2024
Cotranslational molecular condensation of cochaperones and assembly factors facilitates axonemal dynein biogenesis
Li Y, Xu W, Cheng Y, Djenoune L, Zhuang C, Cox A, Britto C, Yuan S, Wang S, Sun Z. Cotranslational molecular condensation of cochaperones and assembly factors facilitates axonemal dynein biogenesis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2402818121. PMID: 39541357, PMCID: PMC11588059, DOI: 10.1073/pnas.2402818121.Peer-Reviewed Original ResearchConceptsDynein axonemal assembly factorsAssembly factorsCytosolic fociOuter dynein armsMacromolecular machinesAxonemal dyneinsAssembly hubDynein armsMolecular condensateLiquid-liquid phase separationCochaperoneEncoding mRNAFoci formationCiliary motilityStable interactionLRRC6Functional significanceRUVBL1DyneinMRNAAssembly of multiple componentsAssemblyPotential mechanismsRUVBL2Biogenesis
2015
Intraciliary Calcium Oscillations Initiate Vertebrate Left-Right Asymmetry
Yuan S, Zhao L, Brueckner M, Sun Z. Intraciliary Calcium Oscillations Initiate Vertebrate Left-Right Asymmetry. Current Biology 2015, 25: 556-567. PMID: 25660539, PMCID: PMC4469357, DOI: 10.1016/j.cub.2014.12.051.Peer-Reviewed Original ResearchConceptsLeft-right organizerLR developmentCiliary motilityVertebrate left–right asymmetryLeft-right signalingLive zebrafish embryosVertebrate developmentLeft-right asymmetryZebrafish embryosSensory ciliaPolycystin-2Signaling cascadesMolecular signalsMolecular mechanismsIntraciliary calciumCation channelsMotilityBilateral symmetryCalcium sinkCiliaCalcium oscillationsPKD2SignalingEmbryosExtracellular fluid
2013
Chapter Nine Dissecting the Functional Interplay Between the TOR Pathway and the Cilium in Zebrafish
Yuan S, Zhao L, Sun Z. Chapter Nine Dissecting the Functional Interplay Between the TOR Pathway and the Cilium in Zebrafish. Methods In Enzymology 2013, 525: 159-189. PMID: 23522470, DOI: 10.1016/b978-0-12-397944-5.00009-2.Peer-Reviewed Original ResearchConceptsTOR pathwayCilia length controlGreen alga ChlamydomonasKupffer's vesiclePatterning defectsCiliary precursorsNutrient cuesCiliopathic phenotypesVertebrate modelTranslational regulationAlga ChlamydomonasCilia morphologyFunctional interplayEmbryonic organsFluid flow generationZebrafishCellular growthCilia lengthMajor regulatorChlamydomonasRapamycin (mTOR) pathwayLength controlCiliary motilityFundamental processesMechanistic relationship