2009
Pleiotropy of C-Reactive Protein Gene Polymorphisms With C-Reactive Protein Levels and Heart Rate Variability in Healthy Male Twins
Su S, Lampert R, Zhao J, Bremner JD, Miller A, Snieder H, Lee F, Khan D, Goldberg J, Vaccarino V. Pleiotropy of C-Reactive Protein Gene Polymorphisms With C-Reactive Protein Levels and Heart Rate Variability in Healthy Male Twins. The American Journal Of Cardiology 2009, 104: 1748-1754. PMID: 19962488, PMCID: PMC2818743, DOI: 10.1016/j.amjcard.2009.07.063.Peer-Reviewed Original ResearchConceptsC-reactive protein levelsHeart rate variabilityCRP gene polymorphismsCoronary artery diseaseCRP levelsGene polymorphismsArtery diseaseHRV indicesSymptomatic coronary artery diseaseReduced heart rate variabilityRate variabilityLower heart rate variabilityC-Reactive Protein Gene PolymorphismsPlasma CRP levelsCRP plasma levelsCRP single-nucleotide polymorphismsMale twinsProtein levelsSingle nucleotide polymorphismsHealthy male twinsBivariate structural equation modelingHigh-frequency powerCRP geneFrequency domain measuresProtein gene polymorphismsA Twin Study of Metabolic Syndrome and Autonomic Tone
GEHI AK, LAMPERT R, VELEDAR E, LEE F, GOLDBERG J, JONES L, MURRAH N, ASHRAF A, VACCARINO V. A Twin Study of Metabolic Syndrome and Autonomic Tone. Journal Of Cardiovascular Electrophysiology 2009, 20: 422-428. PMID: 19054251, PMCID: PMC2722434, DOI: 10.1111/j.1540-8167.2008.01363.x.Peer-Reviewed Original ResearchConceptsLower heart rate variabilityHeart rate variabilityAutonomic toneMetS componentsMetabolic syndromeMetS risk factorsHigher cardiovascular mortalityCoronary heart diseaseOne-unit incrementTwin pairsCardiovascular mortalityCardiac deathOverall mortalityAtrial fibrillationPotential confoundersHeart diseaseRisk factorsHeart StudyMiddle-aged male twinsAbnormal modulationRate variabilityMale twinsMetS.MetSSyndrome
2008
Depressive Symptoms and Heart Rate Variability: Evidence for a Shared Genetic Substrate in a Study of Twins
Vaccarino V, Lampert R, Bremner JD, Lee F, Su S, Maisano C, Murrah NV, Jones L, Jawed F, Afzal N, Ashraf A, Goldberg J. Depressive Symptoms and Heart Rate Variability: Evidence for a Shared Genetic Substrate in a Study of Twins. Psychosomatic Medicine 2008, 70: 628-636. PMID: 18606724, PMCID: PMC5884077, DOI: 10.1097/psy.0b013e31817bcc9e.Peer-Reviewed Original Research