2010
Common Genes Contribute to Depressive Symptoms and Heart Rate Variability: The Twins Heart Study
Su S, Lampert R, Lee F, Bremner JD, Snieder H, Jones L, Murrah NV, Goldberg J, Vaccarino V. Common Genes Contribute to Depressive Symptoms and Heart Rate Variability: The Twins Heart Study. Twin Research And Human Genetics 2010, 13: 1-9. PMID: 20158303, PMCID: PMC2905576, DOI: 10.1375/twin.13.1.1.Peer-Reviewed Original ResearchConceptsHeart rate variabilityCoronary artery diseaseDepressive symptomsHRV indicesReduced heart rate variabilityRate variabilityElectrocardiographic Holter recordingsMeasurements of HRVBeck Depression Inventory-IICurrent depressive symptomsSignificant inverse correlationVietnam Era Twin RegistryFrequency domain variablesBivariate genetic modelingCommon neurobiological dysfunctionArtery diseaseAutonomic dysregulationHolter recordingsHeart StudyMiddle-aged male twinsHRV frequencySymptomsCommon genetic componentInventory-IIHigh frequency
2009
Pleiotropy of C-Reactive Protein Gene Polymorphisms With C-Reactive Protein Levels and Heart Rate Variability in Healthy Male Twins
Su S, Lampert R, Zhao J, Bremner JD, Miller A, Snieder H, Lee F, Khan D, Goldberg J, Vaccarino V. Pleiotropy of C-Reactive Protein Gene Polymorphisms With C-Reactive Protein Levels and Heart Rate Variability in Healthy Male Twins. The American Journal Of Cardiology 2009, 104: 1748-1754. PMID: 19962488, PMCID: PMC2818743, DOI: 10.1016/j.amjcard.2009.07.063.Peer-Reviewed Original ResearchConceptsC-reactive protein levelsHeart rate variabilityCRP gene polymorphismsCoronary artery diseaseCRP levelsGene polymorphismsArtery diseaseHRV indicesSymptomatic coronary artery diseaseReduced heart rate variabilityRate variabilityLower heart rate variabilityC-Reactive Protein Gene PolymorphismsPlasma CRP levelsCRP plasma levelsCRP single-nucleotide polymorphismsMale twinsProtein levelsSingle nucleotide polymorphismsHealthy male twinsBivariate structural equation modelingHigh-frequency powerCRP geneFrequency domain measuresProtein gene polymorphisms
2008
Decreased heart rate variability is associated with higher levels of inflammation in middle-aged men
Lampert R, Bremner JD, Su S, Miller A, Lee F, Cheema F, Goldberg J, Vaccarino V. Decreased heart rate variability is associated with higher levels of inflammation in middle-aged men. American Heart Journal 2008, 156: 759.e1-759.e7. PMID: 18926158, PMCID: PMC2587932, DOI: 10.1016/j.ahj.2008.07.009.Peer-Reviewed Original ResearchConceptsC-reactive proteinCoronary artery diseaseBody mass indexHeart rate variabilityTraditional risk factorsInterleukin-6Risk factorsAutonomic functionPhysical activityDevelopment of CADSymptomatic coronary artery diseaseTraditional CAD risk factorsHigh-density lipoprotein cholesterolRate variabilityGraded inverse relationshipCAD risk factorsMiddle-aged menHigh-density lipoproteinAmbulatory electrocardiogram monitoringHigh-frequency powerAutonomic dysfunctionLipoprotein cholesterolArtery diseaseMass indexAutonomic dysregulation
2004
1072-215 Depressive symptoms are associated with reduced heart rate variability in individuals without coronary artery disease
Vaccarino V, Lampert R, Lee F, Bremner J, Abramson J, Murrah N, Afzal N, Cheema F, Goldberg J. 1072-215 Depressive symptoms are associated with reduced heart rate variability in individuals without coronary artery disease. Journal Of The American College Of Cardiology 2004, 43: a120-a121. DOI: 10.1016/s0735-1097(04)90504-9.Peer-Reviewed Original Research
2001
Day-to-day reproducibility of mental stress-induced abnormal left ventricular function response in patients with coronary artery disease and its relationship to autonomic activation
Jain D, Joska T, Lee F, Burg M, Lampert R, Zaret B. Day-to-day reproducibility of mental stress-induced abnormal left ventricular function response in patients with coronary artery disease and its relationship to autonomic activation. Journal Of Nuclear Cardiology 2001, 8: 347-355. PMID: 11391305, DOI: 10.1067/mnc.2001.113517.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseSystolic blood pressureLV ejection fractionLV dysfunctionRate-pressure productBlood pressureAnger recallMS taskHeart rate variabilityAutonomic activationLVEF responseArtery diseaseMental stressSympathetic activationHeart rateSymptomatic coronary artery diseaseRate variabilityAbnormal LVEF responseVentricular function responseChronic stable anginaExercise-induced ischemiaLeft ventricular dysfunctionAdverse prognostic signLF/HFCardiac medications
1994
Circadian variation of sustained ventricular tachycardia in patients with coronary artery disease and implantable cardioverter-defibrillators.
Lampert R, Rosenfeld L, Batsford W, Lee F, McPherson C. Circadian variation of sustained ventricular tachycardia in patients with coronary artery disease and implantable cardioverter-defibrillators. Circulation 1994, 90: 241-247. PMID: 8026004, DOI: 10.1161/01.cir.90.1.241.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseSustained ventricular tachycardiaVentricular tachycardiaArtery diseaseCircadian variationVT occurrenceSudden deathMechanism of VTLife-threatening ventricular tachycardiaEpisodes of VTAmbulatory ECG monitoringConsecutive patientsEjection fractionDrug therapyIndividual patientsEpidemiological dataPatientsTachycardiaECG monitoringCircadian patternDiseaseArrhythmiasDeathInfrequent eventEpisodes