2021
Lung Cancer Driven by BRAFG469V Mutation Is Targetable by EGFR Kinase Inhibitors
Huo K, Notsuda H, Fang Z, Liu N, Gebregiworgis T, Li Q, Pham N, Li M, Liu N, Shepherd F, Marshall C, Ikura M, Moghal N, Tsao M. Lung Cancer Driven by BRAFG469V Mutation Is Targetable by EGFR Kinase Inhibitors. Journal Of Thoracic Oncology 2021, 17: 277-288. PMID: 34648945, DOI: 10.1016/j.jtho.2021.09.008.Peer-Reviewed Original ResearchConceptsEGFR tyrosine kinase inhibitorsTyrosine kinase inhibitorsLung cancerBRAF mutationsNon-small cell lung cancerNon-V600 BRAF mutationsPatient-derived xenograft modelsKinase inhibitorsCell lung cancerEGFR-TKI gefitinibSingle-agent vemurafenibV600E BRAF mutationRNA knockdownCell linesExpression of BRAFOff-target inhibitionCombination dabrafenibTKI gefitinibTargeted therapyLung adenocarcinomaXenograft modelEGFR kinase inhibitorsPatientsOncogenic driversBRAF
2013
Inhibition of Signal Transducer and Activator of Transcription 3 and Cyclooxygenase-2 Is Involved in Radiosensitization of Cepharanthine in HeLa Cells
Fang Z, Li Y, Chen Z, Wang J, Zhu L. Inhibition of Signal Transducer and Activator of Transcription 3 and Cyclooxygenase-2 Is Involved in Radiosensitization of Cepharanthine in HeLa Cells. International Journal Of Gynecological Cancer 2013, 23: 608. PMID: 23466568, DOI: 10.1097/igc.0b013e31828a05fd.Peer-Reviewed Original ResearchConceptsHeLa cellsSignal transducerTranscription 3C-MycSTAT3 target genesCell cycle regulators c-MycBcl-2Antiapoptotic Bcl-2Target genesWestern blot analysisHeLa cell lineApoptosis inductionBlot analysisNude mouse xenograftsCell linesReduced expressionSTAT3Apoptosis analysisMouse xenograftsSignificant radiosensitizationIR treatmentClonogenic assayActivatorCellsCytotoxic effects