2024
Collaborative Survival Analysis on Predicting Alzheimer’s Disease Progression
Xu W, Wang S, Shen L, Zhao Y. Collaborative Survival Analysis on Predicting Alzheimer’s Disease Progression. Statistics In Biosciences 2024, 1-24. DOI: 10.1007/s12561-024-09459-0.Peer-Reviewed Original ResearchAlzheimer's diseaseGenes associated with neuronal developmentAlzheimer's Disease Neuroimaging InitiativeGenetic dataAlzheimer's disease progressionGenetic variationPhenotypic varianceAD progressionGenetic featuresNeuronal developmentGenetic biomarkersAlzheimerADNI databaseMild cognitive impairmentSNPsCanonical correlation analysisGenesStructural MRI scansCombination of brain imagingBrain imagingGeneticsProgression of mild cognitive impairmentAD literatureTime-to-event outcomesTime-to-event predictionsBayesian mixed model inference for genetic association under related samples with brain network phenotype
Tian X, Wang Y, Wang S, Zhao Y, Zhao Y. Bayesian mixed model inference for genetic association under related samples with brain network phenotype. Biostatistics 2024, 25: 1195-1209. PMID: 38494649, DOI: 10.1093/biostatistics/kxae008.Peer-Reviewed Original ResearchSample relatednessGenetic studiesGenetic association studiesRisk genetic variantsImaging genetics studiesPopulation structureAssociation studiesQuantitative phenotypesQuantitative geneticsGenetic basisGenetic variantsGenetic associationGenetic contributionPhenotypeRelatednessConnectivity traitsNetwork phenotypesConnectivity phenotypesMarkov chain Monte CarloMixed-effects modelsPedigreeGeneticsBiological structuresTraitsHuman Connectome Project
2020
Bayesian sparse heritability analysis with high-dimensional neuroimaging phenotypes
Zhao Y, Li T, Zhu H. Bayesian sparse heritability analysis with high-dimensional neuroimaging phenotypes. Biostatistics 2020, 23: 467-484. PMID: 32948880, PMCID: PMC9308456, DOI: 10.1093/biostatistics/kxaa035.Peer-Reviewed Original ResearchConceptsHeritability analysisHuman complex traitsLarge-scale phenotypeQuantitative geneticsComplex traitsPhenotypic variationTrait selectionGenetic datasetsSingle phenotypeDownstream analysisGenetic contributionHeritability estimationPhenotypeTraitsCentral roleNeuroimaging phenotypesUnited Kingdom BiobankHierarchical selectionPhenotypic methodsGeneticsHeritabilitySelectionVariationBrain variation