2010
Common Genes Contribute to Depressive Symptoms and Heart Rate Variability: The Twins Heart Study
Su S, Lampert R, Lee F, Bremner JD, Snieder H, Jones L, Murrah NV, Goldberg J, Vaccarino V. Common Genes Contribute to Depressive Symptoms and Heart Rate Variability: The Twins Heart Study. Twin Research And Human Genetics 2010, 13: 1-9. PMID: 20158303, PMCID: PMC2905576, DOI: 10.1375/twin.13.1.1.Peer-Reviewed Original ResearchConceptsHeart rate variabilityCoronary artery diseaseDepressive symptomsHRV indicesReduced heart rate variabilityRate variabilityElectrocardiographic Holter recordingsMeasurements of HRVBeck Depression Inventory-IICurrent depressive symptomsSignificant inverse correlationVietnam Era Twin RegistryFrequency domain variablesBivariate genetic modelingCommon neurobiological dysfunctionArtery diseaseAutonomic dysregulationHolter recordingsHeart StudyMiddle-aged male twinsHRV frequencySymptomsCommon genetic componentInventory-IIHigh frequency
2009
A Twin Study of Metabolic Syndrome and Autonomic Tone
GEHI AK, LAMPERT R, VELEDAR E, LEE F, GOLDBERG J, JONES L, MURRAH N, ASHRAF A, VACCARINO V. A Twin Study of Metabolic Syndrome and Autonomic Tone. Journal Of Cardiovascular Electrophysiology 2009, 20: 422-428. PMID: 19054251, PMCID: PMC2722434, DOI: 10.1111/j.1540-8167.2008.01363.x.Peer-Reviewed Original ResearchConceptsLower heart rate variabilityHeart rate variabilityAutonomic toneMetS componentsMetabolic syndromeMetS risk factorsHigher cardiovascular mortalityCoronary heart diseaseOne-unit incrementTwin pairsCardiovascular mortalityCardiac deathOverall mortalityAtrial fibrillationPotential confoundersHeart diseaseRisk factorsHeart StudyMiddle-aged male twinsAbnormal modulationRate variabilityMale twinsMetS.MetSSyndrome