2014
Dynamin 2 regulation of integrin endocytosis, but not VEGF signaling, is crucial for developmental angiogenesis
Lee M, Skoura A, Park E, Landskroner-Eiger S, Jozsef L, Luciano A, Murata T, Pasula S, Dong Y, Bouaouina M, Calderwood D, Ferguson S, De Camilli P, Sessa W. Dynamin 2 regulation of integrin endocytosis, but not VEGF signaling, is crucial for developmental angiogenesis. Journal Of Cell Science 2014, 127: e1-e1. DOI: 10.1242/jcs.153080.Peer-Reviewed Original Research
2001
Distinction between signaling mechanisms in lipid rafts vs. caveolae
Sowa G, Pypaert M, Sessa W. Distinction between signaling mechanisms in lipid rafts vs. caveolae. Proceedings Of The National Academy Of Sciences Of The United States Of America 2001, 98: 14072-14077. PMID: 11707586, PMCID: PMC61169, DOI: 10.1073/pnas.241409998.Peer-Reviewed Original ResearchConceptsCav-1Raft domainsLipid raftsCholesterol-rich lipid raft domainsLipid raft domainsCaveolae assemblyEndothelial nitric oxide synthaseCaveolae biogenesisAcylated proteinsSignal transductionSpatial regulationPlasma membraneNegative regulationCaveolin-1CaveolaeFirst clear exampleRaftsPhysical interactionProteinCellsRegulationENOS functionBiogenesisDomainClear example
1999
Regulation of endothelium-derived nitric oxide production by the protein kinase Akt
Fulton D, Gratton J, McCabe T, Fontana J, Fujio Y, Walsh K, Franke T, Papapetropoulos A, Sessa W. Regulation of endothelium-derived nitric oxide production by the protein kinase Akt. Nature 1999, 399: 597-601. PMID: 10376602, PMCID: PMC3637917, DOI: 10.1038/21218.Peer-Reviewed Original ResearchConceptsProtein kinase AktKinase AktSerine/threonine protein kinase AktMutant eNOSRole of phosphorylationEndothelial nitric oxide synthaseSerine 1179Akt substrateSignal transductionGene transferAktAdenovirus-mediated gene transferPhosphorylationGrowth factorVascular endothelial growth factorEndothelial cellsRegulationSynthase isoformsEndothelial growth factorNitric oxide productionTransductionVascular remodellingOxide productionIsoformsProduction
1997
Regulation of the NOS Gene Family
Papapetropoulos A, Sessa W. Regulation of the NOS Gene Family. 1997, 66-85. DOI: 10.1007/978-1-4615-6039-5_4.Peer-Reviewed Original ResearchMammalian cell biologyBasic cellular processesFive-electron oxidationNOS gene familyNitric oxide synthase (NOS) familyMammalian genomesSynthase familyGene familyCellular processesMolecular regulationDistinct genesCell biologyLower speciesRecent discoveryGenesNOS isoformsIsoformsRegulationNitric oxideComplex functionsGenomeRecent advancesExcellent reviewsFamilyBiology