSocial cuesEmotional intensityNeural processesSocial informationRecognition taskEarly acute effectsReduced response timeEmotional standardsSubjective experienceSocial behaviorTesting sessionsSSRI administrationAcute administrationMoodSelective serotonin reuptake inhibitorsProcessingSerotonin reuptake inhibitorsRole of serotoninHealthy female volunteers
2002
Acute administration of citalopram facilitates memory consolidation in healthy volunteers
Harmer C, Bhagwagar Z, Cowen P, Goodwin G. Acute administration of citalopram facilitates memory consolidation in healthy volunteers. Psychopharmacology 2002, 163: 106-110. PMID: 12185407, DOI: 10.1007/s00213-002-1151-x.Peer-Reviewed Original ResearchMeSH KeywordsAdultAttentionCitalopramCognitionDouble-Blind MethodFemaleHumansMemoryMemory, Short-TermMental RecallMiddle AgedSelective Serotonin Reuptake InhibitorsVerbal LearningConceptsMemory consolidationCognitive actionsLong-term memory performanceAuditory Verbal Learning TestRecall/recognitionVerbal Learning TestVerbal memory testsSustained attention performanceFacilitate memory consolidationAttention performanceMemory testImmediate recallLearning TestMemory performanceCognitive functionMemory deficitsInformation processingGroups of subjectsSerotonergic neurotransmissionGroup designRecallNon-specific increaseSuccessful pharmacological treatmentDepressed patientsSymptom improvementAcute citalopram administration produces correlated increases in plasma and salivary cortisol
Bhagwagar Z, Hafizi S, Cowen P. Acute citalopram administration produces correlated increases in plasma and salivary cortisol. Psychopharmacology 2002, 163: 118-120. PMID: 12185409, DOI: 10.1007/s00213-002-1149-4.Peer-Reviewed Original ResearchMeSH KeywordsAdultArea Under CurveCitalopramCross-Over StudiesDose-Response Relationship, DrugDouble-Blind MethodFemaleHumansHydrocortisoneMaleMiddle AgedSalivaSelective Serotonin Reuptake InhibitorsConceptsSalivary cortisol levelsCortisol levelsSelective serotonin re-uptake inhibitorsSalivary cortisolSerotonin re-uptake inhibitorsAcute citalopram administrationRe-uptake inhibitorsCross-over designSalivary cortisol concentrationsCitalopram administrationIntravenous administrationCortisol releaseHealthy volunteersCortisol concentrationsSaliva cortisolCitalopramCortisolParallel increaseAdministrationCorrelated increaseAcceptable meansState and trait abnormalities in serotonin function in major depression
Bhagwagar Z, Whale R, Cowen P. State and trait abnormalities in serotonin function in major depression. The British Journal Of Psychiatry 2002, 180: 24-28. PMID: 11772847, DOI: 10.1192/bjp.180.1.24.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAdultAnalysis of VarianceAntidepressive Agents, Second-GenerationCitalopramDepressive DisorderDouble-Blind MethodFemaleHumansHydrocortisoneMaleMiddle AgedProlactinSelective Serotonin Reuptake InhibitorsSerotoninConceptsCortisol responseHealthy controlsMajor depressionSerotonin functionRecovered subjectsAdrenal axis dysfunctionBrain serotonin functionPlacebo-controlled designMarker of vulnerabilityAxis dysfunctionClinical recoveryReuptake inhibitorsUnmedicated subjectsProlactin responseDepressed patientsEndocrine responsesNeuroendocrine studiesDepressed subjectsCitalopramDepressionPatientsSubjectsResponseDysfunctionNeurotransmission
2001
Pindolol Augmentation of Selective Serotonin Reuptake Inhibitors: PET Evidence That the Dose Used in Clinical Trials Is Too Low
Rabiner E, Bhagwagar Z, Gunn R, Sargent P, Bench C, Cowen P, Grasby P. Pindolol Augmentation of Selective Serotonin Reuptake Inhibitors: PET Evidence That the Dose Used in Clinical Trials Is Too Low. American Journal Of Psychiatry 2001, 158: 2080-2082. PMID: 11729033, DOI: 10.1176/appi.ajp.158.12.2080.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrainDepressive Disorder, MajorDose-Response Relationship, DrugDrug Administration ScheduleDrug Therapy, CombinationFemaleHumansMaleMiddle AgedPindololReceptors, SerotoninReceptors, Serotonin, 5-HT1Selective Serotonin Reuptake InhibitorsTomography, Emission-ComputedTreatment OutcomeConceptsPositron emission tomographyDose of pindololClinical trialsDepressed patientsSelective serotonin reuptake inhibitorsSignificant occupancyPresent clinical trialSerotonin reuptake inhibitorsPindolol augmentationAntidepressant medicationReuptake inhibitorsPET evidenceEmission tomographyPindololTrialsDoseAutoreceptorsMedicationsPatientsInconsistent resultsEfficacyVast majorityDosesDecreased sensitivity of 5-HT1D receptors in melancholic depression
Whale R, Clifford E, Bhagwagar Z, Cowen P. Decreased sensitivity of 5-HT1D receptors in melancholic depression. The British Journal Of Psychiatry 2001, 178: 454-457. PMID: 11331562, DOI: 10.1192/bjp.178.5.454.Peer-Reviewed Original ResearchMeSH KeywordsAdultDepressive DisorderFemaleHuman Growth HormoneHumansHydrocortisoneMaleMiddle AgedOxazolidinonesReceptors, SerotoninSelective Serotonin Reuptake InhibitorsSerotonin Receptor AgonistsTryptaminesConceptsSelective serotonin reuptake inhibitorsGrowth hormone responseGrowth hormone releaseSSRI treatmentMajor depressionHormone releaseMelancholic depressionHormone responseBrain serotonin functionSerotonin reuptake inhibitorsReuptake inhibitorsDepressive syndromeReceptor agonistReceptor subtypesSerotonin functionHealthy subjectsReceptor sensitivityPatientsControl groupMarked reductionZolmitriptanDepressionReceptorsTreatmentSelective ligands