2024
Bayesian pathway analysis over brain network mediators for survival data
Tian X, Li F, Shen L, Esserman D, Zhao Y. Bayesian pathway analysis over brain network mediators for survival data. Biometrics 2024, 80: ujae132. PMID: 39530270, PMCID: PMC11555425, DOI: 10.1093/biomtc/ujae132.Peer-Reviewed Original ResearchMeSH KeywordsAlzheimer DiseaseBayes TheoremBrainComputer SimulationHumansModels, StatisticalNerve NetNeuroimagingSurvival AnalysisConceptsAccelerated failure time modelFailure time modelBrain connectivityAlzheimer's Disease Neuroimaging Initiative studyMaximum information extractionResponse regressionBayesian approachInformation extractionTime modelSurvival dataNoisy componentsUnique edgeWhite matter fiber tractsNetwork configurationBrain networksInterconnection networksNetworkNetwork mediatorsBrain
2022
Simulating time-to-event data subject to competing risks and clustering: A review and synthesis
Meng C, Esserman D, Li F, Zhao Y, Blaha O, Lu W, Wang Y, Peduzzi P, Greene E. Simulating time-to-event data subject to competing risks and clustering: A review and synthesis. Statistical Methods In Medical Research 2022, 32: 305-333. PMID: 36412111, DOI: 10.1177/09622802221136067.Peer-Reviewed Original Research
2021
Bayesian network-driven clustering analysis with feature selection for high-dimensional multi-modal molecular data
Zhao Y, Chang C, Hannum M, Lee J, Shen R. Bayesian network-driven clustering analysis with feature selection for high-dimensional multi-modal molecular data. Scientific Reports 2021, 11: 5146. PMID: 33664338, PMCID: PMC7933297, DOI: 10.1038/s41598-021-84514-0.Peer-Reviewed Original ResearchMeSH KeywordsBayes TheoremCarcinogenesisCluster AnalysisComputational BiologyEpigenomicsGenomicsHumansModels, StatisticalNeoplasmsTranscriptomeConceptsMolecular dataJoint posterior distributionHigh-dimensional settingsVariational Bayes approachSingle-cell dataArt clustering methodsPosterior distributionMolecular profiling dataComputational efficiencyCanonical oncogenicTranscriptomic alterationsBiological discoveryModel inferenceBayes approachCell decompositionStemness phenotypeProfiling dataSingle cellsComputational methodsBulk tumorPathway alterationsNebulaClustering methodAnalysis settingsCell data
2018
Regional vulnerability in Alzheimer's disease: The role of cell‐autonomous and transneuronal processes
Acosta D, Powell F, Zhao Y, Raj A. Regional vulnerability in Alzheimer's disease: The role of cell‐autonomous and transneuronal processes. Alzheimer's & Dementia 2018, 14: 797-810. PMID: 29306583, PMCID: PMC5994366, DOI: 10.1016/j.jalz.2017.11.014.Peer-Reviewed Original Research