2023
Longitudinal simultaneous fMRI and mesoscale calcium imaging in a mouse model of Alzheimer’s disease
Mandino F, Shen X, Desrosiers-Gregoire G, O'Connor D, Mukherjee B, DeLuca K, Hamodi A, Owens A, Ha Y, Qu A, Onofrey J, Papademetris X, Chakravarty M, Crair M, Strittmatter S, Lake E. Longitudinal simultaneous fMRI and mesoscale calcium imaging in a mouse model of Alzheimer’s disease. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2023 DOI: 10.58530/2023/3914.Peer-Reviewed Original ResearchMouse model of Alzheimer's diseaseModel of Alzheimer's diseaseMesoscale calcium imagingAlzheimer's diseaseBehavioral deficitsExcitatory neural activityMultimodal neuroimagingBOLD signalSimultaneous fMRINeuroimaging changesNeural activityBOLD fMRIPreliminary evidenceCalcium imagingClinically accessible biomarkersMesoscopic calcium imagingSpontaneous activityFMRINeuroimagingBOLDDeficitsComplex relationship
2021
Sex differences in connectivity in the default mode network in healthy aging adults
Ficek B, Horien C, Lacadie C, Shen X, Scheinost D, Constable T, Fredericks C. Sex differences in connectivity in the default mode network in healthy aging adults. Alzheimer's & Dementia 2021, 17 DOI: 10.1002/alz.056050.Peer-Reviewed Original ResearchIntrinsic connectivity distributionDefault mode networkAlzheimer's diseaseHealthy aging adultsElevated riskAging AdultsLarge cross-sectional studyPosterior default mode networkSex differencesMode networkCross-sectional cohortCross-sectional studyPreclinical Alzheimer's diseaseSymptomatic Alzheimer's diseaseResting-state scansSex-based differencesAnterior nodeAD showDMN connectivityHealthy adultsFunctional MRI dataNormal individualsResults FemalesZ-scoreFunctional connectivity