2004
Effects of beta-adrenoceptor blockade on components of human decision-making
Rogers R, Lancaster M, Wakeley J, Bhagwagar Z. Effects of beta-adrenoceptor blockade on components of human decision-making. Psychopharmacology 2004, 172: 157-164. PMID: 14716472, DOI: 10.1007/s00213-003-1641-5.Peer-Reviewed Original ResearchConceptsProbabilistic rewardsCortico-limbic systemsBrain imaging studiesSeries of choicesOrbitofrontal cortexEmotional aspectsSubjective stateSubjects designPunishment signalsCingulate cortexNegative ratingsProbability of losingNeurological patientsSubjective changesHealthy volunteersMoodRewardBeta-adrenoceptor blockadeCatecholamine systemsBeta-adrenoceptor blockersVisual analog scaleImaging studiesSlower heart rateCortexConclusionsThese results
2002
Tryptophan Depletion Alters the Decision-Making of Healthy Volunteers through Altered Processing of Reward Cues
Rogers R, Tunbridge E, Bhagwagar Z, Drevets W, Sahakian B, Carter C. Tryptophan Depletion Alters the Decision-Making of Healthy Volunteers through Altered Processing of Reward Cues. Neuropsychopharmacology 2002, 28: 153-162. PMID: 12496952, DOI: 10.1038/sj.npp.1300001.Peer-Reviewed Original ResearchConceptsAmino acid drinkReward cuesOrbitofrontal cortexNegative outcomesReduced discriminationAltered processingTryptophan depletionHuman choiceCuesMonoamine neurotransmitter systemsAltered discriminationNeurotransmitter systemsBiasesDiscriminationCortexGamblesProcessingPsychiatric illnessCognitionHealthy volunteersAnhedoniaMoodFunctioningPresent studyLittle evidence